アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
10 巻, 9 号
選択された号の論文の7件中1~7を表示しています
  • 原稿種別: 目次
    1961 年 10 巻 9 号 p. 1-4
    発行日: 1961/09/30
    公開日: 2016/10/20
    ジャーナル フリー
  • 水川 孝, 三村 康男
    原稿種別: 本文
    1961 年 10 巻 9 号 p. 483-503
    発行日: 1961/09/30
    公開日: 2016/10/20
    ジャーナル フリー
  • 春名 英彦
    原稿種別: 本文
    1961 年 10 巻 9 号 p. 504-508,546
    発行日: 1961/09/30
    公開日: 2016/10/20
    ジャーナル フリー
    A series of experiments were carried out on the serotonin metabolism in children with bronchial asthma. I The serum serotonin level ranged from 0.18 to 0.03 mcg/ml (mean value: 0.10) in 26 asthmatic cases during the interval stage, from 0.18 to 0.09 mcg/ml(mean value: 0.13) in 12 asthmatic cases during the wheezing stage, and from 0.25 to 0.13 mcg/ml (mean value: 0.21) in 15 asthmatic cases during the attack stage, showing a tendency of elevating level in comparison to the normal value of healthy children. This indicates that the serotonin level is directly related to the clinical picture of bronchial asthma. In 17 cases, concomitantly with the disappearance of symptom following administration of prednisolone, the value was restored to the normal level, being from 0.09 to 0.03 mcg/ml (mean value: 0.06), but in the 4 cases still wheezing the level was 0.13-0.10 mcg/ml. A highly significant difference was noted among three stages. The administration of adrenalin and amino-phylline did not bring about a constant change in the serum serotonin level. II The urinary 5-HIAA excretion level ranged from 1.04 to 2.84 to 2.84 mg/day (mean value: 1.94) in 24 samples collected from 5 asthmatic cases during the interval stage, and from 1.26 to 2.71 mg/day (mean value: 2.22) in 8 samples collected from 2 asthmatic cases during the wheezing stage. The excretion level of all of these cases was normal. The level ranged form 0.70 to 2.87 mg/day(mean value 124) in 9 samples collected from 4 asthmatic cases during the attack stage. Apart from the one exceptional case, however, the level showed a decreasing tendency, being 0.70-1.39 mg/day. By treatment with prednisolone during the attack stage, the mean value on the first and second day was 1.66 and 1.55 mg/day respectively, but the 5-HIAA level suddenly increased from the third day and thereafter, the averaging 3.00-3.72 mg/day or twice that during the attack stage. There were highly significant differences in the value among the following stages, i.e the interval stage, wheezing stage, attack stage and later term of therapy stage. No relation between the steroid administration dose and the urinary 5-HIAA excretion level was demonstrated. Unlike children with Ekiri-like syndrome, a slight disturbance of the serotonin metabolism was always noted in children with bronchial asthma. This signifies that the monoamine oxidase activity in these children is lower than that of healthy children, resulting in difficulty to transform the increased serotonin to 5-HIAA. Steroids, by accelerating the monoamine oxidase activity in man as well as in amimals, increase the removal of serotonin and thus correct the disturbance in the serotonin metabolism. This provides one of the pharmacological basis for using steroids in the treatment of asthmatic attacks.
