巻号一覧
43 巻, 8 号
選択された号の論文の26件中1～26を表示しています
- |<
- <
- 1
- >
- >|
-
I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERIZATIONJOSEPH O'SULLIVAN, JOHN MCCULLOUGH, JANICE H. JOHNSON, DANIEL P. BONNE ...1990 年 43 巻 8 号 p. 913-919
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーJanthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Janthinocins A and B were also found to be effective in a Staphylococcus aureus systemic infection in mice.抄録全体を表示PDF形式でダウンロード (326K) -
II. STRUCTURE ELUCIDATIONJANICE H. JOHNSON, ADRIENNE A. TYMIAK, MARK S. BOLGAR1990 年 43 巻 8 号 p. 920-930
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーThe structures of janthinocins A, B and C, three novel macrocyclic peptide lactone antibiotics isolated from fermentations of Janthinobacterium lividum, were determined. The janthinocins are of particular interest because they contain three amino acid residues that have not previously been reported in natural products: Each contains erythro-β-hydroxy-D-leucine while janthinocins A and B also contain β-hydroxytryptophan and β-ketotryptophan, respectively.抄録全体を表示PDF形式でダウンロード (620K) -
MM 47761 AND MM 49721, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF AMYCOLATOPSIS ORIENTALISISOLATION, PURIFICATION AND STRUCTURE DETERMINATIONSTEPHEN J. Box, ANNA L. ELSON, MARTIN L. GILPIN, DAVID J. WINSTANLEY1990 年 43 巻 8 号 p. 931-937
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーTwo glycopeptide antibiotics MM 47761 and MM 49721 have been isolated from Amycolatopsis orientalis NCIB 12608. Fermentation conditions for their production, and methods for their isolation are described. The metabolites have been characterised by physico-chemical and biological properties and the structure determined by a combination of chemical degradation, COSY and NOE NMR studies. Both metabolites showed good antibacterial activity against Gram-positive organisms.抄録全体を表示PDF形式でダウンロード (351K) -
I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIESKOHTAROU FUNAISHI, KENJI KAWAMURA, FUMIO SATOH, MUNEYO HIRAMATSU, MASA ...1990 年 43 巻 8 号 p. 938-947
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーAntibiotics 6108 A1, B, C and D, a new series of analogues of rosaramicin, were found together with rosaramicin, juvenimicin A4 and M-4365 A1 from the cultured broth of strain BA06108 which was assigned to be a new species of Micromonospora. 6108 A1 and C showed inhibitory activity against Gram-positive and some Gram-negative bacteria as potent as rosaramicin and exhibited low acute toxicity in mice. However, 6108 B showed less potent antimicrobial activity and 6108 D showed higher toxicity than those two antibiotics.抄録全体を表示PDF形式でダウンロード (619K) -
I. PRODUCTION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIESAKIRA ITOH, JUNKO IDO, YUKIMASA IWAMOTO, EIICHI GOSHIMA, TOYOHIKO MIKI ...1990 年 43 巻 8 号 p. 948-955
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーA new polyene macrolide antibiotic, YS-822A was isolated from the culture filtrate of a mutant strain H-8 of Streptoverticillium eurocidicum var. asterocidicus S-822. Whereas the original S-822 strain produced not only YS-822 substances but also teleocidin as by-product which is well-known as a strong carcinogenic promotor, the mutagenized H-8 strain produced the antibiotic with only a trace amount of teleocidin. Chemical and biological characterizations of the antibiotic revealed that YS-822A (molecular formula: C37H59NO14) is a new polyene macrolide with a wide antifungal spectrum and a low acute toxicity.抄録全体を表示PDF形式でダウンロード (370K) -
I. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL ACTIVITYKIN SING LAM, GRACE A. HESLER, JACQUELINE M. MATTEI, STEPHEN W. MAMBER ...1990 年 43 巻 8 号 p. 956-960
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーStrain C39108-P210-51 (ATCC 53653), an actinomycete isolated from a soil sample collected in India, was found to produce a new antitumor antibiotic, designated himastatin. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Streptomyces hygroscopicus C39108-P210-51. Himastatin shows antimicrobial activity against Gram-positive bacteria but it is inactive against Gram-negative bacteria. Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells.抄録全体を表示PDF形式でダウンロード (280K) -
II. ISOLATION AND CHARACTERIZATIONJOHN E. LEET, DANIEL R. SCHROEDER, BALA S. KRISHNAN, JAMES A. MATSON1990 年 43 巻 8 号 p. 961-966
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーThe novel antitumor antibiotic himastatin was isolated from cultured broth of Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and crystallization. Degradation and spectroscopic studies have shown that himastatin contains valine, leucine, threonine, α-hydroxyisovaleric acid, 5-hydroxypiperazic acid and a dimeric hexahydropyrroloindole system.抄録全体を表示PDF形式でダウンロード (238K) -
MASAHISA OKA, HIDEO KAMEI, YASUTARO HAMAGISHI, KOJI TOMITA, TAKEO MIYA ...1990 年 43 巻 8 号 p. 967-976
