Bacimethrin, 2-methoxy-4-amino-5-hydroxymethyl pyrimidine, was isolated from the culture broth of a strain of Bacillus megaterium1,2). The antibacterial activity was reversed by vitamin B1 or B6. The activity against experimental infections of Staphylococcus aureus and Salmonella enteritidis was examined in mice. The effects on neoplasmic growth and on viral multiplication were also investigated. The results are presented in this publication.
Monazomycin, another new antibiotic, was obtained from a culture beer of Streptomyces mashiuensis. It had toxicity to mice and inhibited growth of Bacilli and Mycobacteria. The activity against transplantable mouse tumors was studied and the results are described in this paper.
Stendomycin, a new antifungal antibiotic, has been obtained from a streptomycete isolated from soil. This communication will describe the organism and medium employed for the production of stendomycin, the isolation procedures, and some of the physical, chemical, and biological properties of the purified antifungal antibiotic.
In the course of searching for antitumor antibiotic using the Ehrlich ascites tumor, we found an effective substance from the filtrate of a new kind of Streptomyces sp. 13-90 which was isolated from the soil collected at Yumoto-machi in Oga Peninsula, Akita Prefecture. We have named it “cervicarcin”, K. Ohkuma, et al.1) have reported on its isolation and physico-chemical properties and C. Itakura, et al.2) on its antitumor effect. This paper deals with the microbiological characteristics of cervicarcin-producing organism, Streptomyces sp. 13-90.
The organism producing tuberin, designated 10-101 in our culture collection, was isolated from a soil sample collected in Amakusa Island in Japan.
This paper describes taxonomic studies of the organism. Fermentation, isolation and characterization of the antibiotic, chemical structure as well as synthesis of tuberin have heed described elsewhere.1,2,3)