  • 津田 孝憲
    原稿種別: 本文
    1961 年 10 巻 9 号 p. 509-531,547
    発行日: 1961/09/30
    公開日: 2016/10/20
    ジャーナル フリー
    In relation to the systemic necrotizing angitis due to the "collagen diesase", a series of experiments were carried out to clarify the pathogenetic mechanism of the allergic angitis induced by the active anaphylaxis in rabbit sensitized with the human and bovine serum gamma globulin. Based upon the Hamamoto's theory of "Intravascular Antigen-Antibody Reaction", these heterologous serum gamma globulins were injected intravenously through the marginal ear veins into rabbits whose serum titer against these serum gamma globulins were sufficiently high. Rabbits were sacrificed from one day to fifteen days after the provocative injection, and then the pathohistological changes of the lung and the heart were examined. At the same time, in the course of each experiment, hematological changes of the peripheral blood and electrophoretic changes of the serum protein were observed. Major pathohistological changes were those of vessels in the lung. The changes were as follows; (1) proliferation and degeneration of the endothelial cells of arteries, occasionally showing some granulomatous formation, and intense edema in the subendothelial area, (2) productive endarteritis mainly in the muscular arteries, sometimes accompanied by the formation of granulomatous plugs. (3) stricture or obstruction of the arteries and thrombi in the arteries as the results of the endothelial changes described above, (4) necrotizing arteritis of the muscular arteries chiefly attributable to fibrinoid necrosis of tunica media. Occasionally dramatic necrotizing panarteritis including the necrosis of both innercoat and tunica media. (5) fibrinoid necrosis of arteriolar walls, (6) perivascular infiltration of pseudo-eosinophile leucocytes, (7) productive endophlebbitis in small veins. These arterial changes were most remarkable in the period between two days and five days after the provocative injection. In addition to the vascular changes mentioned above, the septal inflammation(interalveolitis) without any inflammation nor exsudation in the alveolar cavities was observed in the lung and the nodular proliferation of alveolar epithelial cells remained prominent fifteen days after the provocative injection. The histological changes in the heart were as follows; (1) slight arterial changes in comparison with those in the lung, (2) foci of vacuolar and waxy degeneration and of waxy necrosis in the myocardium, (3) stasis and small hemorrhage in the myocardium, (4) slight fibrinoid swelling of the endocardium. Then, the hematologic and electrophoretic changes were as follows; (1) intense anemia, (2) remarkable fluctuation in the number of circulating leucocytes, showing leucocytosis five days after the provocative injection, (3) dramatic changes of the total serum protein, (4) hypergammaglobulinemia from two hours to about two days after the provocative injection, and hyperalbuminemia with hyperproteinemia following five days after the provocative injection. These pathohistological changes, especially the arterial changes in the lung, resembled the pattern of "collagen disease" to which belong systemic lupus erythematosus or periarteritis (or polyarteritis) where the typical pathohistological changes of arteries are found, These observation indicated that the pathogenesis of the diffuse systemic necrotizing angitis of collagen disease may be of "allergic" mechanism.
  • 入江 輝夫
    原稿種別: 本文
    1961 年 10 巻 9 号 p. 532-541,548
    発行日: 1961/09/30
    公開日: 2016/10/20
    ジャーナル フリー
    An experiment was made on the intravascular antigen-antibody reaction of thrombocytes. Rabbits were sensitized with normal dog platelets and the provocative injection was administered into the marginal ear vein with dog platelets. Rabbits were autopsied from twenty-four hours to two weeks after the provocative injection and the histological changes of the lung and heart were examined periodically. The results were as follows: In the heart, the slight hemorrhage, myocard degeneration and necrosis were revealed. In the lung, the pulmonary vessels revealed cardinal pathological changes such as marked proliferation of the arterial endothelial cells, the edema beneath the endothelium, periarterial edema and numerous thrombosis in the capillaries and arterioles. In addition megakaryocytes were found in the alveolar wall.
  • 三島 健, 村野 順三
    原稿種別: 本文
    1961 年 10 巻 9 号 p. 542-545,548
    発行日: 1961/09/30
    公開日: 2016/10/20
    ジャーナル フリー
    Three infants with atopic dermatitis sensitive to cow's milk were treated with soybean milk. This soybean milk was produced in Japan for the first time in order to treat the patients with allergic disorders. The diagnosis of these three babies with atopic dermatitis were made by the aide of the precise history, scratch test, and Prausnits-kustner test. When the cow's milk and the foods containing milk were eliminated, the skin lesions of all three cases cleared up and vice versa. It may be the first report concerning soybean milk used for the patient with atopic dermatitis. sensitive to cow's milk. This soybean milk was manufactured by WAKODO.CO.L.T.D.
  • 原稿種別: 文献目録等
    1961 年 10 巻 9 号 p. 546-548
    発行日: 1961/09/30
    公開日: 2016/10/20
    ジャーナル フリー
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