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Volume 16, Issue 4
Displaying 1-12 of 12 articles from this issue
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Article type: Cover
1967 Volume 16 Issue 4 Pages Cover12-
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (46K) -
Article type: Cover
1967 Volume 16 Issue 4 Pages Cover13-
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (46K) -
Article type: Appendix
1967 Volume 16 Issue 4 Pages App11-
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
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Setsuo KobayashiArticle type: Article
1967 Volume 16 Issue 4 Pages 227-231,297
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPractice of Hyposensitization therapy was presented. The following criterions were notified for the technique. 1) Dosage: Half of an dose which gave a moderate reaction on intradermal skin testing was used as initial dose, and increased up to maintenance dose weekly. After reached the maintenance dose switched the injection to monthly. All injections were given subcutaneously. 2. Signs which would indicate alteration of dosage: After the injection, if local swelling more than 5 cm, unusual pain, or any systemic reaction occured momemtarily or within four hours, the next dose was reduced. All patients had to wait at least 15 minutes after the injection. Intervals of the injection up to 14 days, dosage might be increased regularily. Dosage might be repeated if the interval did not exceed 28 days. After this interval the dosage had to be reduced by 25% for each week over four weeks. 3) Maintenance dose: If the patients could tolerate up to recommended dose: depends the strength of antigenicity, it was maintenance dose, otherwise the maximum dose which did not produce any untoward reaction was used as maintenance. 4) Discontinuing of the hyposensitization therapy was considered after 2 year nonsymptomatic period.View full abstractDownload PDF (831K) -
Tohru Abe, Sachu Shimada, Rokuro OsakoArticle type: Article
1967 Volume 16 Issue 4 Pages 232-239,297
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSHaemotological and histological analysis was made in runted animal which was produced experimentaly by use of F_1 hybrid rat. Runting occured in 30.7% among animals studied but occurence ratio was influenced not only by combination of species but also direction of graft of immunological competent cells. Runting was easily recognized by dermatitis, conjunctivitis, weight los and diarrhoe. Survival of runted animals was inversely proportional to latent period. Adrenocortical steodri hormone was effective for toxic manifestation such as dermatitis, conjunctivitis but tended to accerate infection and immunological imcompetency of host. Anemia, Leukopenia in hematology, decrease of γ-globulin with increase of alubumin were pertinent laboratory findings. Serologicaly, direct coombs test was positive in 15.7%, γ-globulin consumption test in 45%, but no LE cell was detected in spite of repeated examination. Spleen in runted animals became enlarged up to about 1 week, then decreased in size. Thymus kept decrease through entire course. Histologicaly, atrophy of lymph follicule, decrease of Lymphocyte, increase of reticulum cells and fibrosis were prominent. Bone marrhow showed entire decrease of cellular elements and thymus was decrease of parencyhmal cells, disappearence of Hassal corpuscle with increase of phagocyte and mononuclear cells.View full abstractDownload PDF (1177K) -
Matsuko WatanukiArticle type: Article
1967 Volume 16 Issue 4 Pages 240-248,298
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBy observing that there was no obvious relation between the hemagglutination titer in the Middlebrook-Dubos indirect hemagglutination test and the hemolytic titer in the hemolytic modification of the test, the duality of antibody responsible for these two reactions has been discussed repeatedly. Some attempts to separate each antibody have not satisfactorily made, by using paper electrophoresis and DEAE-celllose column chromatography. In order to approach this problem from other aspect, the author attempted to see if the two serologic reactions could dissociate in the course of 19S and 7S antibody response. The serum of guinea pigs was fractionated by Sephadex-G-200 gel filtration at 2, 4, 6, 11, and 16th week after the sensitization with killed tubercle bacilli suspended in paraffine oil. Antibodies included in the first two major fractions of the chromatogram was confirmed to have sedimentation coefficients of 19S and 7S, respectively, by using ultracentrifugal and sucrosd density gradient analysis and sensitivity to 2-mercaptoethanol. The hemagglutination and hemolytic activities were observec to appear and proceed independently from each other in the two fractions, early in 19S ane late in 7S fractions as indicated below. In combination with the above analysis, starch zone electrophoretic studies indicated that these fast and slow sedimentating antibodies were 1gM and 1gG, respectively. 1) The hemagglutination reaction could be observed early only in the 19S class antibody fraction ahead of the hemolytic reaction, being maintained for a longer period of time until the 16th week in this macromolecule fraction. On the other hand, the hemagglutinating activity in the 7S-fraction was detected at 11th week after the sensitization still in low titer. 2) The hemolytic activity appeared first at 4th week in the 19S fraction and then rapidly transfered to 7S fraction at 6th week. After 11th week no hemolytic activity was detected in the 19S fraction, while the activity in higher titer was found in the 7S fraction. The results can be interpreted as evidence that the antibodies which are measured in the two reactions are different.View full abstractDownload PDF (1261K) -
Yoshiyuki IgakiArticle type: Article
1967 Volume 16 Issue 4 Pages 249-269,298-29
