アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
10 巻, 5 号
選択された号の論文の7件中1~7を表示しています
  • 原稿種別: 目次
    1961 年 10 巻 5 号 p. 1-4
    発行日: 1961/05/30
    公開日: 2016/10/20
    ジャーナル フリー
  • 深井 登起子
    原稿種別: 本文
    1961 年 10 巻 5 号 p. 297-306,337
    発行日: 1961/05/30
    公開日: 2016/10/20
    ジャーナル フリー
    To elucidate what role the cross allergic reaction plays in the pathogenesis of dysentery and enteritis on the basis of sensitization by Escherichia coli, rabbits rectally sensitized with E. coli 0-13 and untreated were inoculated by De and Chatterije's method in their isolated loops of intestine with E. coli 0-13 or Shigella flexneri 2b, which has an antigen in common with the former, and the development of enteritis was observed both macroscopically and microscopically. Seven out of 11 E. coli-sensitized rabbits developed enteritis in the small and large intestine after the inoculation of E. coli. After the inoculation of Sh. flex., enteritis developed in the large and small intestine in 7 cases out of 13 sensitized animals. On the other hand, the inoculation of E. coli induced enteritis in the small intestine of 3 and in the large intestine of 4 of 13 control rabbits, and that of Sh. fiex. in the small intestine of 3 and in the large intestine of 1 of 12 controls. Enteritis induced by E. coli and Sh. flex. resembled each other both macroscopically and microscopically. Histologically necrotic fibrinous hemorrhagic enteritis was observed, and the finding is similar to that in human dysentery. These results seem to clarify the relationship between E. coli sensitization and development of dysentery and enteritis, indicating the participation of allergic factor in their pathogenesis.
  • 石崎 達, 荒木 英斉, 久津見 晴彦
    原稿種別: 本文
    1961 年 10 巻 5 号 p. 307-317,337-33
    発行日: 1961/05/30
    公開日: 2016/10/20
    ジャーナル フリー
    This study was designed to evaluate the specificity of the skin reactions induced by intradermal injections of various antigens. The intradermal skin tests were carried out with the crude extracts of hookworm, house dust and ragweed in 118 and 484 individuals in the rural districts of Tokyo and Shizuoka Prefecture. These antigens were extracted with D. P. solution and diluted with physiological saline. The dilution of the injected were 1:10,000 in hookworm, 1:1,000 in house dust, and 1:1,000 in ragweed. As the control, physiological saline and a 1:10,000,000 solution of histamine hydrochloride diluted with physiological saline were used. One twentieth ml. of each solution was injected in the flexor surface of forearms. All measured reactions were of immediate type, 15-20 minutes after injections. Each wheal and erythema was measured in two directions (paralleled to arm length and transverse of it), and the average of two readings was described as the diameter of the wheal and erythema. 1) The distribution of the diameter of wheal produced by the physiological saline in 222 individuals showed a normal distribution and their mean and standard deviation were 6.4±1.38 mm. The distribution of erythema showed likely logarithmic one. 2) Each of these three antigens showed two similar peaks in the distribution curves of the wheal and erythema. The first peak in the smaller diameter side resembled that caused by the physiological saline concerning both wheal and erythema. The second peak in the larger diameter side corresponded to the group which was sensitized by specific antigens. Concerning hookworm infection and the growth of ragweed, there were more chances of antigen contact in the district of Tokyo than that of Shizuoka Prefecture. Comparison with the result of the each district revealed that the second peaks of the distribution curves both in wheal and erythema were significantly higher in the former district. 3) The three antigens tested in the same population showed the similar distribution curves of the diameters of wheal and erythema with the two peaks, and with the minimal points between the two peaks situated in the same part. From these results it seemed reasonable that the boderline diameters between negative and positive reactions be set at the same point; 9 mm in wheal and 20 mm in erythema. When these standard were apllied to the reactions of hookworm patients, more than 90% of them were included in the range of positive reaction. 4) When the measurement was done only on the reaction caused by antigen, the false positive reaction might occur in hypersensitive persons to some unspecific irritants. So that, the diameters of antigen reactions both in wheal and erythema were compared with the differences of diameters between the antigen and saline reactions, and the correlation coefficients between those measurement were+0.8〜+0.9 in wheal and+0.96〜+0.99 in erythema concerning three antigens respectively. Negative reactions to antigens were mostly same to the saline reactions both in wheal and erythema (over 70% of them). 5) Wheal reaction was not always proportional to the erythema, though a high correlation (r=+0.7) was observed between them. Then it may be rational that the positive response must be judged by the simultaneous measurement of wheal and erythema. 6) A slight correlation was observed between the diameters of wheal and/or erythema of three antigens and those of histamine (r=+0.35).
  • 入江 輝夫
    原稿種別: 本文
    1961 年 10 巻 5 号 p. 318-331,338
    発行日: 1961/05/30
    公開日: 2016/10/20
    ジャーナル フリー
    The experiment was carried out on the intravascular antigen-antibody reaction induced by injecting the anti-rabbit thrombocyte guinea pig serum into the marginal ear vein of rabbit. Rabbits were autopsied from two hours to thirty days after the provocative injection, and the hematological changes and the histological changes of the lung and heart was examined periodically. The results indicate that thrombocyte count decreased remarkably one or two hours after the provocative injection, and then it was recovered gradually to normal level. Microscopicopically, the hemorrhagic necrotic foci of the lung was observed and the pulmonary vessels revealed cardinal pathological changes such as marked proliferation of the arterial endothelial cells and numerous thrombosis. The hemorrhage, necrosis and proliferation of connective tissues were also revealed in the heart.
  • 三島 健, 村野 順三
    原稿種別: 本文
    1961 年 10 巻 5 号 p. 332-336,339
    発行日: 1961/05/30
    公開日: 2016/10/20
    ジャーナル フリー
    A 9 years and 1 month old girl having a fitful headache was proved to be hypersensitive to house dust and peanuts by scratch test and skin reaction. This hypersensitivity was also demonstrated by Prausnitz-Kustuer test and elimination diet. These symptoms were improved by means of hyposensitization with house dust solution and elimination of peanuts.
  • 原稿種別: 文献目録等
    1961 年 10 巻 5 号 p. 337-339
    発行日: 1961/05/30
    公開日: 2016/10/20
    ジャーナル フリー
  • 原稿種別: 付録等
    1961 年 10 巻 5 号 p. App3-
    発行日: 1961/05/30
    公開日: 2016/10/20
    ジャーナル フリー
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