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Volume 53, Issue 11
Displaying 1-13 of 13 articles from this issue
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I. Taxonomy, Production, Isolation and Biological PropertiesNORIHIRO KAKINUMA, HIROKI IWAI, SENJI TAKAHASHI, KUNIKATSU HAMANO, TAD ...2000 Volume 53 Issue 11 Pages 1247-1251
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSQuinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp. from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against tumor necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).View full abstractDownload PDF (461K) -
II. Physico-chemical Properties and Structure ElucidationSENJI TAKAHASHI, NORIHIRO KAKINUMA, HIROKI IWAI, TADASHI YANAGISAWA, K ...2000 Volume 53 Issue 11 Pages 1252-1256
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSThree novel quinolone compounds, quinolactacins A (1), B (2) and C (3), Have been found from the fermentation broth of Penidllium sp. EPF-6, a fungus isolated from the larvae of mulberry pyralid (Margaronia pyloalis Welker). The molecular formulas of 1, 2 and 3 were determined to be C16H18N2O2, C15H16N2O2 and C16H18N2O3, respectively by FAB-MS and NMR spectral analyses. The structures of these compounds have a novel quinolone skeleton with a γ-lactam ring consisting of C12H8N2O2 as the common chromophore.View full abstractDownload PDF (327K) -
HIROSHI KANZAKI, SATOHIRO YANAGISAWA, TERUHIKO NITODA2000 Volume 53 Issue 11 Pages 1257-1264
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSThe cell-free extract of an albonoursin-producing strain Streptomyces albulus KO-23 catalyzes the conversion of cyclo(L-Leu-L-Phe) (1) to albonoursin (2). At the early stage of this conversion, two compounds were newly formed prior to albonoursin synthesis in the reaction mixture. These compounds were isolated and identified as (Z)-3-benzylidene-6-isobutyl-2, 5-piperazinedione (4) and (Z)-3-benzyl-6-isobutylidene-2, 5-piperazineclione (3). The cell-free extract also catalyzed the conversion of compound 3 or 4 to albonoursin. From these results, albonoursin was found to be biosynthesized via these compounds from cyclo(L-Leu-L-Phe). These didehydro diketopiperazines exhibited no inhibitory activity toward the first cleavage of sea urchin embryo in contrast to the higher cytotoxicity for albonoursin, indicating that dehydrogenation at α, β-positions of both amino acid residues in diketopiperazines is required for cytotoxicity.View full abstractDownload PDF (495K) -
SHOHEI SAKUDA, MAKOTO ONO, HIROYUKI IKEDA, TAKEFUMI NAKAMURA, YASUHITO ...2000 Volume 53 Issue 11 Pages 1265-1271
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSBlasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μM.View full abstractDownload PDF (506K) -
SCOTT J. HECKER, TOMASZ W. GLINKA, AESOP CHO, ZHIJIA J. ZHANG, MARY E. ...2000 Volume 53 Issue 11 Pages 1272-1281
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSThe discovery of RWJ-54428 (MC-02, 479), a new cephalosporin displaying promising activity against sensitive and resistant Gram-positive bacteria, is described. Progressive structural modification from the previously reported 3-phenylthiocephem MC-02, 331 afforded an overall increase in potency against MRSA while retaining other key properties such as acceptable solubility and serum binding. Evaluation of the in vitro potency and in vivo efficacy of a series of closely related compounds resulted in selection of RWJ-54428 (MC-02, 479) for further studies.View full abstractDownload PDF (528K) -
JOHN M. BERGE, NIGEL J. P. BROOM, CATHERINE S. V. HOUGE-FRYDRYCH, RICH ...2000 Volume 53 Issue 11 Pages 1282-1292
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSSB-219383 is a naturally occurring antibiotic, which acts by inhibition of tyrosyl tRNA synthetase. Semi-synthetic derivatives of SB-219383 were prepared with the objective of elucidating the key features required for inhibition of tyrosyl tRNA synthetase in order to improve the antibacterial activity. Some ester and amide derivatives as well as monocyclic analogues exhibited sub-nanomolar inhibitory activity against tyrosyl tRNA synthetase.View full abstractDownload PDF (717K) -
ALBRECHT BERG, HELMAR GÖRLS, HEINRICH DÖRFELT, GRIT WALTHER, ...2000 Volume 53 Issue 11 Pages 1293-1295
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSDownload PDF (179K) -
OSAMU NOZAWA, TADAYASU OKAZAKI, SHIGEO MORIMOTO, ZENG-XIANG CHEN, BI-M ...2000 Volume 53 Issue 11 Pages 1296-1300
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSDownload PDF (275K) -
JUN KOHNO, MAKI NISHIO, NOBORU KISHI, TORU OKUDA, SABURO KOMATSUBARA2000 Volume 53 Issue 11 Pages 1301-1304
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSDownload PDF (189K) -
CHANG-SEOK LEE, SEONG HO OH, EUN-JUNG RYU, MU-YONG KIM, KYUNG-SOOK PAE ...2000 Volume 53 Issue 11 Pages 1305-1309
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSDownload PDF (242K) -
TOSHIO TAKATSU, MASAHIKO OHTSUKI, AKIKO MURAMATSU, RYUZO ENOKITA, SHIN ...2000 Volume 53 Issue 11 Pages 1310-1312
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSDownload PDF (252K) -
ALBRECHT BERG, KATHRIN REIBER, HEINRICH DORFELT, GRIT WALTHER, BRIGITT ...2000 Volume 53 Issue 11 Pages 1313-1316
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSDownload PDF (201K) -
NOBUTAKA IMAMURA, IZUMI MOTOIKE, MASAHIRO NODA, KYOUKO ADACHI, AYA KON ...2000 Volume 53 Issue 11 Pages 1317-1319
Published: November 25, 2000
Released on J-STAGE: September 19, 2008
JOURNAL FREE ACCESSDownload PDF (179K)
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