巻号一覧
41 巻, 9 号
選択された号の論文の20件中1～20を表示しています
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TOSHIHIRO SHIBATA, OSAMU NAKAYAMA, MASAKUNI OKUHARA, YASUHISA TSURUMI, ...1988 年 41 巻 9 号 p. 1163-1169
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーFR-900490 is a new type of immunoactive substance produced by a fungus Discosia sp. F-11809.
The colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sarcoma 180 tumor bearing mouse, was restored to normal level by the addition of FR-900490 in vitro. Furthermore, in mitomycin C (MMC)-treated mice the subsequent administration of FR-900490 caused a significant increase of cfu-c in bone marrow cells depressed by MMC.抄録全体を表示PDF形式でダウンロード (642K) -
TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATIONSTEPHEN H. LARSEN, LA VERNE D. BOECK, FREDERICK P. MERTZ, JONATHAN W. ...1988 年 41 巻 9 号 p. 1170-1177
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリー16-Deethylindanomycin (A83094A) is a novel pyrrole-ether antibiotic produced by a strain of Streptomyces setonii. The antibiotic, which is structurally similar to indanomycin (X-14547A), is active in vitro against Gram-positive bacteria as well as coccidia.抄録全体を表示PDF形式でダウンロード (651K) -
I. ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIESRALPH GROTE, AXEL ZEECK, HANNELORE DRAUTZ, HANS ZÄHNER1988 年 41 巻 9 号 p. 1178-1185
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーThe yellow colabomycins A to C, three new antibiotics of the manumycin group produced by Streptomyces griseoflavus (strain Tü 2880), were detected by chemical screening. They were isolated from mycelium extracts by column chromatography on various adsorbents, followed by preparative reversed phase HPLC. The main compound, colabomycin A (1), was characterized and shown to be chiefly biologically active against Gram-positive bacteria and stem cells of murine L1210 leukemia.抄録全体を表示PDF形式でダウンロード (468K) -
II. STRUCTURE OF COLABOMYCIN ARALPH GROTE, AXEL ZEECK, JOHN M. BEALE1988 年 41 巻 9 号 p. 1186-1195
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーThe structure of colabomycin A (1) was elucidated by a detailed spectroscopic analysis. Two-dimensional NMR spectroscopy experiments provided assignments of the proton and carbon resonances of the tetraene carboxamide chains occurring in 1. The configurations of eight out of nine double bonds were determined by analysis of their coupling constants. The absolute configurations of C-4 (4S), C-5 (5R) and C-6 (6S) were established from the CD spectra of the parent compound and of 2-(6-oxo-2, 4-hexadienoylamino)-5, 6-epoxy-1, 4-benzoquinone (2), which was obtained from 1 by mild chromic acid oxidation.抄録全体を表示PDF形式でダウンロード (516K) -
SATORU KONDO, KAZUHISA YASUI, MASAHIRO NATSUME, MASATO KATAYAMA, SHING ...1988 年 41 巻 9 号 p. 1196-1204
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPamamycin-607, which showed aerial mycelium-inducing activity, has been isolated from Streptomyces alboniger IFO 12738. At 0.1 μg/disc it induces aerial mycelia in the aerial mycelium-negative strain of S. alboniger but inhibits growth of the substrate mycelia at 10 μg/disc. It also acts as an antibiotic against some fungi and bacteria. When KMnO4 was partitioned with pamamycin-607 between benzene and water, MnO4- but no K+ was transferred from the water to the benzene layer; pamamycin-607 was thus shown to be a novel anion-transfer antibiotic.抄録全体を表示PDF形式でダウンロード (610K) -
I. TAXONOMY OF THE PRODUCING CULTURE, FERMENTATION AND BIOLOGICAL ACTIVITYJ. P. KARWOWSKI, M. JACKSON, R. J. THERIAULT, J. F. PROKOP, M. L. MAUS ...1988 年 41 巻 9 号 p. 1205-1211
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーThe arizonins, a novel complex of antibiotics related to kalafungin, were discovered in the fermentation broth of Actinoplanes sp. AB660D-122. Comparative taxonomic studies indicated that the culture is a new species and therefore has been designated Actinoplanes arizonaensis sp. nov. Two members of the complex, arizonins A1 and B1, exhibit moderate to potent in vitro antimicrobial activity against pathogenic strains of Gram-positive bacteria.抄録全体を表示PDF形式でダウンロード (702K) -
A. D. ARGOUDELIS, L. BACZYNSKYJ, S. A. MIZSAK, F. B. SHILLIDAY, P. F. ...1988 年 41 巻 9 号 p. 1212-1222
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーSenfolomycins A and B (Antimicrob. Agents Chemother. -1965: 828-831, 1966) are two antibacterial agents with physico-chemical and biological properties similar to those of paulomycin. Recent studies indicate that senfolomycin A (C29H36N2O16S, MW 700) has molecular composition and fast atom bombardment MS fragmentation pattern identical to those of paulomycin E. Extensive NMR work indicates that the two antibiotics, which have been separated by HPLC and TLC, differ only in the stereochemistry of the OCH3 group present in their respective sugar moieties. Indirect evident suggests that senfolomycin B is dihydrosenfolomycin A (C29H38N2O16S, MW 702) and in this respect it is related to paulomycin F. The proposed structures for senfolomycins A and B are discussed.抄録全体を表示PDF形式でダウンロード (480K) -
