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Volume 17, Issue 3
Displaying 1-17 of 17 articles from this issue
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Article type: Cover
1968 Volume 17 Issue 3 Pages Cover9-
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (62K) -
Article type: Cover
1968 Volume 17 Issue 3 Pages Cover10-
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (62K) -
Article type: Appendix
1968 Volume 17 Issue 3 Pages App11-
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
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Takaaki YagiArticle type: Article
1968 Volume 17 Issue 3 Pages 141-152,233
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSContinuing the investigation of the previous report, the author divided the kidney of rabbit into two portion, which was cortical portions and medullar ones. Anti-renal medulla sera were produced in guinea pigs by intraperitoneal injection of suspensions os blood free medullar portions of rabbit kidneys. The nephrotoxin of these sera were injected into the pregnant rabbits intravenously. One day, and one or two weeks after the injection these rabbits were sacrificed and investigated about histological changes in the kidneys. On a majority of the animals, remarkable changes in the kidney were observed as follows. 1) anemia and hyaline thrombosis in the glomerular loops. 2) swelling, degeneration and proliferation of the glomerular mesangial cells. 3) adhesions of glomerular loops and eosinophilic substances in the Bowman's capsuled. 4) degeneration of tubular epithelium and hyaline casts in the tubules. Similar renal changes to these diffuse glomerulitis with nephrotic changes were observes on the previous experiments by Takagi and Irino using anti-renal cortex serum of the rabbits. The results of the author's experiments suggest the existence of antigenicity in the medullar parts of the kidneys.View full abstractDownload PDF (1829K) -
Yukinobu KobataArticle type: Article
1968 Volume 17 Issue 3 Pages 153-163,233
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe morphological changes of single cells on a cover slide previously inserted into subcutaneous tissue of rabbits or guinea pigs pretreated with tubercle bacilli or other antigens were observed under a supravital condition by adding antigens from tubercle bacilli or corresponding antigens. Old tuberculin or tuberculo-protein provoked "cellular shocking" on cells from tuberculo-sensitized animals, but not from non-sensitized. The "shocking" represented cellular constriction forming cilliary projections at first and many blisters lately on the surface of the cells. The time course of the shocking was about 6 to 8 hours and this corresponded to the delayed type of allergic reaction. Protein antigens such as egg albumin or allogenic sera caused minimal morphological changes because of the acute death after anaphylactic reactions of the sensitized cells. Reactions on cells after immersing in their antisera from allogenic animals were intensive enough to occur prompt plasmolysis and cell explosion. These morphological changes on a single cell corresponded to the immediate type of allergic reaction.View full abstractDownload PDF (2023K) -
Kiyotaka ItoArticle type: Article
1968 Volume 17 Issue 3 Pages 164-178,234
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTherapeutic efficiency of hyposensitization in those cases of bronchial asthma in which the house dust was highly suspected on clinical basis to be a causative agent as an allergen was evaluated. Total 194 patients were given repeated hyposensitizing injections with a house dust extract and observed for at least one year. The effect of the hyposensitization was evaluated according to our criteria for the therapeutic efficiency that were made mainly considering a shift in the severity of the disease. The hyposensitization therapy was effective in 106 (54.7%) of the 194 cases observed for more than one year, in 72 (50.0%) of the 144 cases observed for more than two years, and so in 30 (39.5%) of the 76 cases followed up for more than three years. The therapeutic efficiency thus appeared to be lowered as the observation period was extended. Influences of various back ground factors on the therapeutic efficiency were summarized as follows:the patients of a younger age, with a shorter duration of the disease, with either atopic, seasonal or acute type of the disease, and the relatively mild cases responded much better to the hyposensitization therapy than those of an old age, with a longer duration. with either mixed, nonseasonal or chronic type, and the relatively severe cases. As to the frequency of injection with the maintenance dose, the group injected more than once a month showed a better response to the therapy than that injected only once a month. Changes in the skin reactivity to the house duct extract tested before and one year after the beginning of the therapy failed to correlate to the therapeutic efficiency.View full abstractDownload PDF (2090K) -
Terumasa Miyamoto, Yukio Matsumura, Taro Kodama, Tsuneko SaitoArticle type: Article
1968 Volume 17 Issue 3 Pages 179-182,234
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSGuinea pigs and rabbits were exposed to 300 to 400 ppm of sulfur dioxide for 30 minutes. Following this, 1% of bovine serum albmine and egg albumine were aerosolized for 30 minutes into the exposure box, where sulfur dioxide preexposed animals and control animals were placed together. This ptocedure was repeated for seven times every other day. Two weeks after the last exposure, blood was drawn from each animals and antibody titer was determined by tannic acid treated red cell hamagglutination test and passive cutaneous anaphylaxis. It was found that antibody titer was significantly higher in the pretreated animals.View full abstractDownload PDF (637K) -
Tadashi Ofuji, Minoru Morita, Hajime Sato, Shiyoji Miyawaki, Seizo Yam ...Article type: Article
1968 Volume 17 Issue 3 Pages 183-187,235
