Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
Volume 24, Issue 9
Displaying 1-13 of 13 articles from this issue
  • Article type: Cover
    1975 Volume 24 Issue 9 Pages Cover45-
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Article type: Cover
    1975 Volume 24 Issue 9 Pages Cover46-
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (37K)
  • Article type: Bibliography
    1975 Volume 24 Issue 9 Pages Misc11-
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Minoru Okuda, Atsushi Usami, Tokuji Unno
    Article type: Article
    1975 Volume 24 Issue 9 Pages 643-649,688
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The concentrations of IgA antibodies to mite (Dermatophagoides farinae) in nasal fluids collected from the patients of mite nasal allergy were measured by means of the radioimmunoprecipitation method. These were expressed by the protein amount of allergen extract bounded by the antibodies in 1ml of the nasal fluids. The mean binding value was 4.2μg, which corresponded to 0.55mg of body weight of dried mites, and was the amount sufficient to participate in local immunity against mite inhaled and deposited on the surface of the nasal mucous membrane. However, the degrees of the nasal provocative reaction with mite extract were not correlated to the concentrations of antibodies determined in each patient. The above binding activities of nasal antibodies were detected not only in mite allergic patients but in non-mite allergic patients although the activity in the latter was only one third as much as the former. The binding activities were not changed after immunotherapy with mite or house dust allergen extract, and were not different between reduced and non-reduced nasal fluid in the same amount of IgA antibody. The ratio of nasal IgA antibody/serum IgA antibody was approximately 14.3 times greater than the ratio of nasal IgG antibody/serum IgG antibody, suggesting that local production of IgA antibody is greater in amount than that of IgG antibody.
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  • Sumiki Miyachi, Koji Ito, Sohei Makino, Takao Shida, Yutaka Morita, Te ...
    Article type: Article
    1975 Volume 24 Issue 9 Pages 650-655,688-68
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    A case of baker's asthma is reported. The history of his illness definitely indicated that he was allergic to the flour. Skin test and ophthalmic test were positive to flour-extract. In the patient's serum, anti-flour IgE antibody was proved employing the RAST (radioallergosorbent test) technique. After the protein portion to the extract was precipitated with TCA (trichloracetic acid), remaining supernatant was tested whether it still possessed antigenicity, which showed that this protein-free preparation still yielded erythema reaction on the patient's skin. These fact suggests that although the antigenicity of the extract lies mainly in the protein portion of the extract, other portion may also contribute to the antigenicity. After his serum was neutralized with gliadin or glutenin, the main components of the flour protein, RAST was performed employing flour-paper-discs. RAST was performed employing gliadin and glutenin-paper discs. These showed that the antigenicity of flour lies in both of these proteins. Hyposensitization therapy was continued for two and a half years, and clinical course of the patient was observed. No definite improvement was shown, although his state was best during the period while he left his factory. It is suggested that baker's asthma should be treated from an occupational and environmental point of view, and too much stress should not be put on the effectiveness of hyposensitization therapy.
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  • Aiko Umetsu, Shuzo Matsumoto, Akimasa Okuno, Junichi Kadowaki, Hiroshi ...
    Article type: Article
    1975 Volume 24 Issue 9 Pages 656-664,689
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The pituitary adrenocortical responses to insulin induced hypoglycemia were studied in 15 asthmatic children and 5 control ones. The asthmatics were the patients compelled to admission to the National Sanatorium, Nishi-Sapporo Hospital because of their resistance to the treatment. They were divided into two groups: group 1 consisted of 10 asymptomatic patients and group 2 of 5 symptomatic ones after their admission. In group 1, the decreased rate of the blood sugar levels at 30 minutes after the administration of insulin showed significantly lower values as compared with those in control at 7:30 a.m.. However, the plasma cortisol levels at 30 minutes after the administration of insulin were significantly higher than those before the administration of insulin, and the mean increased values were significantly higher than those in control. Therefore, in group 1 patients cortisol was found earlier and larger amount of it was secreted in plasma by the stimulation of insulin. In group 2, the decreased rate of the blood sugar levels at 30 minutes after the administration of insulin showed significantly lower values as compared with those in control at 7:30 a.m.. However the plasma cortisol levels were almost the same as those in control. Concerning the decreased rate of the blood sugar levels after the administration of insulin at 8:00 p.m., there were no defierences among group 1, group 2 and control. But in group 2 the total amount of the plasma cortisol secreted for 60 minutes at 8:00 p.m. was signigicatly lower than those at 7:30 a.m.. There was no correlation between the plasma cortisol levels before stimulation and the maximum increased dosis of plasma cortisol after insulin administration.
