アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
10 巻, 2 号
選択された号の論文の10件中1~10を表示しています
  • 原稿種別: 目次
    1961 年 10 巻 2 号 p. 1-4
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
  • 村井 ウタ
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 123-130,195
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    The vehicular function of leukocyte of the antigenic substances was investigated in the food allergy and the drug (irgapyrin) allergy by means of the same methods as described in the report 1. The leucocytes were obtained from the healthy persons before and after taking an usual meal, raw eggs, or irgapyrin. The leukocytes thus obtained were injected intracutaneously to healthy persons and patients having various diseases. Positive skin reactions were specifically observed in patients with the beaf allergy when the leucocytes obtained after taking an usual meal were used. Positive reactions to the raw eggs were observed in the cases of food (chiefly egg) allergy and irgapirin positive reactions were observed in patients with irgapirin allergy. Passive transfer skin tests between the sera of patients with egg allergy and the leucocytes obtained from a healthy persons after taking eggs were positive. The above mentioned reactions seemed to be more remarkable when lymphocytes were used than the case of granulocytes. It is suggested that leucocytes, especially lymphocytes, have a property to combine with the antigenic food proteins or chemical drugs and serve for the transportation of it.
  • 三宅 健夫
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 131-143,195
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    Histochemical observations on the repair process of connective tissue in the Arthus phenomenon were carried out. Connective tissue repair process may be classified to six phases as follows. Namely, a) tissue necrosis b) stadium of fibloblast proliferation c) stadium of ground substance and Ag-fiber proliferation d) stadium of mast cell proliferation and collagen synthesis e) maximum stadium of collagen fiber formation f) complete stadium of repair process. Bundle formation of Ag-fibers was presently stainable with van Gieson's stain in the presence of mast cell. The actions of mast cell have not yet been Known. However, it may be seen to have intimate relations with collagen fiber formation. By administration of Glycyrrhizine to the Arthus phenomenon, leucocyte infiltration was decreased, and fibrin infiltration was increased. After 48〜72 hours, fibrin was entirely disappeared, and perivascular infiltrations of lymphocytes were remarkable. In the granulation tissue, mast cells were dominantly increased, with large protoplasma and great store of metachromatic granules, and bundle formations from Ag-fibers to collagen fiber were abundant.
  • 青木 良明
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 144-147,196
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    In an attempt to ascertain the antigenicity of Mollusca protein, experimental studies have been made in rabbits with extracts of the muscle of the wreath shell. The protein pattern of this extract was observed as a simple band between β and γ globulin of human serum in paper electrophoresis. When the rabbits were sensitized with the Turbo extract, precipitin against this extract was detected in serum of all rabbits. When experimental allergies were produced with the mixture of this extract and red cell cephaline as an antigen, severe anemia were found transiently after the reinjection, i.e. Erythron-Allergy was occurred, but anaphylactic shock syndrome were hardly observed.
  • 青木 良明
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 148-155,196
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    In order to investigate the antigenicity of extracts from Turbo cornutus in tissue allergy. several experiments were performed in rabbits using the mixture of Turbo extracts and liver phosphatide for sensitization and reinjection. After the reinjection, severe anemia and the disturbances in liver function were observed, as Cobalt-, Lugol-and C.C.F.- tests became positive and urinary urobilinogen increased. Remarkable histological changes in the liver were seen, i.e. the swelling of liver cells, pale cytoplasm with many granules and vacuoles. It is thought that Turbe extracts have higher affinity for liver cells in tissue allergy than ox serum, and that the different degree of the affinity between Turbo extracts and ox serum may be due to higher contents of mucoplysaccharides in Turbo extracts than in ox serum. The anemia observed after reinjection had hypoplastic characters in nature, but partly some hemolytic pattern, was seen.
