As the Presidential Address before the Autumnal Congress of the Japanese Pediatric Society in 1968, the results on, food allergy research studied in the Department of Pediatrics, Gunma University School of Medicine, were reported as follows. Although little has been known about food allergy in breast fed infants, authors have observed food allergy symptoms in almost all of them, demonstrating transfer of food allergen, food antibody and antigen-antibody complex from the mother to breast milk. Through eliminating these food allergens, infants could take solid foods safely without getting sensitized to them. By applying BDB haemagglutination test, food antibody, for example, against egg white could be measured in the amniotic fluid in high titers. It was assumed to belong mainly to the class of IgM, because it was 2 mercaptoethanol sensitive and could absorb anti-IgM activity from anti-IgM serum. From these it could be concluded that foetus could be actively sensitized against food transfered through the placenta from the mother. In the end, results on food allergen detection and elimination diets were described on the following diseases; infantile urticaria, acetonemic vomiting, abdominal epilepsy, allergic epilepsy, orthostatic albuminuria and nephrotic syndrome.

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As a special lecture before the Autumnal Congress of the Japanese Pediatric Society in 1968 the recent advance in diagnosis and treatment of food allergy in the Department of Pediatrics, Gunma University School of Medicine were described as follows: l) Almost all of the food allergy involved in childhood belongs to the category, of cyclic food allergy first named by Rinkel. As a result, diagnosis of food allergy should not be limited to the Goldman's criteria. 2) In severe cases in which offending food was extremely multiple, patients were initially instructed to remain on the highly restricted diet which was only composed of either rice or wheat as a cereal grain, several vegetables and seaweeds. Following the relief of symptoms, a test food was added one by one, observing closely as to whether or not food allergy symptoms were elicited. In milder cases, on the other hand, in which causative food limited to several ones, standardized elimination diets were usually employed to be free from anyone of milk, egg, soybean, meats and/or fishes. In Japanese children, those of milk, egg and soybean represent a most important food allergen to which allergy most often arises. 3) To the patient hypersensitive to both of cereal grains as rice and wheat which have been usually taken in Japanese barley, oats, millet, italian millet, and tapioca were used. 4) Our experience emphasized the importance of keeping a patient on the prescribed elimination diets for at least 3 weeks and often more longer in order to detect food allergens involved. 5) New common foods were produced to be available for maintaining elimination diets. At first, bread, biscuit and cream completely excluded from the milk products were prepared. Second, as a substitute for soybean sauce, which was richly consumed daily as a condiment in Japan, wheat sauce was newly produced. Above-mentioned products were ascertained by PCA test to be strictly devoid of the individual food allergen. 6) Common foods daily used as dry fish and goods, cane food, and coase confectionary were PCA tested to confirm whether or not these foods were completely absent of milk, egg, and soybean. One fourth of common foods tested resulted in positive responses against above-mentioned three antigens, indicating the inadequateness of these foods to use in maintaining the milk, egg, and soybean-free elimination diet.

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According to the histories of the patients with bronchial asthma the factors involved in the occurrence of asthmatic attack were investigated and the following results were obtained. 1. Analysis of the season and occurrence of asthematic attack studied on 237 cases revealed that 55 had the attack in autumn, 52 regardless of the season, 31 in winter and 25 in both spring and autumn. 2. Of 685 asthmatics, the causes of the first asthmatic attack were presumed in 464 cases. They were common cold occurred in 245 cases, revealing the highest incidence, inhalation of sea-squirt substances in 80, pneumonia in 22, acute bronchitis in 17, fatigue in 14, cold and pregnancy in 11 each. Of 673 asthmatics, the causes or the inducing factors of asthmatic attack after the onset of bronchial asthma were presumed in 567 cases. They were related to: 1) physical conditions in 352 (common cold and influenza in 229, fatigue in 126, overeating in 34, psychic tension in 24, bathing in 19, etc.);. 2) weather in 222 (cold in 84, rainy day in 63, cloudy day in 33, sudden change in weather in 29, humid day in 21, etc.); 3) dust in 173 (sea-squirt substances in 83, house dust in 78, cotton wool in 9, etc.); 4) smoke and offensive odor in 91 (cigarette smoke in 38, smoke of mosquito stick and smoke of broiling fish in 9 each.) 5) food and drink in 79 (wine in 30, vegetable foods in 26, animal foods in 20, fatty foods in 9, etc.) ; 6) drugs in 9 (ACTH in 3, aspirin in 2, etc.) ; 7) animals in 6 (contact with domestic. animals in 4, furs and feathers in 2) ; 8) plants in 5 (newly-bult house in 3, pollen in 2); 9) molds in 5 (aspergillus in 2, other molds in 3). 3. The causes or the inducing factors of asthmatic attack above mentioned were studied as follows: l) those relating to the psychic and physical conditions were investigated from the view-point of the autonomic nervous function and the endocrine glands; 2) those relating to the infection of the upper respiratory tract were investigated from the view-point of bacterial allergy; 3) those relating to the inhalants and ingestants were investigated by the skin test with these substances; and the significant results were obtained from each of them. 4. The incidence rate of positive reaction in the intradermal test was 51.2% with house dust antigen, 41.8% with Paspat, 21.6% with ragweed pollen antigen, 15.5% with the mixed antigen of crab, lobster and oyster, 15.5% with sea-squirt antigen (except sea-squirt asthma patients), 11.8% with mixed antigen of cat hair and dog hair, 11.2% with yam antigen.

