アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
11 巻, 7-8 号
(7・8)
選択された号の論文の21件中1~21を表示しています
  • 原稿種別: 表紙
    1962 年 11 巻 7-8 号 p. Cover1-
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 原稿種別: 表紙
    1962 年 11 巻 7-8 号 p. Cover2-
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 原稿種別: 付録等
    1962 年 11 巻 7-8 号 p. App4-
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 石川 光昭, 青木 利彦, 工藤 春一, 並木 宏
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 203-209,261
    発行日: 1962/08/30
    公開日: 2017/02/10
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    Rabbits were sensitized with iodine, potassium iodide, bromine, arsenious acid, nickel sulfate, potassium bichromate or mercuric chloride, and 2 weeks later skin-sensitizing antibodies in the serum were measured with corresponding allergens by the dilution method. To detect the specifity of the difference between the normal serum and the antiserum in the capacity to combine with the 7 chemical allergens, a definite amount of a corresponding antigen or each of the 5 other allergens was added to the serum contained in 7 test tubes. Then the mixture was placed in the cellophane sac, dialyzed against phosphate buffer solution in the ice-box for 5 days, and the chemical substance remaining in the sac was determined by a colorimetric method. The results disclosed that the anti-iodine, anti-bromine, anti-arsenious-acid, anti-potassium-bichromate and anti-mercuric-chloride serums showing high titers of antibodies exhibited specifity of the difference in the combining capacity, i.e., a tendency was noted that a stronger combining ability of an antiserum was definitely shown only with its corresponding allergen. But the anti-potassium-iodide and anti-nickel-sulfate serums that showed comparatively low titers of antibodies failed to indicate such specifity.
  • 西村 祐一
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 210-224,261-26
    発行日: 1962/08/30
    公開日: 2017/02/10
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    M.Kaku and his associates have demonstrated that the human placental polysaccharide-like substance (KPS) has an antigenicity immunologically and there is an antibody against the substance in the serum of patient with toxemia of pregnancy. Furthermore, the pathological changes similar to the toxemia of pregnancy was experimentally caused in rabbit and dog with KPS substance. The author immunized the rabbits with KPS and with the substance plus adjuvant respectively. After the immunization was completed, both the titer of antibody and the pathological change of liver and kidney in experimental animals following the reinjection of KPS substance were compared. On the other hand, the Glycyrrhizine which may inhibit the antibody formation was given to the rabbit during the immunization of KPS substances and then both the titer of antibody and the change of liver and kidney were observed. The results were as follows: 1) The titer of antibody was higher in the group of KPS plus adjuvant immunization than in that of the KPS immunization alone. When the Glycyrrhizine was given to these groups, the antibody formation was inhibited. 2) The histopathological changes of liver and kidney in the adjuvant group were more severe than the group immunized with KPS alone. The changes were similar to those of toxemia. On the contrary, in the group administrated with Glycyrrlizine the changes of organs were mild. 3) From the experimental observation it was considered that the titer of antibody against placental substance (KPS) has a close relation with the pathological changes in organs of experimental animals. 4) From above mentioned results it may be concluded that the Glycyrrhizine reduces the ability of antibody formation but does not affect the titer of antibody which was priorily formed by the injection of KPS substance.
  • 鳥居 , 木村 , 大島 , 石崎 , 齋藤 , 進藤 , 笹川 , 高橋 , 野口 , 山本 , 松原 , 八倉 , 藤浪 , 松本 , ...
