アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
10 巻, 4 号
選択された号の論文の9件中1~9を表示しています
  • 原稿種別: 目次
    1961 年 10 巻 4 号 p. 1-4
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
  • 高見 勝衛
    原稿種別: 本文
    1961 年 10 巻 4 号 p. 247-252,292
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
    Rabbits and guinea pig were sensitized with egg-white and shocked by the injection of the antigen. The shock was neither prevented nor weakened by cutting vagal nerves, extirpation of Ggl. stellata or artificial respiration. The death due to shock was sometimes prevented, when the blood-pressure was kept so as not to be falled by the continuous infusion of 10^<-5>g/ml adrenalin. These facts suggest that autonomic nervous system may have not an important role in anaphylactic shock, but the antigen-antibody reaction in center and wall of blood-vessel may be the main cause of it. In the sensitized rabbit, no evident change was observed before shock in the reaction to adrenaline and acetylcholine. In the guinea pigs extirpated the left adrenal, anaphylactic shock was provoked as severe as in the guinea pig non-extirepated by the intravenous injection of antigen, but the shock was provoked by the intraperitoneal injection. Schultz-Dale's reaction with the intestine of the sensitized guinea pig adrenalectomized was largely weakened than the reaction in the control.
  • 鈴木 廣造, 新井 義夫
    原稿種別: 本文
    1961 年 10 巻 4 号 p. 253-259,292
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
    Dogs weighing about 10 Kg were sensitized with house serum and shocked. The change of Bradykinin and SRS-A in the blood-plasma during anaphylaxis were quantitatively determined. Bradykinin was extracted and determined following to Baraldo's method and SRS-A was determined by the method of Brocklehurst. The results show that the parallel relationship could not be observed between the doses of Bradykinin or SRA-A detected during anaphylaxis and symptoms of the shock. These results suggest that these substances may have not a significant role as the shocking agent for producing anaphylaxis. The change of substance-P in the liber and small intestine in the control and shocked guinea pigs were also quantitatively determined; but not a change was observed in the liver, though a slight increase of the amount of substance P was observed in the small intestine. From the results obtained, it might be concluded that Bradykinin, SRS-A and substance-P may have not a significant role in producing anaphylaxis.
  • 萩原 ミサオ
    原稿種別: 本文
    1961 年 10 巻 4 号 p. 260-268,293
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
    Leukotaxin extracted from pleural exudates of rabbits and dogs by the Menkin's method has studied chemically and biologically. 1) The active principle of leukotaxin corresponded to polypeptide I by paper partition chromatography and biological examinations. 2) Polypeptide I was detectalble by the chlorine-iodide-starch procedure (Rydon & Smith method) though the Rf value was relatively variable, and it was negative to ninhydrin reaction and disappeared by acid hydrolysis. The hydrolysate of the substance contained at least six ninhydrin positive substances. 3) Pleural exudates contain several free amino acids beside polypeptide I mentioned above. The species of animals and degree of inflammation had no influence on the constituents of the free amino acids in the pleural exudates. 4) Beside polypeptide I, several factors of fraction C-D extracted by the Menkin's method were found by paper partition chromatography in the area of lower Rf value of the chromatograms, and they had the biological activities of causing dilatation of vessels and edema of tissues.
  • 萩原 ミサオ
    原稿種別: 本文
    1961 年 10 巻 4 号 p. 269-275,293
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
    In order to study on the role of histamine in the development of inflammation, changes of the skin histamine contents in response to antigenic stimulus in the rabbit sensitized with egg albumin were observed. Following the McIntire's method, histamine was extracted from the skin samples and quantitatively determined by the bioassay technique using atropinized guinea pig ileum. The histamine contents of the lateral abdominal skin of the normal rabbit were found 0.5-2.0 μg. per gram of skin tissue. This value was not significantly changed by sensitization. Significant changes were not observed in the skin histamine contents in the early stage of Arthus phenomenon. This fact suggests that the skin histamine does not play and important role in the development of inflammation.
