House dust is one of the most important antigen for patients with respiratory allergy, but its constitution is very complexed and is considered not to be the same either in each house or in each place. In this report, the incidences of positive reaction of skin test with house dust antigen in various districts of Japan have been comparably studied and further the skin test with house dust antigen itself was studied in some detail giving the following results: 1. The incidences of positive reaction of skin test with house dust antigen in various districts of Japan were from 4% to 32% or 16% in average in the so-called healthy persons, from 31% to 100% or 65% in average in the patients with bronchial asthma, from 3% to 22% or 19% in average in the patients with chronic urticaria, 20% in average in the patients with oyster-shucker's asthma and 28% in the patients with other allergic disorders. 2. The relationship between the skin test with house dust antigen and the age of subjects examined was studied. In the so-called healthy persons, the incidence of the positive reaction of skin test with house dust antigen was seen already from the teens and showed its peak in the latter half of the twenties and the first half of the thirties and then gradually decreased, but even the seventies a positive reaction was still found. In the patients with bronchial asthma, there was a difference between the patients in Morioka and those in Hiroshima in the incidence of positive reaction of skin test with respect to the age of the patients, but on an average two peaks were seen in the incidence of positive reaction of skin test, that is one in the age period of from five to fourteen years and the other in the same of from thirty to thirty-four years of age. As to the relationship between the age of onset of bronchial asthma and the skin test with house dust antigen positive reaction was seen in a highincidence in patients whose onset of asthma was before fourteen years of age, and thereafter showed gradual decrease in its incidence with advance of age. 3. The incidence of positive reaction of skin test in asthmatics with house dust antigens extracted from house dusts collected in the houses of each asthmatic varied from 0% to 60%, the same house dust antigen showing even a difference between Morioka and Hiroshima in the result of the skin test. The incidence of positive reaction of skin test with patient's own house dust antigen was high and there were some patients who reacted only with their own house dust antigens. 4. In three hundred and fourty-three patients with bronchial asthma, the incidence of positive reaction of skin test with all the antigens examined was 64%, of which 52% were with house dust antigen. Seeing these skin tests from viewpoint of age of the asthmatics, an incidence of positive reaction with antigens other than house dust was slightly high in the patients from the teens to the thirties and from the viewpoint of age of onset of asthma it showed a high peak in the latter half of the teens of asthmatics which was noted not to be parallel to the incidence of positive reaction with house dust antigen. 5. As to the relationship between the skin test with house dust antigen and hereditary disposition, while asthmatics who had the disposition showed a high incidence of positive reaction, asthmatics without the disposition demonstrated no remarkable difference between the positive and negative incidence of the reaction. 6. As to house dust antigen therewas a significant correlation between its skin test and Prausnitz-Kustner reaction, but no correlation was found between its skin test and leucocytolysis in vitro. 7. Regarding the relationship between the hyposensitization treatment and skin test with house dust antigen, the reaction of skin test became weak in most of the patients, in whom the hyposensitization treatment was favourable, but it did not show change in
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