A marine bacterium
Ruegeria atlantica (designated as strain TUF-D) was isolated from a glass plate submerged in the coastal water. Three new chlorine containing compounds (
1-3) together with penicillic acid (
4) were obtained from a marine-derived fungus
Aspergillus ostianus strain TUF 01F313 isolated from a marine sponge at Pohnpei as antibacterial components against
R. atlantica. The structures of three new antibiotics were determined based on their spectral data as 8-chloro-9-hydroxy-8, 9-deoxyasperlactone (
1), 9-chloro-8-hydroxy-8, 9-deoxyasperlactone (
2), and 9-chloro-8-hydroxy-8, 9-deoxyaspyrone (
3). Compound
1 inhibited the growth of
R. atlantica at 5μg/disc (inhibition zone: 12.7mm), while
2 and
3 were active at 25μg/disc (10.1 and 10.5mm, respectively).
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