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Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
14 巻, 12 号
選択された号の論文の18件中1~18を表示しています
  • 原稿種別: 表紙
    1965 年 14 巻 12 号 p. Cover5-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 原稿種別: 表紙
    1965 年 14 巻 12 号 p. Cover6-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 原稿種別: 付録等
    1965 年 14 巻 12 号 p. App5-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 長沢 俊彦, 成清 卓二, 柴田 整一
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 651-657,712
    発行日: 1965/12/30
    公開日: 2017/02/10
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    In a previous paper it was shown with fluorescent antibody technic that nephrotoxin (anti-rat kidney immune rabbit sera), which is injected intravenously to a normal rat, lacalizes selectively in the glomerular basement membrane. In this report an experiment was designed to make nephrotoxin pass through glomerular basement membrane into tubular lumen to see if nephrotoxin reacts with tubular cytoplasm and its basement membrane. For this purpose nephrotoxin was injected to an aminonucleoside nephrotic rat and its kidney was subjected to the fluorescent staining with anti-rabbit-γ-globulin. Specific fluorescence were detected not only in glomerular basement membrane, but also in Bowman's urinary space and tubular lumen. But there were no specific fluorescence in tubular cytoplasm and its besement membrane. These results might give a clue to the problems concerning the common antigenicity between glomerular and tubular basement membrane, and other relating matters. In addition the distribution and intensity of rat-γ-globulin in gromeruli of aminonucleoside nephrosis were studied in this experiment to investigate whether autoimmune process concerns in the progress of this experimental nephrosis or not. The fluorescent staining with anti-rat-γ-globuin showed almost equal findings as a normal rat glomeruli and so-called "mesangial patterns" designated by Unanue & Dixon were not found in our experiment.
  • 宮下 晴夫
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 658-665,712-71
    発行日: 1965/12/30
    公開日: 2017/02/10
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    The pattern of tuberculin reaction is altered at the site of previous tests. At a previously used site, reaction appears earlier and fades sooner than at a new site. In order to ascertain whether this change of reactivity of the tested skin area is the result of local sensitization by injected tuberculin, or it is merely the nonspecific consequence of local inflammation, two experiments were performed. In the first experiment, 0.06 mcg of PPDs, 10 u of agglutinogen of. B. pertussis and 15 u of "Communin" (a filtrate of culture medium of E. coli) were injected in three new sites respectively on the backs of eight adults. Every two weeks each of these antigens was injected twice or three times in the same site. One month after the last injection PPDs was injected in all three sites and in a new site as a control. Reactions were observed 4, 8, 24 and 48 hours after injection. As the site where PPDs was repeatedly injected, remarkable early reaction and typical accerelation of the delayed reaction observed in all cases. where agglutinogen or "Communin" had previously been injected, the typical alteration of reaction pattern with early reaction and accelerated delayed reaction were not noticed except in one case, though the reaction was intensified in other cases. In the remaining four cases reaction pattern was the same as at the new site. In summary, other antigens injected intradermally could not influence the subsequent tuberculin reaction in the same manner as tuberculin itself. In the second experiment, previous injections were the same as in the first. One month after the last injection agglutinogen was injected in all three sites and in a new site as a control. The observation times were the same in the first. At the site where agglutinogen was repeatedly injected, early reaction and acceleration of delayed reaction were observed in all cases. At the sites where PPDs of "Communin" had previously been injected, reaction pattern was almost the same as at the new site. In summary, in other delayed type skin reaction such as agglutinogen skin test, the same alteration reaction pattern at the repeatedly injected site as in the tuberculin reaction was observe. From the above it became clear that local inflammations elicited by other antigens can not produce the typical modification of reactivity to tuberculin. The acceleration of tuberculin reaction was only observed where tuberculin was previously injected. Similar acceleration by repeated injection can be seen not only with tuberculin but also with other antigen such as agglutinogen of B. pertussis.