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 225-229
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 木村 義民, 新井 義夫, 高橋 昌己
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 230-234,262
    発行日: 1962/08/30
    公開日: 2017/02/10
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    It is recognized that antihistaminics are not uniformaly effective in any allergic disorder and that some diseases of allergic origin are quite resistant to therapy. The failure of the antihistaminics in such situations has been attributed to the formation or liberation of substances other than histamine which either support or produce effects similar to the latter and which are not influenced by antihistaminics. A substance which is receiving increasing attention as a possible important entity in diseases of hypersensitivity is serotonin. Comparative studies of Diphenylpyraline (Hystamin), Cyproheptadine and LSD (lysergic acid diethylamide) were carried out. The activities related to anti-allergy were investigated. The results obtained were as follows; 1) In the protective activities of the drugs against edema produced by local injection of serotonin or egg-white in rats, Cyproheptadine was found to be so effective to edema produced by serotonin but Diphenylpyraline was also found to be comparatively effective. 2) It was shown that the pretreatment of Cyproheptadine or LSD is so protective against the lethal effect of serotonin in B. pertussis treated mice and Diphenylpyraline have slight effective activity. 3) It was shown that the pretreatment of Diphenylpyraline completely protected against the death by anaphylactic shock and Cyproheptadine or LSD have also protective effect against anaphylactic shock. 4) In vitro activities of the anti-allergy drugs against the contraction of the isolated guinea pig intestine induced by histamine, acetylcholine, serotonin, barium chloride and anaphylaxis were studied. The results show that Cyproheptadine is superior in anti-serotonin activity than that of Diphenylpyraline and Diphenylpyraline is superior in antihistamine and anti-barium chloride activity than that of Cyproheptadine.
  • 矢村 卓三
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 235-
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 川村 太郎, 笹川 正二, 木下 正子
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 236-237
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 樋口 謙太郎, 松村 武正
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 238-242,262-26
    発行日: 1962/08/30
    公開日: 2017/02/10
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    Statistical observations on 67 patients in the author's clinic from June to December 1961 were carried out. The results obtained were as follows; Clinical form: 50 cases of urticaria acuta, 5 cases of Urticaria chronica, 6 cases of Urticaria with temperature and one is the other type of Urticaria. Sex and age: Female exceeds male in number. As for the age, the 10-30 years old was most numerous. Seasonal frequency: It is most frequent in summer, next in autumn, then spring and winter. Further observations were carried out on the ethiology, symptom and some clinical examinations. As the skin-test 0.02 ml of the extracts were injected into the inner side of the forearms and examined the diameter of the papules and redness 15 minutes after injection. The patients showed positive response by the extracts sf hausedust, shellfish and meat in the highest rate.
  • 藤浪 得二
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 243-
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 244-
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 野口 義圀, 永井 隆吉, 平井 義雄
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 245-
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 熊谷 朗, 鈴木 恵子, 八倉 隆保, 七星 正久
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 246-251,264
    発行日: 1962/08/30
    公開日: 2017/02/10
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    Skin test with various allergenic extracts is one of the tests of diagnostic value for allergic diseases. But as we have no precise standard of this test concerning with the concentration, specificity of allergenic extracts and normal skin reactivity, we the authors tried to establish proper criteria of positive or negative test based on statistical examinations. In this study skin reactivities of normal persons free from allergic diseases were tested for following allergenic extracts. 1) Physiological saline 2) Histamine ×10^<-6> 3) Acetylcholine ×10^<-3> 4) House dust (No.110) ×10^<-3> ……Total N=0.90γ/ml Trot. N=0.17 5) Ragweed pollen (No.2) ×10^<-3> ……Total N=7.93 Prot. N=4.51 6) Lobster ×10^<-3> ……Total N=4.13 Prot. N=0.66 7) Fishes (mixture of mackerel, bonitor, saurel & sardine) ×10^<-3> 8) Egg (whole) ×10^<-3> Skin erythema and wheal were measured in size 15 min. after intradermal injection of 0.02 ml. of rllersens. In conclusion, as the intensity of the allergenic skin reactivity varies with the sorts of the allergens used, the concentration of allergens should be determined based either on normal skin reactivity for each allerfens, or on definite intensity of skin reactions for all allergens. And specificity of skin test for specific allergen sheuld be evaluated in relations to control skin reactivities to physiological saline and histamine or acetylcholine.
