巻号一覧
44 巻, 8 号
選択された号の論文の17件中1～17を表示しています
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ISOLATION, PURIFICATION AND STRUCTURE DETERMINATIONSTEPHEN J. BOX, NIGEL J. COATES, CHRIS J. DAVIS, MARTIN L. GILPIN, CAT ...1991 年 44 巻 8 号 p. 807-813
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーTwo novel glycopeptide antibiotics MM 55266 and MM 55268 containing fatty acid acyl functions, and of molecular formula C86H89N8O35Cl5 and C87H91N8O35C15, respectively, have been isolated and identified from a complex produced by Amycolatopsis sp. NCIB 40089. Fermentation conditions for their production, and methods for their isolation are described. Structures have been deduced by use of COSY and NOE NMR techniques and supported by chemical degradation studies. Both glycopeptides possessed good antibacterial activity against Gram-positive organisms.抄録全体を表示PDF形式でダウンロード (371K) -
I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICSKANKI KOMIYAMA, SHINJI FUNAYAMA, YUMI ANRAKU, MASAMI ISHIBASHI, YOKO T ...1991 年 44 巻 8 号 p. 814-818
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーA new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0μg/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1, 000μg/ml.抄録全体を表示PDF形式でダウンロード (276K) -
II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATIONSHINJI FUNAYAMA, MASAMI ISHIBASHI, KANKI KOMIYAMA, SATOSHI OMURA1991 年 44 巻 8 号 p. 819-823
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーThe structure of a new cytocidal antibiotic, okicenone was elucidated to be 3, 4-dihydro-4, 6, 9-trihydroxy-8-methyl-1(2H)-anthracenone on the basis of spectroscopic methods.抄録全体を表示PDF形式でダウンロード (182K) -
TAXONOMY, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITYMINORU HANADA, KEIKO KANETA, YUJI NISHIYAMA, YUTAKA HOSHINO, MASATAKA ...1991 年 44 巻 8 号 p. 824-831
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーA new antitumor antibiotic hydramycin was isolated from the fermentation broth of Streptomyces violaceus P950-4 (ATCC 53807). It showed potent antibacterial and cytotoxic activity and increased the survival time of mice inoculated with P388 leukemia. A new structure related to the pluramycin group antibiotics was assigned by its spectroscopic experiments.抄録全体を表示PDF形式でダウンロード (448K) -
I. DISCOVERY, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURAL ELUCIDATIONYUMIKO ITOH, HIROSHI SHIMURA, MAYUMI ITO, NAOHARU WATANABE, MICHIO YAM ...1991 年 44 巻 8 号 p. 832-837
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーA new subspecies of Streptomyces rishiriensis A-5969 (PERM BP-1394) was isolated and shown to produce a novel α, β-unsaturated γ-lactone derivative, MH-031, which exhibited hepatoprotective activity in primary cultured rat hepatocytes intoxicated with D-galactosamine.抄録全体を表示PDF形式でダウンロード (396K) -
RAY S. DEWEY, OTTO D. HENSENS, ALAN W. DOUGLAS, GEORG ALBERS-SCHÖ ...1991 年 44 巻 8 号 p. 838-843
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーThe antibiotic heneicomycin (1), C44H62N2O11, was isolated from cultures of Streptomyces filipinensis as an amorphous yellow powder. Mass spectral and NMR analysis showed the compound to be a deoxy modification of aurodox (2), a member of the elfamycin antibiotic family. A marked change in mass spectral fragmentation compared to aurodox and 1H NMR couplings indicated the absence of the hydroxyl at position 30 of aurodox (position 3 of the tetrahydropyran).抄録全体を表示PDF形式でダウンロード (341K) -
BERNARD PIROTTE, JACQUES DELARGE, JACQUES COYETTE, JEAN-MARIE FRERE1991 年 44 巻 8 号 p. 844-853
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーNewly synthesized 5-acylaminothiazolium salts and one 5-acylaminothiazolidine, considering their chemical structure and reactivity, have been proposed as potential inhibitors of bacterial serine DD-peptidases. A moderate antibiotic activity with (5-phenylacetylamino-3-thiazolio)acetate and (5-phenylacetylaminothiazolidin-3-yl)acetic acid was observed on Staphylococcus aureus ATCC 25923. The methyl- and tert-butyl esters of the thiazolium salt have shown lower MIC values. Moreover, when introduced into an exponential growth phase culture of S. aureus, the three active thiazolium salts induced a partial lysis indicating an impairing of the bacterial cell wall biosynthesis. The observed time-dependent binding of the best compound to the PBPs of S. aureus was too slow and occurred at too high concentrations to account for its MIC value. Consequently, the antibiotic activity of the thiazolium salts on the S. aureus cells seems not to be satisfactorily explained by a penicillin-like interaction with the PBPs.抄録全体を表示PDF形式でダウンロード (646K) -
I. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 3-THIAZOLIOMETHYL DERIVATIVESEIJI NAKAYAMA, KOICHI FUJIMOTO, SHIGEKI MURAMATSU, MASAO MIYAUCHI, KAT ...1991 年 44 巻 8 号 p. 854-863
