-
SOICHIRO TODA, SATOSHI YAMAMOTO, OSAMU TENMYO, TAKASHI TSUNO, TOSHIFUM ...
1993 Volume 46 Issue 6 Pages
875-883
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
A novel neuritogenetic compound BU-4514N was isolated from the fermentation broth of
Microtetraspora sp. T689-92. It showed significant NGF-mimic activity and antibacterial activity against Gram-positive bacteria. Structural studies revealed that BU-4514N was a new chemotype antibiotic related to lydicamycin.
View full abstract
-
I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES
YUJI YAMAGISHI, MICHIKO MATSUOKA, ATSUO ODAGAWA, SHINICHIRO KATO, KAZU ...
1993 Volume 46 Issue 6 Pages
884-887
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Rumbrin has been isolated from a fungus,
Auxarthron umbrinum, by a screening program designed to find microorganism-produced cytoprotective substances. It was purified by use of column chromatography on silica gel, reversed phase HPLC and then isolated as fine red needles. Rumbrin prevented cell death caused by calcium overload and exhibited a potent inhibitory activity against lipid per oxidation.
View full abstract
-
II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION
YUJI YAMAGISHI, KAZUTOSHI SHINDO, HIROYUKI KAWAI
1993 Volume 46 Issue 6 Pages
888-891
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
The structure of rumbrin (Fig. 1), a new cytoprotective substance, was elucidated by NMR spectral analysis. Rumbrin was found to possess a novel skeleton containing α-pyrone, tetraene and pyrrole moieties.
View full abstract
-
TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES
SHINICHIRO KATO, KAZUTOSHI SHINDO, HIROYUKI KAWAI, ATSUO ODAGAWA, MICH ...
1993 Volume 46 Issue 6 Pages
892-899
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of
Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.
View full abstract
-
I. TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS
YOSHIMI NIHEI, MASAMI HASEGAWA, KIYOSHI SUZUKI, SATOSHI YAMAMOTO, MINO ...
1993 Volume 46 Issue 6 Pages
900-907
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of
Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC
50 6.08μM) without lipid peroxidation.
View full abstract
-
PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
KEIKO FUJIE, YASUHIKO SHINGUH, HIROSHI HATANAKA, NOBUHARU SHIGEMATSU, ...
1993 Volume 46 Issue 6 Pages
908-913
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
A novel human leukocyte elastase inhibitor, FR901277 was discovered in the fermentation broth of
Streptomyces resistomycificus No. 7622. FR901277 has a molecular weight of 961 and a molecular formula of C
47H
63N
9O
13. The mode of inhibition is competitive, with a
Ki of 1.2×10
-8M. Oral administration of FR901277 at doses from 32 to 320mg/kg significantly prevented human leukocyte elastase-induced foot edema in mice.
View full abstract
-
PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITIES
TAKAYUKI AOYAMA, FUKIKO KOJIMA, FUMINORI ABE, YASUHIKO MURAOKA, HIROSH ...
1993 Volume 46 Issue 6 Pages
914-920
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
New benzo[
a]naphthacenequinone metabolites, designated bequinostatins A and B, have been isolated from the culture broth of the benastatin-producing strain
Streptomyces sp. MI384-DF12. The structures of bequinostatins A and B were determined by spectral analyses to be 5, 6, 8, 13-tetrahydro-1, 6, 7, 9, 11-pentahydroxy-8, 13-dioxo-3-pentylbenzo[
a]naphthacene-2-carboxylic acid and 2-decarboxybequinostatin A, respectively. Bequinostatin A showed considerable inhibitory activity against human pi class glutathione
S-transferase (GST π).
View full abstract
-
I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY
YUJI NISHIYAMA, KOKO SUGAWARA, KOJI TOMITA, HARUAKI YAMAMOTO, HIDEO KA ...
1993 Volume 46 Issue 6 Pages
921-927
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
A new antitumor antibiotic verucopeptin was isolated from the culture broth of
Actinomadura verrucosospora Q886-2. It showed potent cytotoxicity and specific
in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D×1 treatment schedule.
View full abstract
-
II. STRUCTURE DETERMINATION
KOKO SUGAWARA, SOICHIRO TODA, TOSHIO MORIYAMA, MASATAKA KONISHI, TOSHI ...
