Cholinesterase activity of the central nervous system was histochemically investigated in rodents (mice, rats, guinea pigs and rabbits) by using the KOELLE 3rd method. The result were as followed.
1. The pattern of cholinesterase distribution is remarkably similar but the intensity of activity somewhat differs in the animal species, being highest in mice and rats, intermediate in guinea gigs and lowest in rabbits.
2. The most intense reaction is given in the caudate nucleus, putamen, amygdaloid nuclei (especially pars posterior of the nucleus lateralis), tuberculum olfactorium, optic tectum, interpeduncular nucleus, locus caeruleus, nucleus ambiguus. An moderately intense activity occurs in the 1st layer of the neocortex, nucleus accumbens septi, diagonal band of BROCA, subfornical body, nucleus habenulae, anterior ventral nucleus of the thalamus, reticular nucleus, fasciculus retroflexus, nuclei pontis, nucleus lemnisci lateralis and most of the cranial nerve nuclei. An intermediate staining is exhibited in the neccortex, olfactory bulb, anterior dorsal nucleus of the thalamus, posterior nucleus of the thalamus, nucleus paraventricuralis, nucleus supraopticus, red nucleus, DEITERS' nucleus, granular layer of the cerebellum, inferior olivary nucleus, the GOLL and BURDACH nuclei and the floor of the fourth ventricle.
A low activity is present in the substantia nigra, superior olivary nucleus and main sensory nucleus of fifth nerve.
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