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Volume 25, Issue 1
Displaying 1-17 of 17 articles from this issue
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Article type: Cover
1976 Volume 25 Issue 1 Pages Cover1-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (49K) -
Article type: Cover
1976 Volume 25 Issue 1 Pages Cover2-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (49K) -
Article type: Bibliography
1976 Volume 25 Issue 1 Pages Misc1-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
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Barry R. BloomArticle type: Article
1976 Volume 25 Issue 1 Pages 1-9
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
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Yuusaku TakanoArticle type: Article
1976 Volume 25 Issue 1 Pages 10-16,48
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESS1.It was reconfirmed that 6 different leucocyte phenotypes designated AD, B, AC, ABC, ABD, ACD were identified in 106 outbred animals bred in Japan. The proportion of each phenotype was as follows: AD;42%, ACD;25%, AC;13%, ABD;12%, ABC;5%, B;3%. 2.The phenotype of JY-1 and Hartley-F was AD and that of JY-2 was AC. 3.From genetic study on leucocyte antigens in 38 animals from 6 families, both B and AD animals were proved to be homozygous. It is suspected that brother-sister mating of B or AD animals is more available to produce inbred strain. 4.Cross immunization with leucocytes in 2 pairs of AD animals did not yield new isoantiserum.View full abstractDownload PDF (975K) -
Sadako NoguchiArticle type: Article
1976 Volume 25 Issue 1 Pages 17-23,48-49
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEach sample of lymphocytes was collected from peripheral blood of 10 healthy subjects by Conray-Ficoll density gradient technique. The electrophoretic mobility (EPM) of 150-200 lymphocytes from individual subject was measured with a Sugiura's cylindrical cytopherometer using micro-injection method. Mathematical analysis of the EPM distribution curve (cytopherogram) of lymphocytes by Gaussian sum frequency paper showed that lymphocytes from normal persons devided into two subpopulations consisted of normal distribution. The first group (I_p), showing relatively faster EPM, had a mean EPM of -1.21±0.07 (μ/sec/V/cm) composed of 69% of the total cell population and the second group (II_p), showing the slower EPM, had a mean EPM of -1.07±0.05 (μ/sec/V/cm) composed of 31% of the total. Furthermore, the human lymphocytes were devided into 9 fractions by 35 to 17% bovine serum albumine density gradient technique in 2% BSA decrements. Each fraction was studied by mean-EPM and the sheep red blood rosette form-action as a T-cell marker simultaneously. Lymphocytes of fraction 4 and 5 were characterized by faster EPM population (I_p), and sheep red cell rosette formation in 80-98% of them. Lymphocytes of fraction 7, 8 and 9 were characterized by slower EPM population (II_p), 15% being T-cell. Considering our previous studies upon B-cell Leukemia and athymic mice in addition to the present results, it was concluded that normal human peripheral blood lymphocytes composed of two subpopulations electrophoretically; the faster EPM group (I_p) seems to corresponded to thymus dependent (T) lymphocyte and slower EPM group (II-) to thymus independent bone marrow derived (B) lymphocyte.View full abstractDownload PDF (1453K) -
Tatsuya Miki, Masaki Nishida, Masakazu Kikuoka, Ichita AmakiArticle type: Article
1976 Volume 25 Issue 1 Pages 24-31,49
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSphenomena were studied, and further, therapeutic effects of splenectomy. The immunosuppressants exibited suppressive effects on Coombs test and ANF in NZB and NZB (NZB×NZW) mice. Splenectomy at the age of one month suppressed relatively the development of Coombs positive hemolytic anemia and NTA on the one hand, it accelerated on the other hand the development of ANF. The immunosuppressants showed almost no effects on the splenectomized mice. These agents suppressed the progress of renal lesion of female NZB/W mice. Further, autoimmune phenomena were investigated which developed in normal mice grafted with autoimmune thymus.View full abstractDownload PDF (2236K) -
Ikuro Kimura, Yoshiro Tanizaki, Shuichi Sato, Katsuyoshi Saito, Kiyosh ...Article type: Article
1976 Volume 25 Issue 1 Pages 32-36,49