  • 宮下 晴夫
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 666-674,713-71
    発行日: 1965/12/30
    公開日: 2017/02/10
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    Report 14 informed that local inflammations elicited by other antigens can not produce the typical modification of reactivity to tuberculin. In the present experiments, the influence of repeated tuberculin injections on the tuberculin negative site was investigated. 1) Influence of tuberculin injection on the subsequent tuberculin reaction at the same site in the tuberculin non-sensitive persons: Five infants, who had never received B. C. G. inoculation and in whom tuberculin reaction was negative, were injected with tuberculin in the new site of the right forearm and with a control solution (diluted Sauton's culture medium) in the corresponding new site of the left forearm. Every two weeks these two materials were injected in the same site five times respectively. In one infant a pallid erytheme with slight induration was observed after 8 to 12 hours at the fourth and fifth injection, buy no typical early reaction was observed in any of the infants. Thereafter, 0.04mg of B. C. G. was inoculated in these infants. After one month tuberculin reaction coverted to positive in all infants. Then tuberculin was injected in three sites on the forearms, namely, the two sites where tuberculin or the control solution had previously been injected and a new site as a control. Reactions were observed 4, 8, 24 and 48 hours after injection. The reaction pa tterns were almost the same at these three sites. No early reaction was observed at the site where tuberculin gad repeatedly been injected when the infant was not yet sensitive to it. 2) Influence of tuberculin injection on the subsequent tuberculin reaction at the same site in the subjects who were sensitive to tuberculin in the past but did not react to it at the time of the present experiment: A) 1/2,000 old tuberculin was injected in a new site on the right forearm in 23 school children. They had previously received B. C. G. inoculation and had once showed positive tuberculin reactions. But at the present experiment no reaction to the used tuberculin solution was observed. After one month tuberculin was injected again in the same site and in a new site as a control. Reactions were observed 4, 8, 24 and 48 hours after injection. At the repeatedly injected site early reactions and accelerated, intensified delayed reactions were observed in 17 out of 23 children in contrast to the new site. B) 1/50,000 old tuberculin was injected in a new site on the right upper arm in 11 adults, who had showed positive reaction to 1/2,000 old tuberculin. At the present experiment they all showed complete negative reaction to the 1/50,000 old tuberculin after 48 hours. After one month 1/2, 000 old tuberculin was injected in the same site and in a corresponding new site on the left upper arm. The observation times were the same in the first. At the previously injected site early reactions were observed in 8 out of 11 cases in contrast to the new site. In summary, these results show that when the injected subject was not sensitive to tuberculin, tuberculin injection had on influence on subsequent tuberculin reaction at the same site. And in contrast to this, when the injected subject was suspected to be sensitized to tuberculin, tuberculin injection can modify the reactivity of he skin area, even if it elicits no positive reaction. Consequently, it seems that the alteration of the reactivity of skin area by tuberculin injection needs the systemic tuberculin sensitivity as a postulate, but does not always need positive local reaction.
  • 中山 喜弘, 島貫 金男, 三之宮 愛雄
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 675-681,714
    発行日: 1965/12/30
    公開日: 2017/02/10
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    Follow up studies during period of over 5 years on patients with asthma in childhood were performed and obtained following results. The patients with non-symptomatic in 53.2%, improved in condition 27.6% and unchanged 14.9% were found while 2.2% expired during that time. The tendency of poor prognosis was observed in patients who had onset either in infancy or early childhood. The disappearance of symptoms at the age of six to seven years or thirtten were noticed in majority patients. Poor prognosis were seen in patients who have history of eczema. Also same tendency were observed in patients with no history of allergic diseases in their family. More effective results were obtained in the group of patients who had been treated more than a year, comparing with those of symptomatic treatment only.
  • 小泉 富美朝
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 682-703,715
    発行日: 1965/12/30
    公開日: 2017/02/10
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    This is a report of the immunopathological studies of the correlation between the chronic changes of serum protein, peripheral blood pictures and the morphological changes in the various organs in 30 rabbits, which were sensitized with egg white 2 times a week for over one year. Furthermore the inoculation of the tubercle bacilli of bovine type were performed on the prolonged sensitized rabbits. These results were summarized as follows. 1) The chronic changes of serum protein were characterized by hypergammaglobulinemia which had a peak in the earlier period (till 120 experimental days) and another peak in the later. 2) The chronic changes of serum protein were closely connected with the behaviour of the lymphatic follicles and the cell reactions in the haematopoietic organs especially of the lymph nodes and the spleen. 3) Methylgreen-pyronin staining of pyroninophilic cells indicated a defferent result in the earlier and later period, i, e. those in the earlier stage stained intensively, but weakly in the later and even non-pyroni-noophilic plasma cells were demonstrated. However, many intensive pyroninophilic plasma cells appe ared again in the lymph nodes and spleen of the cases which the inoculation of the tubercle bacilli was superimposed. 4) Nuclear changes in necrotic cells, LE transformation, HX bodies, and onion skin lesions were demonstrated in the group of the later period. 5) Hyperplastic bone marrow, remarkable myeloid metaplasia in the various organs and myeloid leukemoid reaction up to the promyelocytes in the peripheral blood were observed mainly in the earlier period, however, there was hypoplastic marrow in the later period, with single case (285th experimental day) which provided for change similar to myelofibrosis. 6) Experimentally produced Aschoff bodies in the heart have demonstrated, which became more typical form in the later period than those of the earlier period. From the evidences stated above, it may be possible to conclude that the processes of prolonged sensitization were divided into two periods, i.e. the earlier period which is characterized by showing an allergic-hypergic condition and the later having an abnormal immune response.
  • 原稿種別: 目次
    1965 年 14 巻 12 号 p. Toc1-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 八倉 隆保
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 705-706
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 奥村 悦之, 山中 直之
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 706-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 塩田 憲三, 浜田 朝夫, 三谷 建治, 松田 昌子, 小倉 隆保, 山村 雄一, 大島 良雄
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 707-708
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 外松 茂太郎, 藤沢 伸次, 富田 仁
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 708-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 安藤 格
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 709-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 国屋 輝道, 青山 恒夫, 原田 茂樹, 楠 智一, 安藤 格, 高井 俊夫, 松村 忠樹, 藤谷 哲造, 佐藤 義典, 塩田 憲三
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 709-710
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 山村 雄一
    原稿種別: 本文
    1965 年 14 巻 12 号 p. 711-
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 原稿種別: 文献目録等
    1965 年 14 巻 12 号 p. 712-715
    発行日: 1965/12/30
    公開日: 2017/02/10
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  • 原稿種別: 目次
    1965 年 14 巻 12 号 p. 716-720
    発行日: 1965/12/30
    公開日: 2017/02/10
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