1993 Volume 46 Issue 6 Pages
928-935
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
The structure of a new antibiotic verucopeptin has been determined by the spectroscopic analyses and chemical degradation studies. It is a 19-membered cyclodepsipeptide which is structurally related to azinothricin and A83586C.
View full abstract
-
I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES
MAKOTO UBUKATA, HIROYUKI OSADA, TAKUJI KUDO, KIYOSHI ISONO
1993 Volume 46 Issue 6 Pages
936-941
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Respinomycins are a novel group of anthracycline antibiotics produced by
Sreptomyces xanthocidicus. Respinomycins Al, A2, B, C and D were isolated by EtOAc extraction, silica gel column chromatography, centrifugal partition chromatography and preparative silica gel thin layer chromatography. Respinomycins Al and A2 induced the terminal differentiation of human leukemia K-562 cells.
View full abstract
-
II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION
MAKOTO UBUKATA, JUN UZAWA, HIROYUKI OSADA, KIYOSHI ISONO
1993 Volume 46 Issue 6 Pages
942-951
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Respinomycins A1, A2, B, C and D were revealed to be novel anthracycline antibiotics with molecular formulae of C
51H
72N
2O
20, C
43H
58N
2O
15, C
35H
43NO
14, C
36H
45NO
14 and C
51H
70N
2O
22, respectively. Their structures were determined by means of
1H-
1H COSY,
13C-
1H COSY and HMBC spectra. The structure of the aglycone of respinomycins was unambiguously determined by LSPD experiments and NOESY. The common skeleton of respinomycins is a new type and is distinguished from that of the nogalamycin group.
View full abstract
-
MIKA AOKI, TSUTOMU ANDOH, TOMOKAZU UEKI, SHINJI MASUYOSHI, KOKO SUGAWA ...
1993 Volume 46 Issue 6 Pages
952-960
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
New β-1, 3-glucan synthase inhibitor (BU-4794F) was isolated from the culture broth of
Gilmaniella sp. FA4459. Structural studies indicated that it was a novel member of the papulacandin group of antibiotics.
View full abstract
-
I. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES
MARC STABLER, HEIDRUN ANKE, WOLF-RÜDIGER ARENDHOLZ, FRITZ HANSSKE ...
1993 Volume 46 Issue 6 Pages
961-967
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Several chlorinated metabolites with nematicidal, antimicrobial, and cytotoxic activities were isolated from submerged cultures of the ascomycete
Lachnum papyraceum. Three compounds were identified as (+)-mycorrhizin A (
3), (+)-chloromycorrhizin A (
4) and (+)-dechloromycorrhizin A (
5). The occurrence of
5 as a natural product is new. Two compounds, lachnumon (
1) and lachnumol A (
2), were found to be new fungal metabolites with cytotoxic, nematicidal and antimicrobial activities.
View full abstract
-
II. STRUCTURAL ELUCIDATION
MARC STABLER, HEIDRUN ANKE, KARL-ERIK BERGQUIST, OLOV STERNER
1993 Volume 46 Issue 6 Pages
968-971
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
The structures of two new biologically active chlorinated metabolites isolated from submerged cultures of the ascomycete
Lachnum papyraceum have been elucidated by NMR and mass spectroscopy. The compounds, lachnumon (
1) and lachnumol A (
2), which structurally are related with mycorrhizin A that also is produced by the fungus, contain an unusual chlorinated epoxide group.
View full abstract
-
I. TAXONOMY, FERMENTATION AND BIOLOGICAL ACTIVITY
KAZUO KUMAGAI, KIYOSHI TAYA, AKIO FUKUI, MASATOMO FUKASAWA, MASARU FUK ...
1993 Volume 46 Issue 6 Pages
972-978
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
An actinomycete strain SC-4710, a new soil isolate, was found to produce a new macrolide antibiotic, PC-766B. Chemotaxonomic analysis of the producing organism revealed that the cells of SC-4710 had type IV cell wall, type A whole cell sugar pattern, type PII phospholipids, menaquinone MK-8(H
4), cellular fatty acids comprising straight-chain saturated, unsaturated and tuberculostearic acids, and mycolic acids. The strain was identified as
Nocardia brasiliensis (Lindenberg) Pinoy. The antibiotic, PC-766B, was active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. It also showed antitumor activity against murine tumor cells
in vitro and
in vivo, and a weak inhibitory activity against Na
+, K
+-ATPase
in vitro.
