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原稿種別: 表紙
1969 年 18 巻 12 号 p.
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発行日: 1969/12/30
公開日: 2017/02/10
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原稿種別: 表紙
1969 年 18 巻 12 号 p.
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発行日: 1969/12/30
公開日: 2017/02/10
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大塚 正, 勝谷 隆, 城 智彦, 折田 良造, 浜口 美博
原稿種別: 本文
1969 年 18 巻 12 号 p.
955-958,1046
発行日: 1969/12/30
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Sea-squirt asthma is a typical allergic and occupational asthma caused by inhalation of sea-squirt substances. Therefore, the treatment and the prevention of this disease was emphasized on improvement in the occupational environment along with the specific hyposensitization therapy. Since in the last two to three years, there has been rapid and remarkable improvement in the environment and equipment of the working place, the comparison was done between the improvement of occupational environment and the occurrence of sea-squirt asthma before and after this change (viz. Feb. 1963 and Feb. 1968 respectively). Following results were obtained. 1) The complains of asthmatic symptoms were 45.8% for the former and 30.1% for the later. 2) The percentage of the severe asthma decreased from 64.5% in the former case to 20.0% of the later. 3) There were no patients who could work without asthmatic symptom in the former cases, but symptoms free in the 34 cases out of 90 patients in the later. 4) In the former cases, a tendency of almost all the mild illness becoming sever was noted, but there was no such tendency in the later.
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小玉 正智, 久保 雄治, 若林 敏之, 近松 重義, 永田 富雄, 川井 啓市
原稿種別: 本文
1969 年 18 巻 12 号 p.
959-965,1046-1
発行日: 1969/12/30
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1) Anti-gastric mucosal antibody was obtained with immunization of rabbits with gastric mucosal antigens. 2) This antisera showed cross-reactions with the antigens of the sera, kidney, intestine, colon and thyroid glands. After absorption with these antigens, the organspecific antibody of gastric mucosa was obtained. 3) The specific anti-sera represented 6 precipitin-line in the gel-diffusion test with the antigen of its own. Partially overlapped one antigenicity was observed between the human and dog's gastric mucosa. 4) Localization of antigenicity was represented with fluorescence antibody technique. The specific fluorescence was observed at the cytoplasma of the epitherial cells, the chief cells and parietal cells. 5) With the use of absorption tests with the each fraction of cell-fractionation of gastric mucosa, the specific antigenicity was detected in the microsomal fraction. A Single-blind Trial of Disodium Cromoglicate (Intal) in the Treatment of Allergic
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石川 芳久
原稿種別: 本文
1969 年 18 巻 12 号 p.
966-972,1047
発行日: 1969/12/30
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Twenty healthy subjects and eighteen patients with SLE were examined immunologically. Serum complement level (CH_<50>) and immune adherence (CIA_<50>) decreased remarkably in exacerbation of SLE. These patients exhibited a mean elevation of Ig A, Ig M and Ig G in acuteness of the disease, but β_<1A>globulin decrased. β_<1A>globulin level correlated with degree of elevation and decrease of CH_<50> and CIA_<50>. So determination of β_<1A>globulin could be substituted for C_3 measurement by CIA_<50>. In moderate stage of SLE β_<1A>globulin and Ig M level returned towards nor mal, but Ig A and Ig G showed a significant increase. It was thought that serial higher levels of Ig A and Ig G in remission resulted from moderate increase of erythrocyte sedimentation rate. The changes of CIA_<50> and CH_<50> did not correlated with transferrin containning of C_3 inactivator and transferrin showed almost normal level in each stage of excerbation and remission. In chronic discoid lupus erythematosus, all of immunoglobulin, β_<1A>globulin and transferrin exhibited normal range.
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松村 龍雄, 黒梅 恭芳, 塚越 寛
原稿種別: 本文
1969 年 18 巻 12 号 p.