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In recent years, basophilic leucocytes have come to be much interested in allergic diseases. Shelley et al., obserbed basophilic degranulation at antigen-antibody reaction and reported the morphologic changes in details. Counting of basophilic leucocytes and eosinophilic ones was made and it was compared with that of normals. With eosinophilic leucocytes, prominent difference between allergic patients and normals was admitted. But it was not admitted with basophilic leucocytes. Similarly, correlation between counted basophilic leucocytes and eosinophilic ones was not seen. Provocation to nasal mucosa did not show any change of counted basophilic leucocytes. Therefore, it is difficult to use the counting of basophilic leucocytes as a diagnostic method of nasal allergy.

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It has been well known that bronchial asthmatic patient has bronchial hypersensitivity to histamine or acetylcholine. However, there are little report on the correlation between the hypersensitivity and allergic sensitization or asthma attack itself. In order to know these correlations an attempt was made, the observation of fluctuation of the hypersensitivity during the sensitization or asthmatic attack or desensitization by inhalation of the allergen in experimental guinea pig asthma. It was not observed that the significant correlation between the hypersensitivity and the other allergic process. These results suggest that the bronchial hypersensitivity to histamine or acetylcholine might be builded up independently to the immunological process.

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1. Human hemolytic complement activity was measured by Mayer's CH_<50> method in human sera obtained from 854 healthy Japanese children and adults. The result indicated that mean value of CH_<50> was 35.8 units per milliliter (29.2-43.9 units per ml. with 1 σ). No serum was found showing more than 90 CH_<50> units/ml., though accurate titration was not performed in the sera with higher titer than 60 CH_<50> units /ml. Eleven out of 854 sera showed markedly low hemolytic complement activity of less than 2 CH_<50> units /ml. It was already reported by the author and others that some of these sera were deficient in the third component of complement (C_3). 2. While investigating the averages of CH_<50> in each age from six to sixty, it was noticed that CH_<50> increased in the ages of ten, eleven and twelve. However, no correlation between complement titer and sex or blood type was found. 3. The variation of CH_<50> during daytime was observed in 13 healthy volunteers and 12 patients with such diseases that were considered to have no influence upon serum complement level. The determination for CH_<50> in these subjects was made six times a day from 7 a.m. to 9 p.m. The results revealed that no significant difference between maximum and minimum values of diurnal variation was found in CH_<50> of each case.

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In the eastern bank area of the Abe River flowing through Shizuoka City, there flourishes the wooden wares industry manufacturing ready timber, furniture, stereo-cabinets, orgel music boxes, geta clogs, etc. Among the craftsmen engaging in such occupations, the symptoms of inhalative asthma supposed to be caused by many kinds of lumber are often found. And in this report, accordingly, a case with bronchial asthma is stated, who was lately treated and observed, and finally concluded to be caused by mulberry lumber. Y.F., a lumber processor, 27 years of age, took employment in wooden wares industry 10 years ago. And these 8 years he has stuck mulberry board to the surface of chests of drawers to finish it with elaborate grain. The asthmatic attacks have frequently occured in the later 4 years without any connection with diet. On the first day when he visited our clinic, a slight peripheral leucocytic eosinophilia was observed. The intracutaneous test with kinds of the inhalatory allergen extracts was carried out, and consequently positive reaction to house dust and cat's tail pollen (typha angustata) was proved. The hyposensitization therapy with these allergen extracts was not complacently successful, but asthmatic attacks still occured ever after the work using mulberry board. Accordingly, the intracutaneous test, Prausnitz-Kustner's passive transfer test and the inhalative provocation test with self-prepared extract of mulberry lumber were carried out and consequently positive reactions were acquired by them. And the hyposensitization therapy with mulberry lumber extract, in addition to house dust and cat's tail pollen extracts, was performed with satisfaction. Judging from the above-mentioned clinical history and the results of allergic investigations, this case is considered to be the subject with occupational allergic asthma caused by mulberry lumber.

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Three experiments were employed for analysis of polygraph pattern in provoked asthma. First experiment was "experimental expiratory dyspnea" (using the mask with expiratory air way and inspiratory air way; the former is narrower than the latter). Second experiment was "rebreathing in Douglas bag" corresponding to increasing Pco_2 in serum. Third experiment was "inflating a baloon" corresponding to forced expiration. Third experiment reveals most of same patterns as polygram in provoked asthma reveals in these experiments and 1st experiment reveals least of them. These results suggest that provoked asthma is chiefly composed of two components, forced expiration and resistive expiration. As a whole, polygram in provoked asthma suggests sympathecotonia of circulating system of blood. Decrease of pathological findings of polygram precedes by improvement of symptom after treatment. Analysis of provocation on same patient in different season suggests that one of the precipitating factor is season and dysfunction of autonomic nervous system. Asthma attack as well as provoked attack was discussed by analysis of polygram in provoked asthma.

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