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーThe synthesis and the structure-activity relationships of 3-thiazoliomethyl cephalosporins are described. In a series of these parenteral compounds, 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido group was found to be a favorable substituent for the C-7 position of the cephem nucleus. They showed potent antibacterial activity against both Gram-positive and Gram-negative bacteria including some β-lactamase producing species.抄録全体を表示PDF形式でダウンロード (482K) -
II. SYNTHESIS AND BIOLOGICAL PROPERTIES OF CS-461 AND RELATED COMPOUNDSEIJI NAKAYAMA, KATSUHIKO WATANABE, MASAO MIYAUCHI, KOICHI FUJIMOTO, SH ...1991 年 44 巻 8 号 p. 864-869
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーThe synthesis, structure-activity relationships, and biological properties of 3-thiazoliomethyl cephalosporins are described. 7-[2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[5-(2-hydroxyethyl)-4-methylthiazoliomethyl]-3-cephem-4-carboxylate sulfate (CS-461) showed potent antibacterial activity against a wide variety of bacteria both in vitro and in vivo. Furthermore, CS-461 exhibited significantly low acute toxicity in mice.抄録全体を表示PDF形式でダウンロード (301K) -
YUHPYNG L. CHEN, KIRK HEDBERG, KAREN GUARINO, JAMES A. RETSEMA, MARGAR ...1991 年 44 巻 8 号 p. 870-884
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリー(6R, 8S)-(2-Benzimidazolyl)hydroxymethylpenicillanic acids (1a-1x) are potent antibacterial agents and β-lactamase inhibitors against Gram-positive bacteria and Haemophilus influenzae. The corresponding (6R, 8R)-isomers (2a-2x), the 6, 6-spiro benzimidazole-penam alcohol (3), (7R, 9S)-(2-benzimidazolyl)hydroxymethylcephalosporanic acid (4), and 6β-(2-benzimidazolyl)aminopenicillanic acid (5) are much less active as antibacterials or β-lactamase inhibitors. The syntheses and structure-activity relationships of these compounds are discussed. Antibacterial activity and β-lactamase inhibition data are presented.抄録全体を表示PDF形式でダウンロード (850K) -
M. B. COX, P. ARJUNAN, S. K. ARORA1991 年 44 巻 8 号 p. 885-894
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーMonocovalent groove binding complexes of antitumor antibiotic naphthyridinomycin and its analogs with DNA sequence d(ATGCAT)2 have been studied by molecular mechanics to understand which enantiomer of the drug and what chirality at C(7) of the drug are preferred for forming better drug-DNA adducts. The effect of hydroquinone intermediate and the substitution at C(11) on drug-DNA interactions have also been investigated. The results indicate that the enantiomer that forms the best adduct is different from the one reported earlier in the literature. The drug with an R configuration at C(7) is preferred for binding. The hydroquinone models do not necessarily provide a given analog of the drug with additional favorable DNA interactions. The substitution at-C(11) by OH provides the best binding model. This finding agrees well with the results from previous biochemical studies. The sequence specific studies indicate that the sequence d(ATGCAT)2 is slightly preferred over others.抄録全体を表示PDF形式でダウンロード (572K) -
V. P. MARSHALL, J. E. MCGEE, J. I. CIALDELLA, L. BACZYNSKYJ, D. G. CHI ...1991 年 44 巻 8 号 p. 895-900
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーAn enzyme (lincosaminide O-nucleotidyltransferase) that catalyzes 3-(5'-ribonucleotidylation) of pirlimycin and several other lincosaminide antibiotics has been purified approximately 35-fold from cell-free extracts of Streptomyces coelicolor Müller NRRL 3532 (UC 5240). The crude enzyme was prepared using lysozyme and was treated with MnCl2 and (NH4)2SO4. Final purification was achieved by anion exchange chromatography. The pirlimycin reaction product was verified as being pirrimycin-3-(5'-adenylate) by NMR spectroscopy and MS. As a result of purification, this lincosaminide nucleotidylating and inactivating enzyme was separated from the macrolide phosphorylating enzyme also present in the cell-free extract.抄録全体を表示PDF形式でダウンロード (312K) -
KUNIAKI TATSUTA, HIDEKAZU OZEKI, MAMI YAMAGUCHI, MASASHI TANAKA, TOSHI ...1991 年 44 巻 8 号 p. 901-902
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (91K) -
II. NEOCARAZOSTATINS A, B AND C, NOVEL FREE RADICAL SCAVENGERSSHINICHIRO KATO, KAZUTOSHI SHINDO, YOKO KATAOKA, YUJI YAMAGISHI, JUNIC ...1991 年 44 巻 8 号 p. 903-907
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (218K) -
NAOKI ABE, NOBUYASU ENOKI, YASUKAZU NAKAKITA, HIDEAKI UCHIDA, RYOICHI ...1991 年 44 巻 8 号 p. 908-911
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (245K) -
KUNIAKI TATSUTA, YOSHIHISA NIWATA, KAZUO UMEZAWA, KAZUNOBU TOSHIMA, MA ...1991 年 44 巻 8 号 p. 912-914
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (195K) -
MASAYA IMOTO, NAOMI SHIMURA, KAZUO UMEZAWA1991 年 44 巻 8 号 p. 915-917
発行日: 1991/08/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (200K)
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