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KEIJI HASUMI, SHIGEKI OHYAMA, TOMOO KOHYAMA, YUKO OHSAKI, RITSUKO TAKA ...
1998 Volume 51 Issue 12 Pages
1059-1068
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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Four novel triprenyl phenol metabolites, designated SMTP-3, -4, -5, and -6, have been isolated from cultures of
Stachybotrys microspora IFO 30018 by solvent extraction and successive chromatographic fractionation using silica gel and silica ODS columns. A combination of spectroscopic analyses showed that SMTP-3, -4, -5, and -6 are staplabin analogs, containing a serine, a phenylalanine, a leucine or a tryptophan moiety in respective molecules in place of the
N-carboxybutyl portion of the staplabin molecule. SMTP-4, -5, and -6 were active at 0.15∼0.3 mM in enhancing urokinase-catalyzed plasminogen activation and plasminogen binding to fibrin, as well as plasminogen- and urokinase-mediated fibrinolysis. On the other hand, the concentration of staplabin required to exert such effects was 0.4∼0.6 mM, and SMTP-3 was inactive at concentrations up to 0.45 mM.
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DAISUKE ISHIYAMA, KATUYUKI FUTAMATA, MATIKO FUTAMATA, OSAMU KASUYA, SH ...
1998 Volume 51 Issue 12 Pages
1069-1074
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus
Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant
Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC
50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.
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Production, Physico-chemical and Biological Properties
BRIGITTE KUNZE, ROLF JANSEN, FLORENZ SASSE, GERHARD HÖFLE, HANS R ...
1998 Volume 51 Issue 12 Pages
1075-1080
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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A novel macrolide, apicularen A, was produced by several species of the genus
Chondromyces. Initially it was discovered by bioassay-guided RP-HPLC-fractionation of culture extracts of
Chondromyces robustus, strain Cm a13. Apicularen A showed no antimicrobial activity, but was highly cytotoxic for cultivated human and animal cells, with IC
50 values ranging between 0.1 and 3 ng/ml. A cometabolite of apicularen A, the
N-acetylglucosamine glycoside apicularen B, was distinctly less cytotoxic with IC
50 values between 0.2 and 1.2 μg/ml, and showed weak activity against a few Gram-positive bacteria. Apicularen A is chemically closely related to the salicylihalamides A and B from the marine sponge
Haliclona sp.
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I. Description of Producing Organism, Fermentation, Isolation, Physico-chemical and Biological Properties
HIROMASA OKADA, SEIGO KAMIYA, YASUKO SHIINA, HIROAKI SUWA, MASAO NAGAS ...
1998 Volume 51 Issue 12 Pages
1081-1086
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain,
Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as
Candida albicans,
Candida glabrata and
Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of
C.
albicans but not of mammalian cells.
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I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
NAOKI MATSUMOTO, ISAO MOMOSE, MAYA UMEKITA, NAOKO KINOSHITA, MAKOTO CH ...
1998 Volume 51 Issue 12 Pages
1087-1092
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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Antibacterial antibiotics, diperamycin (
1) was produced in the culture broth of
Streptomyces griseoaurantiacus MK393-AF2. Various spectroscopic analyses of
1 suggested that
1 belonged to a member of cyclic hexadepsipeptide antibiotic.
Antibiotic
1 had potent inhibitory activity against various Gram-positive bacteria including
Enterococcus seriolicida and methicillin-resistant
Staphylococcus aureus.
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R. W. RICKARDS, J. M. ROTHSCHILD, E. LACEY
1998 Volume 51 Issue 12 Pages
1093-1098
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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An Actinomycete strain A499 belonging to the genera
Amycolatopsis or
Amycolata isolated from a Western Australian soil sample produced the cyclic decapeptide antibiotic quinaldopeptin (
1), together with the actinotetraose hexatiglate (
2), the hexa-ester of a novel non-reducing glucotetraose.
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KEN-ICHI KIMURA, YOSHIKAZU IKEDA, SHINOBU KAGAMI, MAKOTO YOSHIHAMA, KA ...
1998 Volume 51 Issue 12 Pages
1099-1104
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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We examined the inhibitory activity against bacterial peptidoglycan biosynthesis, mammalian glycoprotein biosynthesis and growth of BALB/3T3 cells of four different types of liposidomycins which have the structure with or without sulfate and/or 3-methylglutaric acid moieties. Liposidomycins inhibited peptidoglycan biosynthesis about 30∼500 times more effectively than tunicamycin, whereas liposidomycins inhibited mammalian glycoprotein biosynthesis about 30∼300 times less effectively than tunicamycin. When the cytotoxic effect of liposidomycins and tunicamycin on the growth of mammalian cells were compared, liposidomycins did not show toxicity against BALB/3T3 cell at 25 μg/ml, though tunicamycin inhibited cell growth by 50% at 0.05 μg/ml. On the basis of these results, it is concluded that liposidomycins are selective antibiotics showing highly specific inhibition toward bacterial peptidoglycan biosynthesis.
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NORIYUKI YAMASHITA, KAZUO SHIN-YA, KAZUO FURIHATA, YOICHI HAYAKAWA, HA ...
1998 Volume 51 Issue 12 Pages
1105-1108
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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Biological and Mechanistic Activities
M. P. SINGH, J. ZACCARDI, M. GREENSTEIN
1998 Volume 51 Issue 12 Pages
1109-1112
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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III. Absolute Configuration of an Antifungal Antibiotic, UK-2A, and Consideration of Its Conformation
KOZO SHIBATA, MUHAMMAD HANAFI, JYUNKO FUJII, OSAMU SAKANAKA, KATSUHARU ...
1998 Volume 51 Issue 12 Pages
1113-1116
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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I. Synthesis and Biological Activity of 7-[2-(2-Aminothiazol-4-yl)-2-(alkoxy)-iminoacetamido] Derivatives
KYUNG IL CHOI, JOO HWAN CHA, AE NIM PAE, YONG SEO CHO, MOON HO CHANG, ...
1998 Volume 51 Issue 12 Pages
1117-1121
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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II. Synthesis and Biological Activity of 7-[2-(2-Aminothiazol-4-yl)-2-hydroxy-iminoacetamido] Derivatives
KYUNG IL CHOI, JOO HWAN CHA, AE NIM PAE, YONG SEO CHO, YOUSEUNG KIM, M ...
1998 Volume 51 Issue 12 Pages
1122-1125
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
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HIDEAKI KAKEYA, MASAYUKI MORISHITA, KIMIE KOBINATA, MICHIYO OSONO, MAS ...
1998 Volume 51 Issue 12 Pages
1126-1128
Published: December 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL
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