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Article type: Index
1964 Volume 13 Issue 10 Pages
799-803
Published: October 30, 1964
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Article type: Bibliography
1964 Volume 13 Issue 10 Pages
Misc2-
Published: October 30, 1964
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Tatsushi Ishizaki, Hidenari Araki, Terumasa Miyamoto, seiki Otsuka, So ...
Article type: Article
1964 Volume 13 Issue 10 Pages
647-654,702
Published: October 30, 1964
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Patients of bronchial asthma, 47 cases in total, were followed up clinically during six months since their first day of visit to our clinic as out-patients. Asthma diary was designed and prepared for the purpose of checking symptoms every day by patients themselves. Patients were also tested on routine clinical examinations including skin tests, provocation tests by allergen and achetylcholine inhalation test. 1.There are three types of asthmatic attacks with regard to the onset and the course: the major type shows a symptom complex consisted of severely developing attacks within several days and symptoms suggesting of bronchial infection, the chronic type has attacks followed by continuous wheezing of several days, and the periodic type shows an attack occurring at a fixed time in a day without following wheezing afterward. 2.These three types of attack could apear alternately in the same patient during six months observed. But a certain patient had a predominant type of attacks through whole period of observation. Patients of nasal type(asthma attacks with rhinorrhea) suffered more likely from periodical attacks in the morning, and patients of bronchial type from chronic attacks. 3.Headache, sneeze, perspiration and palpitation were seen more frequently in asthma attack among patients of nasal type. 4.Coincidence rate of rhinorrhea with asthma attack is related positively to the size of skin reaction by house dust antigen and higher bronchial sensitivity to acetylcholine test. Patients positive to provocation test by house dust antigen reacted also positive to skin test and showed higher incidence of asthma attack with rhinorrhea.
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Yoshitaka Miyanaga
Article type: Article
1964 Volume 13 Issue 10 Pages
655-660,702-70
Published: October 30, 1964
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Hitherto histamine, serotonin and acetylcholine have been the chemical mediators in allergic and anaphylactic reactions. From these points of view many anti-a llergy drugs have been synthesized. However, as the author described in the 1st report, bradykinin might be one of chemical mediators in allergic or inflammatory reactions. On the other hand, only aspirin and phenylbutazone have been reported as antibradykinin drugs and few works have been done on anti-bradykinin drugs. Recently Homochlorcyclidine(SA-97) was synthesized by Abbott Laboratory as anti-allergy drug having anti-bradykinin activity. The author studied on the anti-allergic and anti-bradykinin activities of many kinds of anti-allergy drugs and the following results were obtained. 1)The pretreatment of SA-97(Homochlorcyclidine) at the concentration of 0.52mg/kg showed 80% protective effect against anaphylactic shock in the guinea pig. 2)Anti-bradykinin activities of 12 kinds of anti-allergy drugs were tested in vitro by Schutz-Dale technique. The intestinal contraction by 0.1mcg/ml of bradykinin was completely inhibited by SA-97 at the concentration as low as 0.1mcg/ml. Among the tested anti-allergy drugs, SA-97, diphenylpyraline and cyproheptadine have powerful anti-bradykinin activities. 3)It was demonstrated that these three anti-allergy drugs have anti-histamine, anti-serotonin, and anti-acetylcholine activities as well as anti-bradykinin activity and also anti-anaphylactic acti-vity. It was also found that anti-allergy drugs other than these drugs such as pyribenzamine have only slight anti-bradykinin activity.
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
661-664
Published: October 30, 1964
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[in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
664-668
Published: October 30, 1964
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1964 Volume 13 Issue 10 Pages
669-672
Published: October 30, 1964
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1964 Volume 13 Issue 10 Pages
672-677
Published: October 30, 1964
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[in Japanese], [in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
677-679
Published: October 30, 1964
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
679-681
Published: October 30, 1964
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[in Japanese], [in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
681-682
Published: October 30, 1964
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
683-684
Published: October 30, 1964
Released on J-STAGE: February 10, 2017
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[in Japanese], [in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
685-
Published: October 30, 1964
Released on J-STAGE: February 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1964 Volume 13 Issue 10 Pages
686-689
Published: October 30, 1964
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[in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
689-693
Published: October 30, 1964
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[in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
693-695
Published: October 30, 1964
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[in Japanese], [in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
695-696
Published: October 30, 1964
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1964 Volume 13 Issue 10 Pages
697-700
Published: October 30, 1964
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[in Japanese]
Article type: Article
1964 Volume 13 Issue 10 Pages
700-701
Published: October 30, 1964
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Article type: Bibliography
1964 Volume 13 Issue 10 Pages
702-703
Published: October 30, 1964
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Article type: Appendix
1964 Volume 13 Issue 10 Pages
App2-
Published: October 30, 1964
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