  • 高橋 昭三, 高島 盛輝, 豊泉 忠, 川上 保雄
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 252-254,263-26
    発行日: 1962/08/30
    公開日: 2017/02/10
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    Clinical surveys were carried out on 26 patients with urticaria: acute type, 9; chronic type, 17. In cases of the acute type was no sex difference, but incidence of cases of the chronic type was remarkably higher in the females than in the males. Incidences of cases with a positive family history of atopic diseases were higher in the chronic type than in the acute type. The main provocative causes were foods in both types, but physical stress was also an important causative factor in the chronic type. The laboratory examinations showed: the urine negative in all cases; eosinophilia in 2 out of 10 in the chronic type: stools positive for the ova of ascaris in one out of 11 cases: cases; abnormalities of BSP, CCF, and TTT test in 14.3%, 23%, and 18% of chronic type, respectively. Incidences of positive skin reactions to miscellaneous allergenic extracts prepared by the Torii Pharmaceutical Co. were in 11.5 to 75% of the acute type (highest incidences in the case of mat and tomato extracts) and in 7.7 to 71.4% of the chronic type (highest incidences in the case of tomato and lobster extracts).
  • 斉藤 泰弘
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 255-258,264-26
    発行日: 1962/08/30
    公開日: 2017/02/10
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    In order to reveal the roentgenological changes of the small intestine of allergic patients, following studies were carried out. After ingestion of 300 cc of barium meal serial exposures were carried out every 15 minutes until one hour and then every 30 minutes up to 4 1/2 hours to take the indirect X-ray photogram (6×6 cm in size). Occasionally fluoroscopic examination and direct photography were also combined. The difference between the examination with and without allergenic food was studied. The results were summarized as follows; 1) Even with simple barium meal the patients of alimental urticaria and of diarrhea due to particular food showed delayed empting of the stomach and shortened transit time of the small intestine. In asthmatic patients these values remained with in the normal limit. The intestinal mucosal pattern disclosed no abnormality in majority of these cases. 2) Provocation was performed by the ingestion of allergenic food mixed with barium meal in the groups of urticaria and allergic diarrhea, and by the inhalation of acetylcholine solution in asthmatic patients. By the provocation, a) In almost all of these allergic patients, the stomach empting time was delayed, and the time in which the first half dose of barium was excreted from the stomach was especially prolonged. Extremelly shortened transit time of the small intestine was observed in the patients of allergic diarrhea. b) In asthmatic patients the roentgenological findings of the small intestine showed no remarkable changes. Both in urticaria and diarrhea groups, hyperkinesis and flocculation in the small intestine were observed. c) These roentgenological changes in the small intestine were not presented in the healthy control group, although the same allergenic foods were given. 3) In one case of urticaria biopsy of the small intestine showed wheal formation and cell infiltration of the intestinal wall.
  • 大島 良雄, 石崎 達, 竹田 浩洋
    原稿種別: 本文
    1962 年 11 巻 7-8 号 p. 259-260,265
    発行日: 1962/08/30
    公開日: 2017/02/10
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    Population of three districts and outpatients having urticaria visited the authors clinic were used. Rate of the patients with urticaria in the history is about 12 per cent in farming districts and about 20 per cent in a coastal district. However, one tenth of those person were developed to chronic status. Result from out-patients show that onset of urticaria was accumulated in April and May and outbreak of rash in a day was also accumulated in the evening. Causes of onset are such as: food (32%), cold or warm stimulus (10% each), press (10%) and unknown (20%) respectively. In food, fishes are main causes of urticaria in Japan. Pasitive rates of intracutaneous test in patients were 40% of crab, 25% of Bamboo root, 30% of spinach, 42% of tomato and 20% of beef (all allergen: 10^<-3> dilution, 0.02 ml). Sites of outbreak of urticaria were more frequently on eztremities them on body. In routine tests for patients, urobilinogen in urine and B.S.P. test of liver were more frequently positive than usual. However, eosinophilic cell count (%) in blood was mostly between normal range
  • 原稿種別: 文献目録等
    1962 年 11 巻 7-8 号 p. 261-265
    発行日: 1962/08/30
    公開日: 2017/02/10
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  • 原稿種別: 付録等
    1962 年 11 巻 7-8 号 p. App5-
    発行日: 1962/08/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 表紙
    1962 年 11 巻 7-8 号 p. Cover3-
    発行日: 1962/08/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 表紙
    1962 年 11 巻 7-8 号 p. Cover4-
    発行日: 1962/08/30
    公開日: 2017/02/10
    ジャーナル フリー
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