アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
15 巻, 10 号
選択された号の論文の10件中1~10を表示しています
  • 原稿種別: 表紙
    1966 年 15 巻 10 号 p. Cover3-
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 表紙
    1966 年 15 巻 10 号 p. Cover4-
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 付録等
    1966 年 15 巻 10 号 p. App2-
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
  • 金子 由之助
    原稿種別: 本文
    1966 年 15 巻 10 号 p. 819-830,878
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
    In the past ten years, several investigators have attemped to isolate and purify the active allergens in "Maiko", a dust from Amorphophalus Konjac (which is also offending allergens of typical allergic asthma in human beings in Japan) by various chemical techniques and electrophoresis in starch. For the purpose of the present study, three water soluble fractions has been separated by fractional precipitation from "Maiko" extract. Precipitation was carried out at 0-40% saturation, 60-90% saturation and 0-90% saturation with ammonium sulfate. The antigenic specificity of these farctions has been shown by direct skin tests and passive transfer studies, bis-diazotized-benizdine method, gel diffusion method with the sera of Maiko sensitive patients, and by Schultz-Dale tests with iluem from sensitized guinea pigs. The results obtained were as follows: The 60-90% fraction was skin reactive, but the 0-40% fraction was noreactive. However, in bronchial provocation test, the 0-40% fraction was more reactive than the 0-60% fraction. Hemagglutination and geldiffusion data showed that both hemagglutinating and precipitating anti-gens are present in each fraction. Studies by the Schultz-Dale test schowed that the 0-40% fraction and the 0-60% fraction has different antigenic specificity. The 90% fraction was reactive in all tests.
  • 佐々木 高之輔
    原稿種別: 本文
    1966 年 15 巻 10 号 p. 831-843,878-87
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
    For the purpose of clarifying the pathophysiology of allergic reactions the role of serotonin was investigated in anaphylactic shock in experimentally induced rabbits as well as dogs, and in patients with bronchial asthma. Furthermore, the mast cells in the skin as well as the lung tissue of rabbits under the shock were observed. Results thus obtained were as follows. 1) The average serotonin levels of normal rabbits without sensitization were 0.70±0.16 μg/ml in the plasma, 3.04±0.24 μg/ml in the whole blood and 3.49±0.58 μg/g in the lung tissue. 2) After sensitization of the rabbits with egg white, they were 0.75±0.13 μg/ml in the plasma, 3.80±0.37 μg/ml in the whole blood and 3.75±0.66 μg/g in the lung tissue. Comparing these serotonin levels with those of normal rabbits, serotonin levels of only the whole blood were noted to be significantly, increased after the sensitization. 3) Determining the serotonin levels in plasma, whole blood, as well as lung tissue after administration of the antigen to the sensitized rabbits in an attempt to induce an anaphylactic shock, they were noted to be as follows. The plasma serotonin level increased three times as much as the level before the provocation from thirteen to thirty seconds after injection of the antigen and almost returned to normal level after one minute, however thereafter, it decreased to lower level than those before provocation from three to five minutes after the antigen was given. On the other hand, the whole blood serotonin demonstrated remarkable decrease from thirteen to thirty seconds after injection of the antigen showing no signs of recovery until after five minutes. 4) The serotonin level of the lung tissue from six to seven minutes after injection of the antigen was 11.08±0.91 μg/g in average which level was significantly higher than those of normal as well as sensitized rabbits. From sixty to ninty minutes after injection of the antigen, the serotonin level of the lung tissue was noted to return to normal level. 5) In rabbits under anaphylactic shock the mast cells of the skin as well as the lung tissue revealed various histopathological changes such as swelling, degranulation and destruction. These changes were more striking than those of the non-sensitized group given the antigen. 6) When an anaphylactic shock was induced in rabbits, their leucocyte and platelet counts decreased remarkably. These changes ran almost parallel with the rise and fall of the whole blood serotonin. 