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Article type: Cover
1975 Volume 24 Issue 5 Pages
Cover29-
Published: May 30, 1975
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Article type: Cover
1975 Volume 24 Issue 5 Pages
Cover30-
Published: May 30, 1975
Released on J-STAGE: February 10, 2017
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Article type: Bibliography
1975 Volume 24 Issue 5 Pages
Misc7-
Published: May 30, 1975
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Morio Sudo
Article type: Article
1975 Volume 24 Issue 5 Pages
405-414,458
Published: May 30, 1975
Released on J-STAGE: February 10, 2017
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Clinical findings in 27 autopsy cases of bronchial asthma and 4 cases changed into emphysema were investigated. The causes of death in patients with bronchial asthma were classified into 3 groups: the 1st group consisted of 19 cases of death during attack (suffocation 12, accident 3, complication 4), the 2nd group 18 cases died without paroxysm, the 3rd group 4 cases changed asthma for emphysema. The mean survival age was 47.2 years, and the average period from onset of illness to death was 19.1 years. The servival age and the period from the onset of illness to death were shortened in the cases of suffocation, accident and severe paroxysmal type. Emphysema, allergic disease, and respiratory infection were sometimes complicated. The causes of fetal asthma attack were infection, unappropriate hyposensitization therapy and reduction of removal of corticosteroids. Death due to suffocation is of two ways. The one occurred after prolonged status asthmatics in 5 cases, and the other occurred suddenly in 7 cases. In clinical examination the lung function and urinary 17 OHCS excretion showed to decrease, but electroncardiogram during period without paroxysm did not show cor pulmonale. Steriod hormone were administrated in 23 of 27 cases. Eleven cases of severe chronic asthma depending on steroid hormones were defined intractable asthma.
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Morio Sudo
Article type: Article
1975 Volume 24 Issue 5 Pages
415-424,458-45
Published: May 30, 1975
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Pathological finding in 27 autopsy cases of bronchial asthma and 4 cases changed into emphysema were investigated. The pathological findings in the asthma lungs were as follows: 1) Broncho-constriction (hypertrophy of smooth muscle, fold-like prominence of mucous membrane, and narrowing of lumina), 2) mucous hypersecretion (hypertrophy of mucous gland and goblet cell-like formation of bronchial epithelium), 3) cellular response of bronchial wall (infiltration of eosinophil, plasma cells, lymphocytes, and decrease in number and degranulation of mast cell), 4) edema and thickening of bronchial wall, 5) thickening of basement membrane, 6) distended lungs. The real pathological manifestation was shown by 1) and 2) above mentioned, and the pathological triad of 1), 2) and 3) was decided. These findings were most complete and prominent in the cases of death during attack, especially suffocation. When emphysema was dominant, hypertrophy of the right heart was found. The adrenal atrophy was dominant in order of the severity of asthma, the hypofunction of adrenal cortex, and the amount of steroids administered. The adrenal atrophy was most prominent in severe chronic asthma (intractable asthma).
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Shigeru Arimori, Yukinobu Ichikawa, Yasunari Nakata, Shinya Tada, Hide ...
Article type: Article
1975 Volume 24 Issue 5 Pages
425-432,459
Published: May 30, 1975
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The membranes of sarcoplasmic reticulum (SR) and transverse tubule system (T-system) were isolated from rat muscle homogenate using the centrifugation with sucrose linear density gradient. Mice given these membrane fractions subcutaneously with or without FCA developed moderate myositic changes such as muscle fiber degenuration, muscle fiber atrophy, central nuclei, chain nuclei and phagocyte infiltrations. Histochemical analysis of succinic dehydrogenase demonstrated remarkable atrophy of type I fibers than type II fibers. These changes were more prominent in mice immunized with these fractions with FCA than without FCA. Humoral antibodies against these fractions were observed by the immunofluorescence method and micro-Ouchterlony gel diffusion method. Myopathic low amplitude voltages appeared on the electromyogram of these immunized mice. The waning phenomenon was induced in mice immunized with SR fraction by supramaximal repetitive stimulations. The thymus was hyperplastic with enlarged lymphnodes, although thymitis was not clear histologically.
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Hirotaka Shinoda, Eisuke Kojima, Kazumi Kanda, Masahiro Kasai, Tsutomu ...
Article type: Article
1975 Volume 24 Issue 5 Pages
433-436,459
Published: May 30, 1975
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Effect of N-benzenesulfonyl-β-alanine hydrazide (KH-125) on antibody production in mice was examined by Cunningham and Szenberg's plaque technique. 1. KH-125 dose-dependently suppressed the appearances of 19S and 7S plaque-forming cells (PFC) both in intraperitoneal and oral administrations. 2. The maximum suppression of the appearance of 19S PFC occurred when KH-125 was given at 48 hours after antigen injection. Side effects of KH-125 are now in progress.
