This experiment was performed for the purpose of clarifying the genesis of expermental allergic encephalomyelitis (EAE) in relation to human encephalomyelitis. In this present report cerebral anaphylactic shock was induced by single injection of the anti-rabbit brain rat and guinea pig serum into carotid artery of rabbits and these histological changes in brain caused by reversed anaphylaxis were investigated. The major patho-histological changes were found as follows, 1) The degeneration, atrophy, necrosis of nervous tissue, neuronophagia and focal and/or diffuse glial proliferation, 2) The perivascular infiltration of small round cells, congestion, thrombosis and several degree of edema, 3) Proliferation of ependymal cells, demyelination besides these changes and lucid plaque which is synonym of the patch of necrosis, and found in the brain tissue. In general, these demylination were circumscribed and located in perivascular area; in some instance, no definite relationship to blood vessels was apparent, in any others there were several foci with tendency to coalesce together. 4) In the regions of severer reaction, there was focal necrosis and hemorrhagic necrosis. On the contrary no significant changes were found in the control rabbits by injectin the normal rat and guinea pig serum by similar method. These patho-histological changes were found similar to those in the experiment using erythrocytic antigen and in this present experiment the parenchymal tissue damage in brain was much more prominent. These observation indicate that the pathogenesis of encephalitis and demyelinating disease may be of "allergic mechanism".
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