  • 青木 良明
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 156-161,196-19
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    Experiments were planned to determine the pathogenesis of the anemia in liver allergy described previously (in II nd report). Normal rabbits were injected with the serum or the liver emulsion of the rabbits of experimentaly induced liver allergy. Then, severe anemia with a distinct hemolytic pattern were induced by each injection, but no remarkable changes were seen histologically and functionally in the liver. This might be caused by auto antibodies against red cell that may be contained in the serum or the liver emulsion of the rabbits which were suffering from the liver allergy induced by injecting the mixture of Turbo extracts and liver phosphatide.
  • 高橋 昭三, 谷江 澄子, 立花 祺朗
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 162-168,197
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    Skin test to house dust extract and leucocytolysis in vitro in the presence of house dust extract were investigated in the patients with bronchial asthma and non-asthmatics. Furthermore, the authors summarized the results of hyposensitization therapy with house dust extract in asthmatics and also investigated whether a blocking antibody would be produced following this therapy or not. The results obtained were as follows: 1) The crude house dust extract showed positive skin reactions in 78.4% of the asthmatics, and the obvious difference of skin reactivity was observed between the asthmatics and the nonasthmatics. The purified house dust extract by acetone fractionation exhibited about equal skin reactivity in the asthmatics, but in the non-asthmatics the positive skin reactions to the latter were less more frequent than those to the former and the purification by acetone fractionation of crude house dust extract appeared to increase the allergen specifity. 2) The leucocytolysis in vitro proved positive in 41.7% of the asthmatic patients, and no relationship was shown between the leucocytolysis and the skin reactions. 3) The results of specific hyposensitization treatment were satisfactory, and excellent effects were observed in 24.5% of the patients who received the treatment and good or fair cases in 51.9%. 4) Five of the thirteen sera from the patients received specific hyposensitization treatment possessed a substance which showed no loss of its reagin-binding capacity after heated to 56℃ for 4 hours and appeared to be a blocking-antibody.
  • 高橋 統一
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 169-177,197-19
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    Two groups of guinea pigs were sensitized with E. coli 0-13 or Sh. flexneri 2b with adjuvant or not respectively. Leucocytes were isolated and pooled from the blood of the sensitized guinea pigs and the tissue culture type test of leucocytes were performed by applying the respective antigens. The tissue culture type test of leucocytes were negative, when the leucocytes obtained from the group of the guinea pigs sensitized by the use of adjuvant were used, though Schultz-Dale reaction of the isolated guinea pig intestine of the group were positive. However, the test was positive, when the leucocytes isolated from the group sensitized without adjuvant were used and Schultz-Dale reaction of the isolated guinea pig intestine of this group were almost positive.
  • 大橋 静
    原稿種別: 本文
    1961 年 10 巻 2 号 p. 178-194,198
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
    Aus den statistischen Untersuchungen unserer Arznei-exanthemfalle ergab sich folgendes: Bei Mannern treten sie nicht so vorwiegend auf als bei Frauen. Bei Antipyretica und Sulfonamide usw. Kommen sie hauptsachlich als fixes Exanthem und bei Antiphthisica (Streptomyzin, PAS u.a.m), sowie bei Salvarsan, als Erythrodermie oder pemphigusartiges Exanthem vor. Im grossen und ganzen war die positive probe von per os bei fixem Exanthem und der positive Epikutantest bei Erythrodermie nachweisbar. Histologisch liess sich erkennen, dass das Zentrum der Veranderung scheinbar in Papille der Cutis liegt. Aber auch die starke Veranderung wurde in der Epidermis-intraepidermale Blase-beobachtet. Daraufhin ist es vermutlich nicht feststellbar, ob in Epidermis oder Cutis das Zentrum der Veranderung liegt. Sowohl bei Eruption von vielen Fallen, als auch bei Tierexperimenten wurde Grampositive Fasern von Prof. Noguchi festgestellt. Daraus ist geschlossen worden, dass sich sog. hyperergische oder exsudative Entzundungen bei Arzneiexanthem befinden (Autoreferat).
  • 原稿種別: 文献目録等
    1961 年 10 巻 2 号 p. 195-198
    発行日: 1961/02/28
    公開日: 2016/10/20
    ジャーナル フリー
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