アレルギー
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
18 巻, 9 号
選択された号の論文の9件中1~9を表示しています
  • 原稿種別: 目次
    1969 年 18 巻 9 号 p. 1050-1055
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 山名 征三
    原稿種別: 本文
    1969 年 18 巻 9 号 p. 731-741,797
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
    Anti-mouse thymocyte rabbit serum (ATRS), anti-lymphnode cell rabbit serum (ALRS) and anti-spleen cell rabbit serum (ASRS) were prepared, and comparative studies of the immune potency of these three anti-lymphocyte serum (ALS) were performed. Cytotoxic effect and leukoagglutination of ALS were observed by the new tissue culture technique. Each anti-serum unselectively destroyed thymocytes, lymphnode cells and spleen cells in vitro. Its potency decreased in the order of ALRS, ASRS and ATRS. The effect on the prolongation of the mean survival time of skin allograft was most prominent with ATRS. The grafted skins in the group of mice given ATRS which had the lowest antibody titer in vitro lived for 72.0 days on the average, and those given ALRS for 22.5 days and ASRS for 17.0 days respectively. A specific precipitating line was observed between ATRS and thymic abstractive fluid. It was supposed that the excellent inhibiting effects of ATRS on the homograft rejection might depend on the antagonistic action to the humoral factor derived from the thymus tissue.
  • 山名 征三
    原稿種別: 本文
    1969 年 18 巻 9 号 p. 742-757,797
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
    The mode of action of the anti-lymphocyte rabbit serum (ALS) was studied by the fluorescent antibody technique. In vivo tissue localization of ALS was observed by fluorescent microscope after the single injection of ALS conjugated with FITC. In vitro reactivity of the conjugated anti-serum with the frozen sections or impregnant preparations of mouse lymphoid tissues were also studied. After intravenous injection into mice, ALS accumulated mainly in the lymphoid organs. Deposition of the conjugated ALS which probably represented antigen-antibldy complex was observed in the glomeruli after repeated injection of ALS. In vitro preparations, the conjugated anti-serum stained lymphocytes specifically. Plasma cells proliferated in the lymphoid tissue of the mice received the repeated injection of ALS showed cytoplasmic fluorescence that was indicative of the production of the antibody against ALS. These findings suggested that the immunological unresponsiveness of the mouse injected with ALS was due to the block of the biological activity of lymphoid cells as a result of the antigen-antibody reaction. Following these experimental data, author proposed the new hypotheses of "partial immune tolerance theory" as the mode of action of ALS.
  • 遠藤 晃市
    原稿種別: 本文
    1969 年 18 巻 9 号 p. 758-771,798
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
    The enhancing effect of sodium succinate on in vitro anaphylactic histamine release from guinea-pig lung has been reported. Succinate also enhanced evidently the anaphylactic contraction of guinea-pig ileum as well as the degranulation of mast cells in the mesentery produced by the rabbit anti-guinea pig serum in vitro. Further, a systemic injection of succinate aggravated the cutaneous edema elicited by the intracutaneous injection of anti-serum. These effects of succinate seem to be specific to the antigen-antibody reactions in guinea pigs since all these reactions in rats were not effected except that oxygen uptake in the rat lung tissue was increased as in the guinea pig. Similar reactions induced by compound 48/80 or histamine were not enhanced in guinea pigs. Alpha-ketoglutarate and malate among other intermediates of Krebs cycle, and glucose showed a slight increasing effect on the anaphylactic histamine release from guinea-pig lung, but not in oxygen uptake. Maleate which is not an energy-yielding substrate had and effect enhancing all these antigen-antibody reactions in guinea pigs, but not in rats, in similar fashion to succinate; however, maleate did not increase oxygen uptake. The anaphylactic histamine release and oxygen uptake were both inhibited by the metabolic inhibitors such as cyanide, 2, 4-dinitro-phenol and iodoacetate either in the presence or absence of succinate. Malonate was an effective inhibitor of all these antigen-antibody reactions which were enhanced by succinate and also by maleate. Succinate did not accelerate the desensitization. These observations provide some obstacles to accept the interpretation which attributes the succinate effect on the antigen-antibody reactions simply to ints energy-enharnessing metabolic effect on the basis of energy-requiring processes in anaphylactic histamine release. Succinate may act on the step after the union of antigen and antibody but not on the step being displayed by released chemical mediators.
  • 堀口 申作, 長谷川 誠
    原稿種別: 本文
    1969 年 18 巻 9 号 p. 772-774,798
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
    With regard to the quantitative study of nasal sensitivity of nasal allergic patients, the authors previously reported on its details. Nasal allergic patients treated with nasopharynx or desensitization therapy usually progressed favourably in 3 to 6 months. Between the nasal sensitivity to histamine solution and the progress of nasal allergy, some close relation seems to exist. At the beginning of the treatment, their nasal sensitivity to histamine was approximately high but after the treatment of 3 to 6 months the sensitivity changed to low. This fact means that the histamine sensitivity test is useful for the diagnosis of nasal allergy.
  • 伊藤 暢英
    原稿種別: 本文
    1969 年 18 巻 9 号 p. 775-791,799
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
    Previous reports indicated that the antihemolytic titers (ACLθ) of the sera against the hemolysin (θ-toxin) of Clostridium perfringens showed marked high levels in some patients with hepatic or renal disorder, and some definite lesions could be induced in the liver and the kidney of the animals immunized with Clostridium perfringens. In the present work, from Todd suggesting that Streptolysin O is similar to Clostolysin θ in its biological and biochemical characters, Author studied whether there were a cross-reactivity between Clostridium perfringens and Streptococcus hemolyticus, sensitizing rabbits by bacilli individually, and studied the affinity of each bacilli with some tissues. Further it was studied the cross-reactivity of the cell components of Clostridium perfringens with hepatic or renal tissues. 1) It was conceivable that there is a cross-reactivity between Streptolysin O and Clostolysin θ. 2) In the groups immunized with Cl.perf., some lesions similar to glomerulitis and hepatitis were observed, and in the groups immunized with Streptococci, some lesions similar to glomerulitis and less lesion of heart were observed. Renal lesion of the former was more remarkable than that of the latter. In fluorescent antibody technique, the specific stainings were found at the liver and the kidney by the anticlostridium sera, and at the kidney and the heart by the antistreptococcal sera. 3) In rabbits sensitized with the supernatant of disrupted Cl.perf., it was observed the marked lesions of glomerulitis and hepatitis. It was particularly to mention that marked granulomatous lesions similar to sarcoidosis were founded in the lung. 4) It was observed that in the fluorescent antibody technique, agar gel diffusion test and sensitized hemagglutination test, the anti-sera against the supernatant of disrupted Cl.perf. reacted with the liver and the kidney.
  • 宮本 昭正, 可部 順三郎, 村中 正治
    原稿種別: 本文
    1969 年 18 巻 9 号 p. 792-796,799
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
    Disodium cromoglicate was inhaled by 15 asthmatic patients 30 minutes prior to inhalation provocation tests with causative antigens. One second forced expiratory volumes(FEV_1) were determined prior to, 5 minutes, 10 minutes, 15 minutes after inhalation of antigens respectively. Identical studies were carried out after inhalation of Placebo instead of disodium cromoglicate. The maximum reduction of FEV_1 were compared between them. Suppressive effect of disodium cromoglicate was proved in 14 out 15 cases.
  • 原稿種別: 文献目録等
    1969 年 18 巻 9 号 p. 797-799
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
  • 原稿種別: 付録等
    1969 年 18 巻 9 号 p. 800-
    発行日: 1969/09/30
    公開日: 2017/02/10
    ジャーナル フリー
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