SHINJI FUNAYAMA, YUMI ANRAKU, AKIRA MITA, Zm-Bo YANG, KIYOSHI SHIBATA, ...1988 年 41 巻 9 号 p. 1223-1230
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーVarious derivatives of trienomycin A (1) were prepared and tested for cytocidal activities. All the derivatives except for 22-O-methyltrienomycin A (5) showed reduced cytotoxicity compared with 1. It is concluded that the existence of a triene moiety, free 13-OH and an acyl group at C-11 owe important role for cytocidal activity.抄録全体を表示PDF形式でダウンロード (457K) -
BARRIE W. BYCROFT, CHRISTOPHER MASLEN, STEPHEN J. Box, ALLAN BROWN, JO ...1988 年 41 巻 9 号 p. 1231-1242
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーTwo new β-lactams have been isolated from strains of Serratia and Erwinia sp. and identified as (3R, 5R)- and (3S, 5R)-carbapenam-S-carboxylic acid. These novel carbapenams lack antibacterial activity, are resistant to both β-lactamases I and II from Bacillus cereus and are not detected by the lactamase induction assay. Radiolabelled and stable isotope experiments have established that both metabolites together with the antibiotic 5R-carbapenem-3-carboxylic acid are glutamate and acetate derived. A number of possible pathways for the biosynthesis of these compounds as well as their relationship to the more complex members of the carbapenem family of β-lactam antibiotics are discussed.抄録全体を表示PDF形式でダウンロード (625K) -
ENRICO SELVA, BETH P. GOLDSTEIN, PIETRO FERRARI, ROSA PALLANZA, ERNEST ...1988 年 41 巻 9 号 p. 1243-1252
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーA40926 antibiotics are new glycopeptides which are much more active than other members of this class against Neisseria gonorrhoeae. Their activity against Gram-positive bacteria, including coagulase-negative Staphylococci, is similar to that of other glycopeptides. An A40926 preparation containing factors A and B ("A40926 A+B complex") was hydrolyzed to the aglycone and to the mannosyl and N-acylaminoglucuronyl aglycones. The mannosyl aglycone and the aglycone were less active than A40926 A+B complex against Streptococci and Gram-positive anaerobes and lost the anti-gonorrheal activity. In contrast, the N-acylaminoglucuronyl aglycones were as active as the parent complex against these Gram-positive bacteria and were moderately active against N. gonorrhoeae. The aglycone and, even more so, the N-acylaminoglucuronyl aglycones, had better activity than the parent complex against coagulase-negative Staphylococci. In experimental septicemia in the mouse, A40926 A+B complex and its derivatives had activity proportional to their MIC for the test organism.抄録全体を表示PDF形式でダウンロード (594K) -
KYUICHI NEMOTO, MICHIKO HAYASHI, YUMI SUGAWARA, JUNPEI ITO, FUMINORI A ...1988 年 41 巻 9 号 p. 1253-1259
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーAn assessment of the prophylactic and ameliorative effects of deoxyspergualin (NKT-01), an immunosuppressive agent, was carried out in male MRL/MpJ-1pr/1pr (MRL/1) mice which spontaneously develop lupus-like lesions. When NKT-01 was administered ip daily from the age of either 8 or 19 weeks, diseases such as massive lymphadenopathy, circulating anti-DNA antibody and lupus nephritis were markedly suppressed. The primary response to lipopolysaccharide was significantly reduced in MRL/1 mice administered NKT-01 but the response to sheep red blood cells was not affected. The ability of spleen cells to release interleukins 2 and 3 with or without mitogen was significantly enhanced in mice receiving NKT-01. These findings demonstrate that NKT-01 has therapeutic activity against the development of spontaneous disease in MRL/1 mice.抄録全体を表示PDF形式でダウンロード (421K) -
YASUHIRO SHIGIHARA, YUMI KOIZUMI, TSUYOSHI TAMAMURA, YOSHIKO HOMMA, KU ...1988 年 41 巻 9 号 p. 1260-1264
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (220K) -
SADAO SATO, YOJI FURUKAWA1988 年 41 巻 9 号 p. 1265-1267
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (174K) -
P. R. DAS, B. N. PRAMANIK, V. M. GIRIJAVALLABHAN, A. K. GANGULY1988 年 41 巻 9 号 p. 1268-1271
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (198K) -
KIYOTO EDO, YURIKO AKIYAMA-MURAI, KUNIHITO SAITO, MICHINAO MIZUGAKI, Y ...1988 年 41 巻 9 号 p. 1272-1274
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (250K) -
RALPH GROTE, AXEL ZEECK, HANNELORE DRAUTZ, HANS ZÄHNER1988 年 41 巻 9 号 p. 1275-1276
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (148K) -
TAKESHI YAMADA1988 年 41 巻 9 号 p. 1277-1280
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (285K) -
JIRO ITOH, HIRO-OMI WATABE, SHIGETAKA ISHII, SHUICHI GOMI, MIEKO NAGAS ...1988 年 41 巻 9 号 p. 1281-1284
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (262K) -
MICHIO ICHIMURA, KENICHI MUROI, Kozo ASANO, ISAO KAWAMOTO, FUSAO TOMIT ...1988 年 41 巻 9 号 p. 1285-1288
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (173K) -
J. ZIELINSKI, J. GOLIK, J. PAWLAK, E. BOROWSKI, L. FALKOWSKI1988 年 41 巻 9 号 p. 1289-1291
発行日: 1988/09/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (182K)
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