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Volume 51, Issue 4
Displaying 1-12 of 12 articles from this issue
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ECKHARD THINES, HEIDRUN ANKE, OLOV STERNER1998 Volume 51 Issue 4 Pages 387-393
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSFrom submerged cultures of Scytalidium sp. 36-93, ten metabolites were isolated due to their effects on dihydroxynaphthalene (DHN) or DOPA melanin biosynthesis. Four of the compounds, scytalols A (1a), B (1b), C (2), and D (3), are new secondary metabolites, the structures of which were determined by spectroscopy, while the other compounds are known. Scytalols A (1a) and D (3) are selective inhibitors of DHN melanin biosynthesis and exhibit no antifungal or cytotoxic activities. Nectriapyrone, 6-methoxymellein and 4-chloro-6-methoxymellein stimulated the formation of DOPA melanin in B16-F1 melanoma cells in the absence of melanin-stimulating hormone.View full abstractDownload PDF (972K) -
I. Taxonomy, Fermentation, Isolation and Physico-chemical and Biological PropertiesTAKAYUKI KAJIURA, TAMOTSU FURUMAI, YASUHIRO IGARASHI, HIROSHI HORI, KA ...1998 Volume 51 Issue 4 Pages 394-401
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSStrain TP-A0121 which produces a complex of novel tyrosine kinase inhibitors designated hibarimicins A, B, C, D and G was considered to be a new subspecies of Microbispora rosea, and the name, Microbispora rosea subsp. hibaria, was proposed. Hibarimicins A, B, C and D specifically inhibited the src tyrosine kinase activity without affecting protein kinase A or protein kinase C. They also showed in vitro anti-Gram-positive bacterial and antitumor activities. The molecular formulae of hibarimicins A, B, C, D and G were assigned to be C85H112O37, C85H112O37, C83H110O36, C85H112O38, and C85H112O39 respectively.View full abstractDownload PDF (1894K) -
II. Structural StudiesHIROSHI HORI, YASUHIRO IGARASHI, TAKAYUKI KAJIURA, TAMOTSU FURUMAI, KA ...1998 Volume 51 Issue 4 Pages 402-417
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSThe structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin BView full abstractDownload PDF (1960K) -
Chemical Interrelation with a Homologous Peptide, Ustiloxin BYUKIKO KOISO, NAOKO MORISAKI, YUKIKO YAMASHITA, YUKIKO MITSUI, RYUICHI ...1998 Volume 51 Issue 4 Pages 418-422
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSUstiloxin F, a microtubule inhibitor, was isolated as a minor metabolite of Ustilaginoidea virens. The structure was determined from the spectral data and by chemical interrelation to ustiloxin B through reductive removal of the sulfoxide-containing side chain of ustiloxin B to give ustiloxin F. Ustiloxin F inhibited microtubule assembly with an IC50 value of 10.3 μM.View full abstractDownload PDF (482K) -
NAOKO MORISAKI, YUKIKO MITSUI, YUKIKO YAMASHITA, YUKIKO KOISO, RYUICHI ...1998 Volume 51 Issue 4 Pages 423-427
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSUstiloxin D, produced by the rice plant pathogen Ustilaginoidea virens, exhibits potent anti-tubulin activity. In order to elucidate the effects of functional groups in ustiloxin D on its activity, several derivatives were synthesized and their anti-tubulin activities were estimated. The N, N-dimethylamino derivative and the 14-O-methyl derivative were inactive (IC50>50 μM). 20-Hydroxymethylated ustiloxin D showed decreased inhibitory activity compared with ustiloxin D.View full abstractDownload PDF (506K) -
TATSUO TANIMOTO, SATOSHI OHYA, YOSHIO TSUJITA1998 Volume 51 Issue 4 Pages 428-431
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSRecently we found novel zaragozic acids (ZAs), F-10863A (zaragozic acid D3, ZAD3), B, C and D in the culture broth of the fungus Mollisia sp. SANK 10294 as potent inhibitors of squalene synthase. There are several other enzymes that use farnesylpyrophosphate as their substrate. Among them we chose farnesyl-protein transferase and examined whether ZAD3 and F-10863B inhibit this enzyme's activity. ZAD3 and F-10863B inhibited farnesyl-protein transferase with IC50 values of 0.60 and 3.7 μM, respectively. They also inhibited geranylgeranyl-protein transferase at similar concentrations. In addition, they exhibited potent antifungal activity.View full abstractDownload PDF (436K) -
TARO AMAGATA, KATSUHIKO MINOURA, ATSUSHI NUMATA1998 Volume 51 Issue 4 Pages 432-434
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSDownload PDF (311K) -
TAKEO SUGAWARA, AKIHIRO TANAKA, KOICHI TANAKA, KOJI NAGAI, KENICHI SUZ ...1998 Volume 51 Issue 4 Pages 435-438
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSDownload PDF (396K) -
Production, Isolation, Structure Elucidation and Biological PropertiesTRIPTIKUMAR MUKHOPADHYAY, R. G. BHAT, KIRITY ROY, E. K. S. VIJAYAKUMAR ...1998 Volume 51 Issue 4 Pages 439-441
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSDownload PDF (343K) -
HIROYUKI ONUKI, HARUMI MIYASHIGE, HIROSHI HASEGAWA, SHINYA YAMASHITA1998 Volume 51 Issue 4 Pages 442-444
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSDownload PDF (353K) -
TOSHIYUKI KAMIGAUCHI, RYUJI SAKAZAKI, KAZUO NAGASHIMA, YOSHIMI KAWAMUR ...1998 Volume 51 Issue 4 Pages 445-450
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSDownload PDF (536K) -
YOSHITAKE TANAKA, FANG FANG, CHENG GANG ZHANG, XIAN WU ZHANG, SATOSHI ...1998 Volume 51 Issue 4 Pages 451-453
Published: April 25, 1998
Released on J-STAGE: January 27, 2009
JOURNAL FREE ACCESSDownload PDF (388K)
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