All issues
Predecessor
Volume 29, Issue 7
Displaying 1-4 of 4 articles from this issue
- |<
- <
- 1
- >
- >|
-
GRANULES IN PEDIATRICSSUSUMU NAKAZAWA, HAJIME SATO, SHODO FUJII, SEKIYA KOJIMA, YUICHI HIRAM ...1976 Volume 29 Issue 7 Pages 695-700
Published: July 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAmoxicillin granule (100mg AMPC potency per 1.0g granule) was administered to pediatric patients with the following results.
1) AMPC serum concentration and the urinary recovery of two preparations (Clamoxyl ‘Beecham’and Sawacillin ‘Fujisawa’) granule were compared in a cross over trial in 5 healthy adult volunteers. No significant difference in the results was observed between the two granules.
2) The peak serum concentration after oral administration of 10mg/kg AMPC to 5 children gave an average of 5.06μg/ml 1 hour after administration. The 6-hour urinary excretion was distributed 51.4-78.9%.
3) AMPC was administered at a dose of about 20mg/kg/day to 35 children with acute pediatric infections that is scarlet fever, acute tonsillitis, tonsillitis lacunalis, acute bronchitis, bronchial asthma +bronchitis and infectious impetigo. An effective therapeutic result was obtained in all cases.
4) The granule was well accepted by young children, and at a dose level of about 20mg/kg/day for a week no disorder on hepatorenal function was observed in any of the patients.View full abstractDownload PDF (634K) -
YUTAKA KANAZAWA, TOSHIO KURAMATA1976 Volume 29 Issue 7 Pages 701-705
Published: July 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
KUNIO TOMIMASU, HIRONORI TOMINAGA1976 Volume 29 Issue 7 Pages 706-710
Published: July 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSVastcillin granules ‘Takeda’, a cyclacillin (AC-PC) preparation for children were orally administered to nine children at a single dose of 10mg/kg and its blood concentrations and urinary excretion were studied. From the results obtained, the following conclusions were obtained as to clinical dose and indications.
(1) Absorption of AC-PC of Vastcillin granules is excellent. At 15 minutes after administration, 9.3mcg/ml of AC-PC blood level was attained and its peak appeared 30 minutes after administration. The mean peak level was 17.6mcg/ml.
(2) Urinary excretion was highest during the first 2 hours after administration. The mean urinary recovery during 6 hours after administration was 52.6% of the given dose.
(3) In case that the causative organisms are gram-positive bacteria such as Staphylococcus aureus, administration of 10mg/kg or a little more three to four times per day is to be considered adequate.
(4) Vastcillin is most effectively indicated for respiratory-tract infections which are mainly caused by gram-positive bacteria and is expected to be effectively indicated for urinary-tract infections.View full abstractDownload PDF (758K) -
TADASHI FURUHATA, YOSHIAKI KATABA, KEIICHIRO YAMAMOTO, TADAHIRO WATANA ...1976 Volume 29 Issue 7 Pages 711-714
Published: July 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
- |<
- <
- 1
- >
- >|