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe have been reported successful production in experimental diphasic anemia with i.e. A and B phases, by transfer of rabbit anti-guineapig red cell serum to guineapigs. In this report, we investigated whether or not the incomplete antibody which could be detected in this experiment was true autoimmune antibody and if so, what the mechanism of its production was. The results obtained coombs test fluorescent antigen and antibody methods showed that hemolysin, agglutinin and incomplete antibodies in the anti-serum transfered into guinea-pigs were specifically combined with red cells of guinea-pigs. In the next step of the experiments, production of antibodies in guinea-pigs against the transfered antibody was demonstrated by means of absorption test with rabbit. γ-globulin, fluorescent antigen and antibody methods with conjugates of rabbit γ-globulin and anti-guinea-pig globulin, and coombs test with rbabit anti-guinea-pig globulin serum. The similar results were obtained by transfer of guinea^pig serum and red cell eluate. Thymectomy of newborn guinea-pig did not exert detectable effect upon this anemia but additional application of glycirrhizine suppressed production of the antibody. In summary, it could be demonstrated that heteroimmune antibody played the most significant role in production of the antibody in this experimental system.View full abstractDownload PDF (799K) -
Hiroshi HayakawaArticle type: Article
1968 Volume 17 Issue 3 Pages 188-209,235-23
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to detect the immunological function of the donor, peripheral blood lymphocytes were cultured in vitro for three days with Phytohaemagglutinin (P.H.A.). Appearance ratio of the large transformed cells in 1000 mononuclear cells were counted and autoradiographs by tritium thymidine were also made. The results were as follow: 1) In the control subjects without any immunological defect there was no significant difference in the appearance ratio (A.R.) of transformed cells in 27 children and 34 adults, aged from 17 to 56. No difference was also seen between male and female. 2) The patients with bronchial asthma (40 cases), other allergic diseases (7 cases) and collagen diseases (4 cases) did not show significant difference in A.R. as compared with that of the control subjects. 3) Eight of nine patients with uremia showed significantly low A.R.. 4) in all three cases with ataxia telangiectasia, whether they had Ig A in their serum or not, A.P. was significantly lower than that of the controls. 5) Ten cases of leukemia and three cases of Hodgkin's disease showed low A.R.. 6) With P.H.A. of ordinary dilution 14 patients with the Down's syndrome showed no different A.R. as compared with that of the control subjects, but with diluted P.H.A.(1:100) they showed significantly higher A.R. than that of the controls. Therefore hyperresponsiveness to P.H.A. in the Down's syndrome was suggested. Autoradiographic study revealed the similar results with those stated above concerning the appearance rate of labelled cells. The results above mentioned suggested that this system, in vitro culture of peripheral lymphocyte with P.H.A., well reflected and would be useful to detect donor's immunological condition on cellular level.View full abstractDownload PDF (3330K) -
Hiroshi HayakawaArticle type: Article
1968 Volume 17 Issue 3 Pages 210-227,236
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPeripheral blood lymphocytes were cultured with or without antigenic substance with which the donor might have been previously sensitized. After five days large transformed cells were counted in 1000 mononuclear cells and the result was called 'positive' in case the appearance ratio was three times higher than that of control cultures without any antigenic substances. Autoradiographs by tritium thymidine were made for selected cases. The results were as follow: 1) All six tuberculin-PPD positive donors showed 'positive' reaction and four of seven donors who were negative in skin reaction showed 'positive' reaction. 2) In 84 asthmatic children who showed positive skin reaction to any one of four allergen extracts (House Dust, Ragweed, Cotton and Wool), 28 cases showed positive response in this system, while among 35 patients who showed negative skin reaction only one case showed positive response. The difference was significant. (p<0.01) Ragweed sensitivity showed the most remarkable response. 3) Three patients who were suffered from drug allergy to Control, ACTH or Streptomycin showed positive response to each drug, while the control subjects showed no positive response. 4) Three children with collagen diseases (S.L.E., rheumatoid arthritis and dematomyositis) were tasted with the extract of autologous leukocytes, but no positive response was demonstrated. 5) Mixed leukocyte (lymphocyte) cultures were performed between two donors. There were two positive cases among the eleven cultures between the relatives, while thirteen positive cases were seen among the 24 cultures between the non-relatives. The higher positive reaction in the non-relatives was thus significant. (p<0.05) Autoradiographic study revealed the similar results with those stated above concerning the appearance rate of labelled cells. The results above mentioned suggested that this method was useful to detect donor's condition about sensitization to some antigens in vitro on cellular level in many types of immunological reaction.View full abstractDownload PDF (2147K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1968 Volume 17 Issue 3 Pages 228-
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1968 Volume 17 Issue 3 Pages 228-229
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1968 Volume 17 Issue 3 Pages 229-
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (195K) -
[in Japanese], [in Japanese]Article type: Article
1968 Volume 17 Issue 3 Pages 229-
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (195K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1968 Volume 17 Issue 3 Pages 229-232
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1968 Volume 17 Issue 3 Pages 232
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (246K) -
Article type: Bibliography
1968 Volume 17 Issue 3 Pages 233-236
Published: March 28, 1968
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (311K)
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