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EIRO TSUBURA, HEIHAKU TSUJIMOTO, TERUO TACHIBANA, MASAMICHI HARA, YASU ...
1970 Volume 23 Issue 2 Pages
99-102
Published: April 25, 1970
Released on J-STAGE: May 17, 2013
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FUMIO MIKI, TOMOTSUGU AZUMA, TAKASHI IWASAKI, MITSURU AKAO, TATSUO OZA ...
1970 Volume 23 Issue 2 Pages
103-106
Published: April 25, 1970
Released on J-STAGE: May 17, 2013
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YASUO FUJIMOTO
1970 Volume 23 Issue 2 Pages
107-108
Published: April 25, 1970
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SUSUMU NAKAZAWA, SHU OKA, HAJIME SATO, HAJIME ENDO
1970 Volume 23 Issue 2 Pages
109-115
Published: April 25, 1970
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YOSHIO KOBAYASHI, HIDEKO ITO, ROKURO OKUDA, YUTAKA KOBAYASHI
1970 Volume 23 Issue 2 Pages
116-122
Published: April 25, 1970
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MOMOJI YABUUCHI, OSAMU NAKAMURA
1970 Volume 23 Issue 2 Pages
123-126
Published: April 25, 1970
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TADAO NISHIMURA, YASUSHI KOTANI, YASUNORI ASATANI
1970 Volume 23 Issue 2 Pages
127-130
Published: April 25, 1970
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MAKOTO MINO, KIZABURO KANO, SHINOBU HIGAMI
1970 Volume 23 Issue 2 Pages
131-133
Published: April 25, 1970
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KATSUJI SAKAI, MASAHIRO NAGAHISA, JUN-ICHI NAKAO
1970 Volume 23 Issue 2 Pages
134-135
Published: April 25, 1970
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MASANOBU MAEKAWA, SABURO KONO
1970 Volume 23 Issue 2 Pages
136-141
Published: April 25, 1970
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JYOJI ISHIGAMI, SHINJI HARA, TOSHIHIKO MITA
1970 Volume 23 Issue 2 Pages
142-147
Published: April 25, 1970
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MASAHIKO TAKAHASH
1970 Volume 23 Issue 2 Pages
148-151
Published: April 25, 1970
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TOYOKO OGURI, NOZOMU KOSAKAI
1970 Volume 23 Issue 2 Pages
152-156
Published: April 25, 1970
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We examined the species and drug-susceptibility of the anaerobes isolated from various clinical meterials for a period of about eight years from July 1961 to December 1968.
Among 6, 208 positive cultures obtained from pus and secretes, the anaerobes were yielded in 15.6%. In fact the anaerobes were yielded in pure culture in only 3.6% and the remaining 12.0% showed the anaerobes as well as some aerobes.
As far as the species of the anaerobes isolated from pus and secretes are concerned, 35.0% were ocuppied by Gram-positive cocci, and 34.8% by Gram-negative bacilli. In contrast, the clostridia ocuppied only 4.1%.
Then, susceptibility of these anaerobes to antibiotics was studied with disc method. Except for Gramnegative bacilli, almost all anaerobes isolated were sensitive to penicillin G, ampicillin and cephaloridine. About 90 % or more of the anaerobes were sensitive to chloramphenicol and tetracycline. Erythromycin, leucomycin and lincomycin were effective not only on Gram-positive bacilli and cocci, but also effective considerably on Gram-negative bacilli. In contrast, streptomycin and kanamycin were ineffective to the anaerobes isolated.
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NOBUHIKO KOMATSU, SACHIE OKUBO, SHOICHI KIKUMOTO
1970 Volume 23 Issue 2 Pages
157-160
Published: April 25, 1970
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Nutritional studies on
Schizophyllum commune for the production of schizophyllan, a viscous glucan with host-mediated antitumor activities against subcutaneously transplanted tumors, have been carried out.
1) Schizophyllan could be produced in synthetic media as well as in complex media.
2) Thiamine hydrochloride proved to show marked stimulating action on both growth of mycelia and production of schizophyllan in synthetic media.
3)
Schizophyllum commune required the pyrimidine portion of thiamine molecule as the growth factor.
4) Inorganic nitrogen compounds could not be generally utilized as the nitrogen source. Organic nitrogen compounds such as urea and amino acids, especially sodium glutamate, were suitable for the production of schizophyllan.
5) Among the carbon sources tested, ethylene glycol, glycerol, ribose, arabinose, xylose, galactose and lactose could not be utilized or could be poorly utilized. Glucose, fructose, mannose, maltose, sucrose and starch could be effectively utilized.
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YUTAKA KANAZAWA, TOSHIO KURAMATA
1970 Volume 23 Issue 2 Pages
161-165
Published: April 25, 1970
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SHUNJI OTA, ATSUSHI HAMAGAMI, YOSHIRO TERAWAKI, RINTARO NAKAYA
1970 Volume 23 Issue 2 Pages
166-170
Published: April 25, 1970
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I. Effect on experimental tumors
BUNZO NOMIYA, KEINOSUKE KAGINO, YOSHINORI ORIKASA, HARUMI FUJIMORI
1970 Volume 23 Issue 2 Pages
171-180
Published: April 25, 1970
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II. Effect ascites tumor cellsin vivo
BUNZO NOMIYA, KEINOSUKE KAGINO, YOSHINORI ORIKASA, HARUMI FUJIMORI
1970 Volume 23 Issue 2 Pages
181-188
Published: April 25, 1970
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TADAMI FUKUSHIMA, HISAAKI OCHIAI, TSUYOSHI AKAISHI, MIEKO MORIYA
1970 Volume 23 Issue 2 Pages
189-194
Published: April 25, 1970
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RINJI KAWANA, KUNIO NAKAMURA, TAKESHI YOSHIDA
1970 Volume 23 Issue 2 Pages
195-198
Published: April 25, 1970
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[in Japanese], MANABU ITO
1970 Volume 23 Issue 2 Pages
199-202
Published: April 25, 1970
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TAKEHIKO IWASAWA, TSUTOMU KIDO
1970 Volume 23 Issue 2 Pages
203-212
Published: April 25, 1970
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We have recently obtained the result described below thorugh the foundational and clinical studies on cephalexin.
(1) The minimum inhibitory concentration of cephalexin was measured by an agar plate dilution method. Cephalexin inhibited the growth of 60 strains of coagulase-positive
Staphylococcus aureus at 1.56-6.25mcg/ml. Both gram-positive and gram-negative bacteria were almost equally sensitive to cephalexin.
(2) The blood concentration of cephalexin was determined in 3 adult cases. The maximal level reached 14.5mcg/ml on the average two hours after a single oral administration of 500mg, and the level was still 1.04mcg/ml in six hours after the administration.
(3) The urinary excretion of cephalexin was studied in 3 adult cases. The rate of urinary recovery showed a high level such as 81.3% of the total dosage.
(4) In the clinical test of cephalexin in otorhinolaryngological infections, it was found that the results were good in 33 cases of 38 (87%) by oral administration of 750-2,000mg per day.
(5) The comparative examinations of liver, electrocyte and audiogram before and after administration showed no significant disturbances. Cephalexin showed no side effect at all clinical administration.
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