New antifungal antibiotics, designated as 3874 H1 and H3, were discovered in the fermentation broth of the strain
Streptomyces sp. HAG 003874. The compounds were obtained as yellow powders after sequential purification by chromatography on MCI Gel CHP20P, Fractogel HW-40 and ODS reversed phase chromatography. On the basis of the results of spectroscopic analysis, it was found that 3874 H1, C
58H
86N
2O
18, MW 1098, belongs to the
p-aminoacetophenone containing family of heptaene antibiotics, while 3874 H3, C
57H
87NO
18, MW 1073, is a non-aromatic heptaene. In addition to these, a minor component, 3874 H2, C
59H
88N
2O
18, MW 1112, a
N-methyl derivative of 3874 H1 has been detected. The structures were elucidated through mass spectral analyses and 1-D and 2-D homonuclear and heteronuclear NMR data. The outstanding physico-chemical feature of 3874 H3 is its improved solubility. The new heptaenes are potent antifungal compounds with broad activity spectra, encompassing dermatophytes, yeasts and filamentous fungi.
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