973-979,1047
発行日: 1969/12/30
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In skin testing with PPD, in addition to delayed reaction, immediate reaction was observed as follows: The reaction reached the maximum within 10 to 15 min and was characterized by a definite wheal and marked erythema, accompanied sometimes by pseudopodia. In immediate reaction to PPD, results were as follows: (1) The immediate reaction to PPD was observed in about 43% of children with pulmonary tuberculosis and in about 16% of healthy children previously vaccinated with BCG. (2) Whenever the immediate reaction to PPD was positive, the delayed reaction was also positive. (3) the immediate reaction was produced at a lower concentration of PPD in children with pulmonary tuberculosis than in healthy children. (4) The immediate reaction fell positive sometimes at a lower concentration of PPD than that of the delayed reaction. (5) There was an optimal concentration of PPD capable of eliciting the immediate reaction in individuals with a range of optimal concentrations varying widely according to subject. (6) Passive transfer tests to recipients via serum of donors who reacted strongly positive for the immediate reaction was successfully accomplished. From these results, it might be concluded that the immediate reaction to PPD was of a specific nature due to an antigen-antibody reaction based upon previous sensitization.
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我妻 義則, 信太 隆夫, 松山 隆治, 宮田 亮, 伊藤 浩司
原稿種別: 本文
1969 年 18 巻 12 号 p.
980-990,1048
発行日: 1969/12/30
公開日: 2017/02/10
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Twelve cases of pollinosis and 13 cases of pollen asthma caused by Ezo-Yomogi(Artemisia montana) pollen were examined in Sapporo, Japan. Artemisia montana is the most common species of this genus in Sapporo. On pollen surveys, Ezo-Yomogi pollen was found from the middle of August to the end of September. High sensitivity to wormwood pollen in these patients was confirmed by intradermal tests and provocation tests which were examined on eye, nose and bronchus. The most of the patients were also sensitive to grass pollen and the symptoms were occured not only in the beginning of autumn, but in the beginning of summer. However, the patients of typical Ezo-Yomogi pollinosis were seen late in summer. From the results of intradermal tests with the pollen extracts of wormwood (Art. absinthium) and Ezo-Yomogi (Art. montana) in these patients, the threshold (end point of antigen dilution) values of skin reactions with both extracts were same value in each patient. The authers consider that Ezo-Yomogi pollen play a dominant role for the development of clinical manifestations in the patients.
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湯本 東吉, 御鍵 [ヨシ]治, 永松 典之, 高山 宏世, 加納 英美
原稿種別: 本文
1969 年 18 巻 12 号 p.
991-1004,1048
発行日: 1969/12/30
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Light and electron microscopic studies of the local graft versus host reaction (GVHR) in the kidney which inoculated donor spleen cells in subcapsular spaces of F1 hybrid rats were carried out. The animals were sacrified 15 hours, 3, 5, 7, 14, 28, and 35 days after the subcapsular injection. 1. The most prominent reactions were observed in 7 days after the subcapsular injection and they showed cytologically distinctive cellular infiltration. The changes of renal weight coincide with course of lesions. 2. Early stage of the local GVHR consisted of mainly lymphocytes of large or medium sizes and large pyroninophilic cells. Large pyroninophilic cells possess characteristic appearance by light and electron microscope. After 14th days reactions there were seen presence of plasma cells and lymphocytes. Morphological transformation between large pyroninophilic cells and plasma cells was light and electron microscopically noted. 3. Extensive invasion and destruction of the renal parenchyma were found from 7 to 14 days after the injection. Complete repair of renal parenchyma were seen parallel with disappearance of cell infiltration by local GVHR after 30 days the injection. 4. One may justly say that proliferation cells in early stage of local GVHR derived from donor cells. This reactions is considered to represent method of study of immunologically competent cells. 5. Morphological differentiation and origin of immunologically competent cells were discussed.
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木村 利定, 戸所 正雄, 黒梅 恭芳, 舘野 幸司, 松村 龍雄
原稿種別: 本文
1969 年 18 巻 12 号 p.
