Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
Volume 22, Issue 7
Displaying 1-12 of 12 articles from this issue
  • Article type: Cover
    1973 Volume 22 Issue 7 Pages Cover37-
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Article type: Cover
    1973 Volume 22 Issue 7 Pages Cover38-
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (47K)
  • Article type: Bibliography
    1973 Volume 22 Issue 7 Pages Misc9-
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
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  • Kenichiro Kinoshita
    Article type: Article
    1973 Volume 22 Issue 7 Pages 453-465,501
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The purpose of this study is to investigate the relationship between the humoral antibody, (ASLO titre in the serum) and cell-mediated immunity, (SLO-induced blasttransformation of peripheral blood lymphocytes) in streptococcal infection, acute nephritis and rheumatic fever. Thirty four cases of normal subjects and 54 cases of various diseases above mentioned were examined. The following results were observed. 1) In 34 normal subjects, the per cent of blast cells was ranged from 1% to 27% (9.0 ± 6.4, mean ± S.D.) 2) In 55 patients with high ASLO level in their sera, the percent of blast cells was ranged from 0.2% to 46.8% (11.2± 11.8, mean ± S.D.) The difference of blasttransformation of two groups between normal subjects and patients with high ASLO level, was not statistically significant. 3) No correlation between ASLO titre and SLO-induced blasttransformation in the patients with high ASLO level was observed. 4) But, when observed from initial stage of above mentioned diseases, it was found that ASLO titre was promptly increased at first, SLO-induced blasttransformation was elevated later and maximum response to SLO was observed in 2 months to 3 months after streptococcal infection. 5) So, the response to SLO in the patients following 1 to 3 months after streptococcal infection was significantly higher than normal subjects. 6) The maximum response to SLO in the patients who showed very high ASLO titre at initial stage which is considered as severe infection was higher than patients with mild infection. 7) The blastgenic activity of SLO was found in non-hemolytic fraction because SLO showing no hemolytic activity by oxidized and SLO-ASLO complex showing no hemolytic activity induced blastgenesis.
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  • Shigeo Uematsu
    Article type: Article
    1973 Volume 22 Issue 7 Pages 466-485,501-50
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The characteristics of photoallergy lies in the antigen formation process where light is playing some role. 3, 3', 4', 5-tetrachlorosalicylanilide (T_4CSA) has been known as one of the most potent photocontact allergens. The author studied on the photoconjugation of T_4CSA and proteins in vivo as well as in vitro system to clarify the fundamental mechanisms of the photoantigen formation. The results were as followes; 1) On thin layer chromatography at least 4 new spots of photoproducts of T_4CSA by ultraviolet ray (UV) irradiation (320-400 nm) were recognized, two of which were identified as 3', 4', 5-T_3CSA and 3', 4-DCSA from the Rf values respectively. 2) T_4CSA could combine with prealbumin, albumin and α_1globulin fraction of human serum protein by UV irradiation in vitro. It made the photoconjugate in vivo with the fraction of the guinea pig epidermal soluble protein which corresponded electrophoretically to α_1globulin of human serum. 3) The mole ratio of T_4CSA to HSA composing the photoconjugate was 1.8: 1.0. 4) The binding force of T_4CSA-HSA photoconjugate was so strong that it could not be dissociated by guanidine・HCI treatment. 5) Effects of pH and temperature on the amount of the photoconjugate in vitro suggested that the combination might be influenced not only by the conditions of T_4CSA but by that of protein. 6) To form the photoconjugate of T_4CSA and protein, they should coexist when they were irradiated. 7) After photoconjugation the fluorescence of T_4CSA-HSA photoconjugate decaied without dissociation by UV irradiation. It suggested that T_4CSA bound with HSA could lose halogen molecules by irradiation. 8) Antigen for sensitization was prepared by irradiation to the mixture of guinea pig epidermis homogenate and T_4CSA. Some of the guinea pigs which were sensitized by the injection of the antigen could show positive allergic reaction by the challenge of T_4CSA application followed by UV irradiation.
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  • Masaharu Muranaka, Koyo Takeda, Shuji Suzuki, Hiroshi Okumura, Hiroshi ...
    Article type: Article
    1973 Volume 22 Issue 7 Pages 486-493,502
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Bronchial sensitivity to acetylcholine was measured on subjects selected from three groups, i.e. Group A: asthmatic subjects whose asthma had ceased three years or more before testing, Group B: asthmatic subjects having asthma attack currently, Group C: non-atopic normal subjects. Sensitivity of bronchi to inhaled acetylcholine was quantitatively presented as the "respiratory threshold for acetylcholine": the minimal amount of the inhaled agent which causes the initial decrease of FEV_<1.0> greater than 10 per cent from standard. IgE concentration and IgE antibody titer to mite allergen in the sera of the subjects were also determined. Following results were obtained: 1. IgE antibody titers to mite allergen were clearly elevated in Group A or in Group B as compared with low titer in Group C (p<0.01), but no difference was found statistically between Group A and Group B. 2. Serum IgE concentration ranged 10-2250 unit/ml in Group A, 10-3400 unit/ml in Group B and 10-600 unit/ml in Group C, respectively. 3. Twelve (60 per cent) from 20 cases of Group A showed low bronchial responsiveness to inhaled acetylcholine and four cases responding intensely to the agent, whereas Group B contained a large proportion who reacted moderately or markedly. Three of four cases in Group A who responded intensely to acetylcholine revealed the low concentration of IgE. No significant correlation between the respiratory threshold for acetylcholine and IgE concentration of sera was obtained. These findings suggest that the bronchial sensitivity is important factor for asthmatic attack, though serum concentration of IgE might be another important factor.
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  • Satoru Takayama, Kensuke Watanabe, Yozo Saito, Makoto Hasegawa
    Article type: Article
    1973 Volume 22 Issue 7 Pages 494-500,503
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The IgE concentrations of 125 sera with allergic rhinitis were measured by a single radial immunodiffusion. The correlation between serum IgE concentrations and some routine allergy tests was studied. Several diagnostic benefits at allergy practice were obtained from the measurement of serum IgE levels. 1) A case with known allergens, positive atopic histories and the raised IgE level indicates marked immunological abnormalities. 2) In a case with unknown allergens, negative atopic histories and the raised IgE level, histories and skin tests must be rechecked, parasitic infections are necessary to be ruled out. 3) In a case with only one positive allergen on intracutaneous tests and the raised IgE level, there is a possibility that the specific IgE antibody against the positive allergen is present in blood. 4) In a case with positive provocation tests and the raised IgE level, the positive allergen is considered to be a true allergen. Nevertheless the measurement of serum IgE concentrations is thought of not contributing to a direct advantage to the diagnosis and therapy of nasal allergy.
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  • Article type: Bibliography
    1973 Volume 22 Issue 7 Pages 501-503
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1973 Volume 22 Issue 7 Pages 504-
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1973 Volume 22 Issue 7 Pages 505-507
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
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  • Article type: Cover
    1973 Volume 22 Issue 7 Pages Cover39-
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (31K)
  • Article type: Cover
    1973 Volume 22 Issue 7 Pages Cover40-
    Published: July 30, 1973
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (31K)
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