アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
11 巻, 1 号
選択された号の論文の7件中1~7を表示しています
  • 原稿種別: 目次
    1962 年 11 巻 1 号 p. 419-420
    発行日: 1962/01/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 大高 裕一, 藤巻 茂夫, 野口 義圀
    原稿種別: 本文
    1962 年 11 巻 1 号 p. 1-27
    発行日: 1962/01/30
    公開日: 2017/02/10
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  • 渡辺 喜久雄
    原稿種別: 本文
    1962 年 11 巻 1 号 p. 28-40,66
    発行日: 1962/01/30
    公開日: 2017/02/10
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    The Author studied the immunological relationship between cryoglobulin, normal gamma globulin and myeloma globulin. Two cases of so-called idiopathic cryoglobulinemia, twelve cases of symptomatic cryoglobulinemia and three cases of myeloma were studied. For the precise studies of antigenic determinants, antisera were prepared by immunization of rabbits with normal gamma globulin, each one serum from idiopathic cryoglobulinemia and symptomatic one and three sera from different myelomas. Cryoglobulins were purified by repeated cooling, precipitation, centrifugation and dissolving in warm saline. Myeloma globulins were fractionated and eluted by use of starch electrophoresis. These materials were lyophilized and stored in refrigerator. Agar diffusion method by Ouchterlony was used for the analysis of immunological cross reaction. The symptomatic cryoglobulins from patients with subacute endocarditis, lupus erythematosus disseminatus and rheumatoid arthritis showed the same feature as normal gamma globulin against the anti-normal gamma globulin serum by agar diffusion method. By use of an antiserum against a symptomatic cryoglobulin from one patient with subacute endocayditis, normal gamma globulin was found to have the same determinant group to these of this symptomatic cryoglobulin. Cryoglobulin from idiopathic cryoglobulinemia has a cross antigenicity to the normal gamma globulin, further more seems to have much more specific determinant groups other than the normal gamma globulin does have. In three cases of myeloma one of them has the same determinant groups as normal gamma globulin, the other two have a defect in these determinant groups. Whether the specific determinant groups in idiopathic cryoglobulinemia are of a common property in this disease or different in individual case, remained to be studied. It would appear that these abnormal serum proteins even with the same physico-chemical properties by electrophoresis and ultracentrifugation can be differentiated and classified by immunological method. Cryoglobulin from a patient with idiopathic nature which has specific determinant groups other than those of normal gamma globulin can be determined quantitatively by the vertical agar diffusion method by Oudin with satisfactory results.
  • 村中 正治, 北村 芳太郎, 西沢 一郎, 山本 恵一郎, 吉田 赳夫
    原稿種別: 本文
    1962 年 11 巻 1 号 p. 41-51,66-67
    発行日: 1962/01/30
    公開日: 2017/02/10
    ジャーナル フリー
    In the recent years, it has been conceived that thrombocytes play some roles in clinical hypersensitivity. The authors studied on drug hypersensitivity of which "allergen" has a definite chemical structure, e. g. PAS-Na, penicillin and aminopyrin. The thrombocytes number was counted immediately and 2 hours after incubation of anticoagulated blood with estimated antigen. The counting followed Brecher's Method. The ratio of the thrombocytes number after incubation to the inital thrombocytes number was calculated:The results obtained were as follows: 1) Among anticoagulants, Na-oxalate and heparin, especially the former, were most suitable for this test. 2) There was no difference in thrombocyte counts of venous blood between drug hypersensitive patients and normal subjects. 3) There was no significant decrease of thrombocytes number in oxalated blood of normal subjects after incubation with small amount of penicillin, aminopyrin or PAS-Na.
  • 村中 正治, 北村 芳太郎, 菊谷 豊彦, 吉田 赳夫
    原稿種別: 本文
    1962 年 11 巻 1 号 p. 52-65,67
    発行日: 1962/01/30
    公開日: 2017/02/10
    ジャーナル フリー
    The in vitro changes in number of thrombocytes of various blood was studied in drug hypersensitive patients as it was thought to be one of the subsequenting phenomena of in vitro antigen antibody reaction. Forty-six cases with drug hypersensitivity 14 cases of penicillin-hypersensitivity, 16 cases of aminopyrin-hypersensitivity and 16 cases of PAS-hypersensivity and 40 non-sensitive cases as control were tested. One drop of the diluted drug was added to 2, 5 ml of oxalated blood and incubated at 37°C. The number of thrombocytes was counted at 0 time, 30 minutes, 1 hour, and 2 hours, after the mixture of blood antigen. The results obtained were as follows: 1) Decrease in thrombocyte count after the addition of penicillin, aminopyrin, and PAS-Na was within 20% in the control blood. 2) With penicillin-hypersensitive patient's blood, the mean decrease was 36, 2%, with aminopyrin-hypersensitive patient's blood 34, 1% and with PAS-hypersenitive patient's blood 30, 1% respectively, demonstrating the significant difference in comparison with above mentioned control values. 3) Mild agglutination of thrombocyte was occasionally observed during thrombocyte count in the cases of hyper-sensitive, however not a remarkable change was observed in the number of thrombocyte count. These facts suggest that the main cause of this phenomenon may be due to thrombocytolysis. 4) In the hyposensitized case with the desensitization of PAS, this phenomenon could not be observed. From these results the authors emphasize that it is one of the reliable and useful diagnostic methods of drug hypersensitivity.
  • 原稿種別: 文献目録等
    1962 年 11 巻 1 号 p. 66-67
    発行日: 1962/01/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 付録等
    1962 年 11 巻 1 号 p. App1-
    発行日: 1962/01/30
    公開日: 2017/02/10
    ジャーナル フリー
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