  • 北原 静夫, 川上 岩雄, 小林 修
    原稿種別: 本文
    1961 年 10 巻 4 号 p. 276-284,293-29
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
    In view the large number of antihistamine preparations already presented. introduction of an antihistamine agent can only be justified when it shown that the new comer has a definite therapeutic advance. Allercur, one of the imidazold derivatives, is recommended to be superior in comparison with many other antihistamine preparations. One of my colleague Kawakami synthesized a new type of imidazole derivatives, 4, 5-Diphenylimidazole (DIT). In biological experiments DIT revealed a potent antihistamine, antiacetylcholine and a slight vasodilating activity. Toxicologic studies in mice indicate this compound is considered as quite safe for clinical application. As a clinical experiment, DIT was applied to the eczemetous patients locally in 0.2% concenration in a hydrophil vaselin base. Therapeutic results were excellent in 10 patients suffering from acute eczematous dermatitis, moderate in 17 patients, with chronic eczema. No effect was noticed in 8 cases. Topical therapy with antihistamine becomes often irritain, but as far as DIT there is no such fear. DIT was administered to 25 patients with urticaria in dosages of 5-10 mg three times daily after meals. Good to excellent results were achieved in 15, but in 10 cases the response was poor, particularly in chronic patients. Side effects were very few. Gastrointestinal upset was encountered in only one. DIT is a safe, effective antihistaminic agent with a very low incidence of such side effects as drowsiness, dryness of the mouth, which have been described with previous antihistaminic agents.
  • 深井 登起子
    原稿種別: 本文
    1961 年 10 巻 4 号 p. 285-288,294
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
    For the purpose of clarifying the process of natural sensitization by intestinal flora, somatic antigen of E. coli were rectally given to guinea pigs and rabbits. Agglutination reaction, Arthus phenomenon and Schultz-Dale reaction were also tested for demonstrating the rectal sensitization. Agglutination test with E. Coli was conspicuously observed to be positive in all of 28 rectally sensitized adult rabdits; the titer was 10-160 X at the pre-sentsitization, but it showed 80-5, 120 X after the sensitization. The rise of the agglutinin titer was also seen in 9 out of 23 young rabbits sensitized in the same procedure; after the sensitization the agglutinin titer was elevated to 20 X in 3 cases. to 40 X in 1, to 160 X in 2, 320 X in 1, to 640 X in 1 and to 1280 X in 1, though the initial titer of them were only 10 X. Furthermore, the facts were observed in some of rectally sensitized guinea pigs. In the rabbits sensitized rectally and orally, the higher hemagglutination titer was demonstrated in the former with smaller doses, only with 1/3-1/10 of those in the latter. Skin test was performed on rectally sensitized rabbits and guinea pigs, and some of them were proved to be positive in Arthus phenomenon. Schultz-Dale reaction was also positive in some of rectally sensitized guinea pigs. In this case the difficulty of the desensitization seemed to be characteristic. To summarize, when E. coil antigen was given to the guinea pigs and rabbits, agglutinin titer being elevated, positive Arthus phenomenon and Schultz-Dale reaction were demonstrated. These facts suggest that the intestinal sensitization by bacterial antigen was considered to be an important route in natural sensitization by E. coli.
  • 松尾 肅
    原稿種別: 本文
    1961 年 10 巻 4 号 p. 289-291,294
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
    Salve containing 0.2% of diphenylimidazole was locally applied on 24 cases of eczema, dermatitis and other itchy skin diseases, and it was found to be effective in 18 cases for itching and for improvement of eruption in 14 cases. If the concentration and base ointment of DIT are to be closely examined, it is believed that its limit of appliance and effect would be further increased.
  • 原稿種別: 文献目録等
    1961 年 10 巻 4 号 p. 292-294
    発行日: 1961/04/30
    公開日: 2016/10/20
    ジャーナル フリー
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