7) The average plasma serotonin levels were 0.083±0.0022 μg/ml in normal dogs without sensitization 0.128±0.018 μg/ml in the dogs sensitized with horse serum and 0.235±0.032 μg/ml in the latter thirty seconds after injection of the antigen to induce an anphylactic shock. There was no significant difference in the plasma serotonin level between the non-treated dogs and the sensitized dogs, whereas the plasma serotonin level of dogs during anaphylactic shock showed a remarkable increase which value was noted to be significantly higher than the same of the non-treated as well as the sensitized dogs before provocation of the anaphylactic shock. The blood pressure of the sensitized dogs began to decrease at thirty minutes after the provocation, plasma serotonin level was noted to already return to the pre-provocation level three minutes after provocation injection of the antigen. The clinical symptomes of anaphylactic shock appeared a little later after the plasma serotonin level reached its peak. 8) The average plasma serotonin level of healthy person was 0.80±0.019 μg/ml in average. The average plasma serotonin level in the patients with bronchial asthma was 0.083±0.035 μg/ml in their symptom-free periods and 0.148±0.083 μg/ml during their paroxysm periods, which level was noted to reveal a significant increase in comparison with the plasma levels of both healthy persons and asthmatics without paroxysm. 9) Thirty minutes after the intravenous injection of dexameth
  • 中島 伸之
    原稿種別: 本文
    1966 年 15 巻 10 号 p. 844-863,879-88
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
    In connection with immunological processes of homograft rejection, a comparative study was performed on hetero-, homo- and autotransplantation in the rat. Hetero (rabbit)-, homo- and autogenous splenic tissues were transplanted into th omentum of rats. Tissue changes taking place around the graft as well as in itself were examined histo-pathologically at intervals. The following results have been obtained. 1) The graft tissues were organized completey in thirty days with newly formed granulation tissue in hetero- and homotransplantation, whereas some lymphocytes and reticular cells were still slive at this time without marked proliferation of granulation tissue in autotransplantation. The necrotizing processes of the graft tissue and it organization resulting fibrosis were most profound in hetero transplantation. 2) Basophilic globular corpuscles originated in nuclear substance morphologically resembling hematoxylin bodies were observed in graft tissues. The precise causal genesis of development of the corpuscles obtained here, however, still remained indefinite in the present study. 3) Proliferation of the granulation tissue surrounding the graft was most evident in heterotransplantation, moderate in homotransplantation, and scarcely recognized inautotransplantation. 4) In the serum of the rat with hetero- and homotransplantation, antibody against donor's red cells was found by the hemagglutination test, respectively. From these findings, it has been concluded that the proliferation of granulation tissue surrounding the graft may be a focal immune reaction at the omentum tissue attempting the rejection of transplanted tissue.
  • 原 一郎, 守島 黎子
    原稿種別: 本文
    1966 年 15 巻 10 号 p. 864-869,880
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
    Alkylbenzensulfonate (ABS)-egg albumin (EA)- and alkylbenzensulfonate-bovine serum albumin (BSA)-complexes (ABS:EA, ABS:BSA) were prepared by mixing each component dissolved in water at pH 7.0-7.5, respectively. Two sorts of ABS, tetrapropylene type and normal alkylene type were used. Each complex comprising 10 mg of protein in the ratio of ABS/protein = 3 was twice injected in rabbits according to Freund's adjuvant method followed by three subcutaneous injections with 1 mg of protein in the ratio of ABS/protein = 3. According to the ordinary precipitin reaction, we found 1 positive reactions in ABS-anti ABS:EA, and ABS:EA-anti ABS:EA systems, And we also saw 2 positive reactions in the case of BSA-anti ABS:BSA, 2' or 1 positive reactions in that of ABS:BSA-anti ABS:BSA, respectively. But ABS solution concentrated more than 0.04% of ABS showed 1 or 1' positive reactions with all rabbit sera. Titers of antibody were 1:1 in EA-anti ABS:EA system against 1:256 or 1:512 in that of EA-anti EA, and 1:4 or 1:8 in the case of BSA-anti ABS:BSA against 1:16 or 1:32 with BSA-anti BSA. Arthus phenomenon showed 2 positive reaction for BSA: anti ABS:BSA system against 4 positive reaction with BSA-anti BSA system.
  • 進藤 宙二
    原稿種別: 本文
    1966 年 15 巻 10 号 p. 870-875
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
  • Bram Rose
    原稿種別: 本文
    1966 年 15 巻 10 号 p. 876-877
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 文献目録等
    1966 年 15 巻 10 号 p. 878-880
    発行日: 1966/10/25
    公開日: 2017/02/10
    ジャーナル フリー
feedback
Top