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Hirotaka Shinoda, Eisuke Kojima, Kazumi Kanda, Tsutomu Irikura
Article type: Article
1975 Volume 24 Issue 5 Pages
437-442,460
Published: May 30, 1975
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Effect of N-benzenesulfonyl-β-alanine hydrazide (KH-125) on adjuvant arthritis was compared with that of 6-mercaptopurine (6-MP). 1. In the prophylactic experiment on adjuvant arthritis, KH-125 and 6-MP suppressed swelling in adjuvant injected and noninjected feet and also increase in arthritis score. KH-125 was considered to be 3 times safer than 6-MP. 2. KH-125 was also effective on the established arthritis. 3. Rebound of foot swelling occurring after withdrawal of KH-125 was not prominent.
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Mitsuo Oishi, Akihiko Yoshida, Sumio Morishita, Michiya Yamaguchi, Min ...
Article type: Article
1975 Volume 24 Issue 5 Pages
443-447,460
Published: May 30, 1975
Released on J-STAGE: February 10, 2017
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Two cases (21-year-old and 24-year-old male) of flour asthma of the employees working in the same confectionary company were reported. 1) In the first case the attacks of asthma following the onset of nasal and eye symptoms were observed after engagement in the confectionary work for two years and eight months. In the second case the attacks of asthma following the urticaria were observed after engagement in the work for five years and six months. In both patients the attacks of asthma were induced almost only in the factory. 2) The results of the clinical examinations in both cases showed slight increase of eosinophils in the blood and serum IgE concentration. Skin tests by flour, gluten and glutenin containing in flour were all positive. PK reaction, provocation test and conjunctival reaction by gluten and glutenin containing in flour were also positive. The types of the reactions were all immediate type. Agar diffusion precipitation test by Ouchterlony was negative. 3) From these results it was suggested that the antigens in these two cases might be gluten and glutenin. These cases might be allergic bronchial asthma belonging to type 1 allergy classified by Coombs and Gell.
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Terumasa Miyamoto, Kenji Mano, Yutaka Morita, Korichiro Kudo, Yasuyuki ...
Article type: Article
1975 Volume 24 Issue 5 Pages
448-454,461
Published: May 30, 1975
Released on J-STAGE: February 10, 2017
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Thirteen inhalants (mite, house dust, silk, 6 pollens, 3 molds and dog and cat danders) and 6 foods (egg york, egg white, shrimp, oyster, crab, mackerel) were chosen and paper disc method was employed to study the correlation between the scratch test and RAST. High correlation was found between the end point of scratch test and the isotope counts of RAST in mite, house dust, silk and grasses, but was not so high in molds, ragweed and cedar. Positive RAST correlated well with positive allergic history in animal danders and foods. When the end point of scratch test was more than 1:10000, RAST was invariably positive. Whereas RAST was negative in all cases, in which scratch test was negative. No correlation was noted between house dust and book lice, cockroach or Aspergillus in RAST. From the cross neutralization of IgE antibodies between house dust and mite, it was further confirmed that the major allergenic component of house dust is mite.
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Hedehiro Kobashi, Shinya Tada, Yasunari Nakata, Kenji Koriyama, Yukino ...
Article type: Article
1975 Volume 24 Issue 5 Pages
455-457,461
Published: May 30, 1975
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The T- and B-lymphocyte subpopulations, and PHA-P or PWM reactive lymphocytes in the peripheral lymphocytes obtained from the patients with Sjogren's syndrome were examined simultaneously, comparing with those of the normal subjects. The sheep red cell rosette-formation was used as A-lymphocyte marker, and surface immunoglobulin as B-lymphocyte marker. The lymphocyte cultures were performed using PHA-P and PWM as mitogens and the ^3H-TdR incorporation rate was calculated from the per cent of cpm uptake in mitogen-added culture against mitogen-nonadded culture. No remarkable change of T-lymphocytes was obtained between Sjogren's syndrome and normal subjects, while the decrease of PHA-P reactive lymphocytes were observed in the Sjogern's syndrome (P<0.001). The increase of B-lymphocytes and the decrease of PWM reactive lymphocytes were observed in the patients with Sjogern's syndrome who have been histologically demonstrated the massive infiltrations of lymphocytes into the sublingual glands. The correlation between the T- and B-lymphocytes subpopulations and their functions in the circulnatig lymphocytes and in the tissue were discussed in the paper.
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Article type: Bibliography
1975 Volume 24 Issue 5 Pages
458-461
Published: May 30, 1975
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Article type: Appendix
1975 Volume 24 Issue 5 Pages
462-
Published: May 30, 1975
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Article type: Appendix
1975 Volume 24 Issue 5 Pages
463-
Published: May 30, 1975
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Article type: Cover
1975 Volume 24 Issue 5 Pages
Cover31-
Published: May 30, 1975
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Article type: Cover
1975 Volume 24 Issue 5 Pages
Cover32-
Published: May 30, 1975
Released on J-STAGE: February 10, 2017
JOURNAL
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