Since the start of the Allergy Centre here, the hyposensitization treatment has been carried out in asthmatic patients. In this report the author reports about the results of clinical studies on the effect of hyposensitization treatment during the past three years and a half. The allergen extracts (the greater part being sold, and partly self-prepared) applied to this therapy. And they were house dust, common ragweed pollen, cat's-tail pollen, cryptomeria pollen, silk, mulberry timber, tea, mixed bacteria, aspergillus mould, and so on. The patients were injected intracutaneously the initial dosage of allergen extract as much as 0.02 cc of 10% dilution of threshold to positive intracutaneous reaction(the greatest antigen dilution). The injections were carried out two times a week, and the dosage was increased step by step(about 50% every time)to reach to the maintenance dosage. It was 96 cases who were treated with hyposensitization therapy. But in 25 cases the injections were withheld within 3 months(3 cases presenting severe local reaction or asthmatic attack immediately after injection), and 11 cases were suitably reserved to estimate the effect of the treatment. Therefore, it was after all 60 cases that were the object to be estimated the effect of hyposensitization treatment. Favourable effects(marked effects as in the following parentheses) were observed in 60.0%(30.0%)of serious 10 cases, in 65.2%(34.8%)of 46 middle-grade serious cases, in 100% of 4 less serious cases, and to sum up all, in 66.7%(38.3%)of the total 60 cases, especially in 70.3%(40.7%)of the 27 subjects whose clinical schedule was regularly checked for over one year at least. The above mentioned result of our study on the clinical effects of hyposensitization treatment was nearly the same as were reported by many other preceding investigators. The proper quantity of antigen extract as maintenance dosage was different case by case. In majority of the subjects the dilution of 10^-2〜10^-3 was appropriate for this purpose, while the dilution of 10^-1 was applied to some cases. And it is necessary not to be over dosage. As to the period of duration, the author considers that the hyposensitization therapy should be continued as long as possible in case the favourable effect is gained. It is because in some cases asthmatic attacks disappeared while this treatment was carried on for a year to three years and two months, in contrast, however, in some cases taking a favourable course with the hyposensitization treatment, asthmatic attacks began to break out again few months after the stop of this therapy.
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