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーA novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A1, A2, B1, B2, C1 and C2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.抄録全体を表示PDF形式でダウンロード (566K) -
OSAMU HARA, C. RICHARD HUTCHINSON1990 年 43 巻 8 号 p. 977-991
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーDNA containing genes for midecamycin(Mdm)-resistance was cloned from Streptomyces mycarofaciens ATCC 21454 (mdmA gene), Streptomyces lividans 66 (Irm gene) and Streptomyces coelicolor A3(2). The phenotype imparted to S. lividans and Streptomyces griseofuscus transformants by the cloned DNA segments indicates that they encode an MLS-type of resistance activity. The mdmA and Irm genes could be distinguished by the phenotype they conferred in S. lividans and S. griseofuscus, whereas the S. lividans Irm and S. coelicolor MLS genes appear to be identical on the basis of their restriction maps and behavior in S. lividans and S. griseofuscus. The DNA sequence of a 1.4-kb BamH I DNA fragment containing the mdmA gene indicates the presence of one complete orf whose deduced product exhibits a high similarity to the deduced product of the Streptomyces thermotolerans carB gene and several other bacterial MLS-resistance genes.抄録全体を表示PDF形式でダウンロード (878K) -
STEVEN L. GOLDBERG, JORGE G. ROMERO, YASHWANT M. DEO1990 年 43 巻 8 号 p. 992-999
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーWe cloned DNA fragments of sisomicin-producing Micromonospora inyoensis1) into Streptomyces plasmid vectors and identified Streptomyces lividans TK24 transformants expressing the M. inyoensis sisomicin-resistance (sisA) gene. The sisA gene was compared to the previously reported Micromonospora purpurea Kan-Gen (kanamycin-gentamicin)-resistance gene2). While the restriction endonuclease digestion patterns of the two determinants appear to be divergent, the genes are nonetheless closely related, based on similar patterns and levels of aminoglycoside-resistance and their ability to cross-hybridize under stringent conditions. We have transformed recombinant plasmid pMD5-2, which carries the sisA gene, into our M. purpurea gentamicin-production strain and determined that gentamicin biosynthesis was not improved.抄録全体を表示PDF形式でダウンロード (612K) -
KAZURO SHIOMI, HIRONOBU IINUMA, HIROSHI NAGANAWA, MASA HAMADA, SEIKO H ...1990 年 43 巻 8 号 p. 1000-1005
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (302K) -
II. STRUCTURE DETERMINATIONSHIGERU NAKAJIMA, KATSUHISA KOJIRI, HAJIME MORISHIMA, MASANORI OKANISH ...1990 年 43 巻 8 号 p. 1006-1009
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (193K) -
XXXXIII OUDEMANSIN X, A NEW ANTIFUNGAL E-β-METHOXYACRYLATE FROM OUDEMANSIELLA RADICATA (RELHAN EX FR.) SINGTIMM ANKE, ANDREAS WERLE, MONIKA BROSS, WOLFGANG STEGLICH1990 年 43 巻 8 号 p. 1010-1011
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (166K) -
III. ISOLATION AND CHARACTERIZATION OF ENACTIN CONGENERSKATSUMI YAMAMOTO, YOSHIKAZU SHIINOKI, MAKI NISHIO, YASUCHIKA MATSUDA, ...1990 年 43 巻 8 号 p. 1012-1017
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (336K) -
HIDEO KAMEI, MASAHISA OKA, YASUTARO HAMAGISHI, KOJI TOMITA, MASATAKA K ...1990 年 43 巻 8 号 p. 1018-1020
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (175K) -
YOSHIO INOUYE, KEIKO OOGOSE, SHOSHIRO NAKAMURA1990 年 43 巻 8 号 p. 1021-1027
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (341K) -
MASATOSHI KAKUSHIMA, MAKI NISHIO, KEI-ICHI NUMATA, MASATAKA KONISHI, T ...1990 年 43 巻 8 号 p. 1028-1030
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (206K) -
NOBUFUSA SERIZAWA, KAORI NAKAHARA, TATSUJI MATSUOKA1990 年 43 巻 8 号 p. 1031-1033
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (214K) -
SATOSHI OMURA, YOSHITAKE TANAKA, ISAO KANAYA, MAYUMI SHINOSE, YOKO TAK ...1990 年 43 巻 8 号 p. 1034-1036
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (221K) -
MICHIO ICHIMURA, TATSUHIRO OGAWA, KEI-ICHI TAKAHASHI, EIJI KOBAYASHI, ...1990 年 43 巻 8 号 p. 1037-1038
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (147K) -
NAOKI ASANO, YUKIHIKO KAMEDA, KATSUHIKO MATSUI, SATOSHI HORII, HIROSHI ...1990 年 43 巻 8 号 p. 1039-1041
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (159K) -
DAVID F. CORBETT, COLIN H. FRYDRYCH, ROBERT SOUTHGATE, MICHAEL J. BASK ...1990 年 43 巻 8 号 p. 1042-1044
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (165K) -
SHIN-ICHI ITO, GUSTAV GILLJAMS, BRITTA WAHREN, HANS WIGZELL, NAOKI YAM ...1990 年 43 巻 8 号 p. 1045-1046
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (120K) -
KENJI SAKAGAMI, KUNIO ATSUMI, ATSUSHI TAMURA, TAKASHI YOSHIDA, KEN NIS ...1990 年 43 巻 8 号 p. 1047-1050
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (208K) -
UWE GOTTSCHALK, AXEL MAIBÜCHER, HENNING MENKE, WOLFGANG KÖHN ...1990 年 43 巻 8 号 p. 1051-1054
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (251K) -
JACK E. BALDWIN, JULIETTE W. BIRD, ROBERT A. FIELD, NIAMH M. O'CALLAGH ...1990 年 43 巻 8 号 p. 1055-1057
発行日: 1990/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (188K)
- |<
- <
- 1
- >
- >|