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  • Kenpu Amada, Tatsuo Matsumura, Takayoshi Kuroume
    Article type: Article
    1975 Volume 24 Issue 9 Pages 665-674,689-69
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Out of 24 milk allergy patients, 12 were proved to be lactose intolerant by the lactose load test. Of these, 10 showed symptoms, such as colic, abdominal distension and/or diarrhea, while two did not. Lactosuria was observed in only three of twelve. Provocative testing with milk protein using lactose-free milk, lactose-free casein or both was carried out on six patients with lactose intolerance. All six showed allergic reactions, indicating that milk protein allergy existed in addition to lactose intolerance. Thus, it seems likely that allergy to milk protein and lactose intolerance are closely related.
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  • Takahiko Kaji
    Article type: Article
    1975 Volume 24 Issue 9 Pages 675-680,690
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Lymphocytes were isolated from venous blood of patients or normal individuals by Conray-Ficoll density gradient. Zero point one ml of lymphocyte suspension adjusted to the concentration of 5×10^6 cells/ml was mixed with the equal volume of 0.5% sheep erythrocytes and incubated for 15 minutes at 37℃ and then for at 4℃ or O℃ under various conditions and the rate of rosette formation was compared among these conditions. Lymphocytes binding more than 3 sheep erythrocytes were considered to be positive. By method I, in which Eagle's MEM (minimum-essential medium) with 10% fetal calf serum was used as medium, the percentage of sheep red blood cell-rosette forming cells was 40.1±5.8% (mean ± s.d.) in 25 healthy individuals. By method II in which Hanks' BSS was used, it was 56.3±7.2% in 45 healthy individuals.
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  • Koji Ito, Yasuyuki Sano, Sumiki Miyachi, Yutaka Morita, Terumasa Miyam ...
    Article type: Article
    1975 Volume 24 Issue 9 Pages 681-687,690-69
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Mite antigen was labelled with ^<125>I and used in double antibody assay of IgG and IgA antibodies in ten patients who were allergic to both of house dust and mite. IgE antibodies were estimated by RAST. Results are as follows. 1)Level of IgE, IgA and IgG antibodies were higher in 10, 10 and 7 out of 10 patients respectively than in patients who were allergic to pollen but not allergic to mite. Markedly high level of both of IgG- and IgA antibodies was noted in two patients, one of which was treated with house dust and the another was not treated with any allergen. 2)IgM antibodies were not detected in patients as far as examined. 3)There was a patient whose immune response except IgE type response was very poor to immunotherapy with mite and house dust, whereas there was a patient whose immune response was very strong without immunotherapy. It was suggested from this observation that there was different distribution of antibodies in different class of immunoglobulins among patients who were similarly allergic to mite when stimulated with antigen. 4)Precipitin to mite seems to be related with IgG antibodies. When the ratio of level of IgG anti-mite antibodies to level of IgE anti-mite antibodies was compared between the group of patients treated with mite and the group of patients treated with house dust, high ratio was frequently observed in the former group.
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  • Article type: Bibliography
    1975 Volume 24 Issue 9 Pages 688-691
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Article type: Appendix
    1975 Volume 24 Issue 9 Pages 692-
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
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  • Article type: Cover
    1975 Volume 24 Issue 9 Pages Cover47-
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (35K)
  • Article type: Cover
    1975 Volume 24 Issue 9 Pages Cover48-
    Published: September 30, 1975
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (35K)
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