View full abstract
-
II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION OF DELAMINOMYCIN A
MITSUHIRO UENO, TETSUYA SOMENO, RYUICHI SAWA, HIRONOBU IINUMA, HIROSHI ...
1993 Volume 46 Issue 6 Pages
979-984
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of
Streptomyces albulus MJ202-72F3. The structure of delaminomycin A was determined to be 3-[[2-[(3
E, 5
E)-2, 8-dihydroxy-7-methyl-3, 5-decadienyl]-1, 6, 8-trimethyl-1, 2, 4a, 5, 6, 7, 8, 8a-octahydrol-naphthyl]carbonyl]-5-hydroxypyrrolidine-2, 4-dione by analyses of spectral properties and chemical studies.
View full abstract
-
MODIFICATION OF THE SIDE-CHAIN
OSAMU KIKUCHI, TADASHI EGUCHI, KATSUMI KAKINUMA, YASUHIKO KOEZUKA, KAZ ...
1993 Volume 46 Issue 6 Pages
985-991
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Gilvocarcin V was chemically transformed to alter its biological activities as well as its solubility by mainly focusing on the vinyl side chain. The oxirane and oxime derivatives showed slightly decreased
in vivo antitumor activity, while the aminoethylmorpholine derivative turned out to be soluble in some organic solvents.
View full abstract
-
EFFECT OF THE pKa OF THE C-7 AMINOIMIDAZOLE ON ANTIBACTERIAL SPECTRUM AND β-LACTAMASE STABILITY
F. JUNG, D. BOUCHEROT, C. DELVARE, A. OLIVIER, G. M. DAVIES, M. J. BET ...
1993 Volume 46 Issue 6 Pages
992-1012
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
Cephalosporins with new aminoimidazole heterocycles at C-7 have been synthesized by reaction of
anti-α-aminooximes with C-7 dihaloisocyanocephalosporins esters or by direct condensation of 2-fluoroimidazoles with C-7 aminocephalosporins esters. These compounds combine a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive organisms with a good β-lactamase stability. Activity is discussed in terms of its relationship to the
pKa. of the C-7 aminoimidazole heterocycle, basic C-7 aminoimidazole residues gave cephalosporins with the best β-lactamase stability but the poorest activity against Gram-positive organisms. An additional interesting property of the C-7 imidazolylaminocephalosporins is the oral activity present in some compounds of this series.
View full abstract
-
JENS BREINHOLT, HELLE DEMUTH, LENE LANGE, ANDERS KJÆR, CHRISTIAN ...
1993 Volume 46 Issue 6 Pages
1013-1015
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
-
MARVIN SCHULMAN, PATRICK DOHERTY, DEBORAH ZINK, BYRON ARISON
1993 Volume 46 Issue 6 Pages
1016-1019
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
-
III. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION OF DELAMINOMYCINS B AND C
MITSUHIRO UENO, TETSUYA SOMENO, RYUICHI SAWA, HIRONOBU IINUMA, HIROSHI ...
1993 Volume 46 Issue 6 Pages
1020-1023
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
-
III. ISOLATION AND STRUCTURAL ELUCIDATION OF A NOVEL FREE RADICAL SCAVENGER, RESORSTATIN
SHINICHIRO KATO, KAZUTOSHI SHINDO, HIROYUKI KAWAI, MICHIKO MATSUOKA, J ...
1993 Volume 46 Issue 6 Pages
1024-1026
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
-
SUGATA CHATTERJEE, E. K. S. VIJAYAKUMAR, CHRISTOPHER M. M. FRANCO, JUR ...
1993 Volume 46 Issue 6 Pages
1027-1030
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
-
II. STRUCTURAL STUDIES
KIYOTO IMAE, YOSHIMI NIHEI, MASAHISA OKA, TETSURO YAMASAKI, MASATAKA K ...
1993 Volume 46 Issue 6 Pages
1031-1033
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS
-
AKIRA MASUDA, MASAYUKI KITAGAWA, ASAKO TANAKA, SEIICHI SAITO, NOBUYOSH ...
1993 Volume 46 Issue 6 Pages
1034-1037
Published: June 25, 1993
Released on J-STAGE: April 19, 2006
JOURNAL
FREE ACCESS