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo determine serum complement levels in 79 patients with nephritis, C' and C'1, and immune adherence (I.A.) were estimated by the methods of Mayer's and Nelson-Nishioka's, respectively. During the first week after the onset of acute glomerulonephritis, both C' and I.A. were extremely low, C'1 being normal. As to the lowered C's, they mostly returned to normal in three weeks, while the depressed I.A. remained unchanged during the entire course of illness in most cases. In all the patients with acute glomerulonephritis which tended to heal or prolong, and chronic glomerulonephritis which was in latent, progressive or terminal stage, both C' and C'were normal, while I.A. showed low values. In patients with nephrotic syndrome, there was an extremely fluctuated serum complement level, with very low values in some cases. However, the cases, with improved proteinurias by steroid treatmentsin vitro and in vivo has no decreasing effects on C'. In the initial stage of subacute nephritis, C' remained low for prolonged periods of time. The C' of patients with chronic glomerulonephritis with frequent exacerbations was subnormal, but it temporarily became normal during and/or immediately after exacerbations. In patients with lupus nephritis, both C'and I.A. correlated well with their clinical states. Tonsillectomy was not followed by significant decrease in C', C'1 and I.A. values. Positive correlation between C'and I.A. found in this study suggests that the changes of C' result from that of I.A.View full abstractDownload PDF (2821K) -
Momoe SoedaArticle type: Article
1967 Volume 16 Issue 4 Pages 270-276
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt is well known that production of tolerance in previously immunized animals has been achieved only after injection of very large doses of antigen. One reason for this difficulty may be that circulating antibody may combine with a given dose of antigen and form antigen-antibody complexes which are rapidly removed from the circulation. It also seems likely that successful clinical hyposensitization of atopic patients may be analogous to the production of tolerance in previously immunized subjects. In an attempt to follow up the fate of such complexes after their removal from the circulation, I have searched for urinary components of atopic patients which are capable of causing some serological reactions with their sera. I have found out an urinary component, named MS-antigen, which can react with patients' sera and cause precipitation reaction. It is also capable of producing precipitin of high titers in animals and humans when it is injected at proper intervals. It has neither skin sensitizing properties nor allergy provoking effect, however, clinical hyposensitization can be successfully achieved in various atopic patients by repeated injection of auto-MS-antigen. This substance is non-toxic and can be used quite safely for clinical purposes. Over 100 atopic patients with asthma bronchiale, acute and chronic ulticaria, allergic rhinitis, atopic dermatitis etc have been treated in this wasy with significantly favorable results. Here I will report on the pattern of precipitin production in animals and humans, the relationship between titers of precipitin production in animals and humans, the relationship between titers of precipitin and patients' clinical course, serological typing of MS-antigens and the favorable results obtained from clinical application of MS-antigenView full abstractDownload PDF (764K) -
Kazuo FuruyaArticle type: Article
1967 Volume 16 Issue 4 Pages 277-288,299-30
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAir born pollen survey was carried out at Sagamihara National Hospital in Sagaminara City, Kanagawa Prefecture from 1960 to 1963 and in 1965. 1) There were 4 pollinating seasons in a year: a) the 1st season was the tree season from the end of Feb. to the middle of May and showed the highest peak of pollen conts in the 4 seasons, b) the 2nd was from the end of May to the middle of Aug. and showed reratively low counts, c) the 3rd was from the end of Aug. to the middle of Oct. and fairly many pollens of grasses and weeds were counted, d) the 4th was from the end of Oct. to the middle of Feb. and few pollens were seen. 2) Predominant pollen grains were Cryptomeria japonica, Chamaecyparys sp., Pinus sp., Miscanthus sinensis, and Artemisia sp., and in some years Zercowa serrata, Quercus sp., Macleya cordata, Erigeron sp., and Pennisetum japanicum. 3) Pollinating period began at the end of Feb . and continued till the middle of Oct. every year. The highest peak of pollen counts during the above-mentioned 4 years was found on April 1, 1961, namely 536 pollen grains per 1 cm^2. 4) Pollen counts performed at the height of 1.4 m , and 10.8 m above the ground differed sometimes, and it was considered to be influenced possibly by the surrounding conditions. 5) Species of pollens and pollinating period showed little change, but pollen counts changed remarkably according to the year. 6) The results of pollen counts using our pollen survey device were 1.2-1.4 times higher than those using the standard sampling pollen device. 7) Pollen counts were more abaundnt on fine days than on rainy days, but on cloudy days they were not necessarily few. Excluding rainy days, pollen counts had some positive correlation with relative humidity below 80%View full abstractDownload PDF (1599K) -
Yoshitaka Miyanaga, Keiichi HashimotoArticle type: Article
1967 Volume 16 Issue 4 Pages 289-296,300
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAnti-bradykinin rabbit serum was obtained by injecting bradykinin with complete Freund's adjuvant and the antibody was analysed by column chromatography, electrophoresis and ultra centrifugation and the antibody titer was estimated by bradykinin sensitized red cell haemagglutination technique. Brandykinin levels in blood was determined by bradykinin sensitized red cell hemagglutination inhibition test and the results obtained were as follows: 1) Antibody fraction reacting to bradykinin was eluted by DEAE cellulose column chromatography with 0.1 M phosphate buffer (pH 7.0) and the sensitized red cell haemagglutination titer of the fraction was 2560. 2) This fraction seemed to belong to 1gA by electrophoresis and the fraction was stable to heat. 3) By the analysis with ultra centrifugation the fraction was found to be consisted with two proteins: one is 6S (80%) and the other is 13S(20%). 4) Bradykinin levels in blood was determined by bradykinin sensitized red cell haemagglutination inhibition test and it was demonstrated that bradykinin level of blood in urticaria patients were about 10 holds higher (0.5-1.0 mcg/ml) than normal human sera. Also the bradykinin titer was found to be increased in the same sera by treating with trypsin.View full abstractDownload PDF (1085K) -
Article type: Bibliography
1967 Volume 16 Issue 4 Pages 297-300
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (331K) -
Article type: Bibliography
1967 Volume 16 Issue 4 Pages Misc1-
Published: April 30, 1967
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (64K)
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