1005-1016,1049
発行日: 1969/12/30
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In the previous paper, authors reported that rice pollen was considered as one of the important inhalant allergens to cause asthmatic attacks in early fall in Japan. However, a problem remains to be solved as to whether hypersensitivity to rice pollen can be produced by the exposure to rice pollen itself or to other grass pollens which presumably cross react with it and are grown or cultivated widely in Japan. In the present paper, cross antigenicity was examined by means of passive transfer-in vivo and -in vitro neutralization test as well as in vitro neutralization test by using PCA reaction in monkey and guinea pig, between rice pollen and other grass pollens including wheat, orchard grass, timothy, corn and pumpus grass pollens. As result, it was demonstrated that weak cross antigenicity exists between rice pollen and pollens of wheat, orchard grass and timothy, but none between rice pollen and corn pollen as well as pumpus grass pollen. From these results, it seems reasonable to conclude that hypersensitivity to rice pollen foud in asthmatic children could be attributable mainly to rice pollen itself which floats abundantly from late summer to early fall in Japan.
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中川 圭一, 可部 順三郎, 三島 健, 宮本 昭正, 館野 幸司, 川上 保雄, 岩波 文門, 北原 暢乃, 笠井 和, 村野 順三, 飯 ...
原稿種別: 本文
1969 年 18 巻 12 号 p.
1017-
発行日: 1969/12/30
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浅野 秀二, 村野 順三, 飯倉 洋治, 塩田 浩政, 三島 健, 松村 竜雄, 館野 幸司, 岩波 文門, 北原 暢乃, 福山 幸夫, 笠 ...
原稿種別: 本文
1969 年 18 巻 12 号 p.
1017-1026
発行日: 1969/12/30
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中沢 浩亮
原稿種別: 本文
1969 年 18 巻 12 号 p.
1027-
発行日: 1969/12/30
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木村 武, 河合 健
原稿種別: 本文
1969 年 18 巻 12 号 p.
1027-
発行日: 1969/12/30
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島袋 良夫, 今西 耕一, 国枝 武幸, 後藤 晋, 吉田 敏久, 前田 克孝, 小黒 由里子, 小野 充, 桑原 紘一郎
原稿種別: 本文
1969 年 18 巻 12 号 p.
1027-1029
発行日: 1969/12/30
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宮本 昭正, 降矢 和夫, 水野 勝之
原稿種別: 本文
1969 年 18 巻 12 号 p.
1029-1030
発行日: 1969/12/30
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可部 順三郎, 中川 圭一
原稿種別: 本文
1969 年 18 巻 12 号 p.
1030-1033
発行日: 1969/12/30
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小林 登, 高島 宏哉, 河野 睦明, 春名 英彦, 早川 浩, 十字 文子, 菊地 郁子
原稿種別: 本文
1969 年 18 巻 12 号 p.
1033-1035
発行日: 1969/12/30
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舘野 幸司, 戸所 正雄, 中島 茂樹
原稿種別: 本文
1969 年 18 巻 12 号 p.
1035-1038
発行日: 1969/12/30
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岩波 文門, 北原 暢乃
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1969 年 18 巻 12 号 p.
1038-1039
発行日: 1969/12/30
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笠井 和, 熊谷 貴代
原稿種別: 本文
1969 年 18 巻 12 号 p.
1040-1041
発行日: 1969/12/30
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塩田 浩政, 三島 健, 田中 富美子
原稿種別: 本文
1969 年 18 巻 12 号 p.
1042-1043
発行日: 1969/12/30
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村野 順三, 飯倉 洋治
原稿種別: 本文
1969 年 18 巻 12 号 p.
1043-1045
発行日: 1969/12/30
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原稿種別: 文献目録等
1969 年 18 巻 12 号 p.
1046-1049
発行日: 1969/12/30
公開日: 2017/02/10
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原稿種別: 目次
1969 年 18 巻 12 号 p.
1050-1055
発行日: 1969/12/30
公開日: 2017/02/10
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