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe anti-inflammatory drug tiaramide, which was recently synthesized, has been reported to possess pharmacological features other than general inflammatory action. The additional actions of tiaramide are inhibition of PCA reaction in rats induced by reagin-like antibody and the inhibition of anaphylactic bronchospasm in rais and guinea pigs. Clinical effectiveness of tiaramide was examined in 50 patients with bronchial asthma with the following results: 1.In double blind evaluations of the clinical effect of tiaramide for one month, 17 out of 26 cases on tiaramide (65.4%) improved and the placebo effect was present in only 3 cases (11.5%). 2.Clinical effectiveness was not significantly different between the atopic type and infections type of patients. 3.Prolonged treatment with tiaramide resulted in approximately the same rate of effectiveness as the one month double blind study. 4.No case showed abnormality in clinical examinations before or after the tiaramide regimen.View full abstractDownload PDF (704K) -
Hiromichi UeharaArticle type: Article
1976 Volume 25 Issue 1 Pages 37-43,50
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAn investigation was performed to determine whether RA was associated with detectable alterations in percentages and absolute numbers of T and B lymphocytes in the blood or synovial fluid. Lymphocytes were isolated from heparinized blood or synovial fluid by Conray-Ficoll method. Membrane-bound Ig detectable with immunofluorescence technique was utilized as a marker of B lymphocytes, while the ability to blind sheep erythrocytes and form rosettes was interpreted as a T lymphocyte characteristic. In peripheral blood, both the percentage and absolute number of B lymphocytes were significantly higher in patients with RA than in normal subjects, while the percentage of T lymphocytes was not different from that in normal subjects, but absolute number of T lymphocytes was significantly lower than in normal subjects. In synovial fluid, the percentage of B lymphocytes was significantly lower than in peripheral blood, while the percentage of T lymphocytes was not different from that in peripheral blood.View full abstractDownload PDF (1089K) -
Yutaka Ishida, Hideo Onodera, Takahiro Tamura, Yoshio NanbaArticle type: Article
1976 Volume 25 Issue 1 Pages 44-47,50
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIgG mixed with IgM cryoglobulin (GM type) and sera obtained from 5 patients with active SLE showed positive precipitin reactions with Clq blobulin, whereas IgG cryoglobulin (G type) and sera from 5 patients with inactive SLE did not. Three out of 5 cases of GM type were of IgG-IgM-Clq mixed type and a case of IgG-Clq type through G type reacted with Clq. The Clq precipitin reactions of the sera did not occur when GM type were excluded by centrifugation from precipitation positive sera. The precipitin reactions of the Clq with heat inactivated cryoglobulin became stronger than those with untreated. The precipitin lines with Clq disappeared when the agarose gel plates were kept at 37℃, but a part of precipitin lines were reproduced when these plates were incubated at 4℃ again. The Clq precipitin reactions remained positive after DNase treatment of the GM type cryoglobulin and sera, but they disappeared after 2-ME treatment. As mentioned above, the precipitin reactions of the Clq with the sera and cryoglobulins occured simultaneasly and the positive reactions of Clq with the sera disappeared by the exclusion of cryoglobulin from sera. It is presumed that the Clq reactants in the sera of SLE patients are cryoglobulins with binding activity with complement component. GMClq type may correspond to the so called high molecular weight Clq reactant and GClq type to the low molecular reactant.View full abstractDownload PDF (615K) -
Article type: Bibliography
1976 Volume 25 Issue 1 Pages 48-50
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 1 Pages 51-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 1 Pages 52-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 1 Pages 53-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 1 Pages App1-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Cover
1976 Volume 25 Issue 1 Pages Cover3-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (55K) -
Article type: Cover
1976 Volume 25 Issue 1 Pages Cover4-
Published: January 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (55K)
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