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Volume 25, Issue 12
Displaying 1-17 of 17 articles from this issue
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Article type: Cover
1976 Volume 25 Issue 12 Pages Cover13-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Cover
1976 Volume 25 Issue 12 Pages Cover14-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (46K) -
Article type: Bibliography
1976 Volume 25 Issue 12 Pages Misc4-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Toru Hikita, Shigeru Nakatani, Yukio Matsumoto, Tetsuhiro Ninomiya, Yo ...Article type: Article
1976 Volume 25 Issue 12 Pages 803-814,847
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSChange of urinary catecholamine excretion after injection of 250 mg aminophylline was studied in 33 cases of bronchial asthma and in 5 healthy male subjects. Among the cases of bronchial asthma, 16 (age 13 to 61 years) were not treated with steroid hormone and 17 (age 13 to 61 years) were treated with steroid hormone. Blood sugar, plasma cortisol, plasma free fatty acids (FFA) and eosinophils in peripheral blood were also measured. Plasma cyclic AMP was estimated only in healthy subjects. In healthy subjects, the basal urinary adrenaline was 0.801±0.188 μg/h and it increased to 1.448±0.08 μg/h (P<0.01) after aminophylline injection. Oral administration of propranolol (20mg) did not inhibit the increase of urinary adrenaline, but inhibited the decrease of eosihophils and the elevation of plasma cyclic AMP due to aminophylline injection. In the cases of bronchial asthma untreated with steroid, the aminophylline injection increased urinary adrenaline from 0.71±0.43 μg/h to 1.1±0.66 μg/h (P<0.1). In the cases of bronchial asthma treated with steroid, the injection increased urinary adrenaline from 0.47±0.23 μg/h to 0.84±0.35 μg/h (P<0.1). FFA elevation by aminophylline in cases of bronchial asthma was not significantly different from in healthy subjects. In 9 of 15 cases of bronchial asthma eosinopenic effect of aminophylline was not shown like as healthy subjects. Blood sugar, plasma cortisol and urinary noradrenaline did not change significantly in healthy subjects due to aminophylline injection, nor in the cases of bronchial asthma. In conclusion, these results suggested that adrenaline release from adrenal medulla in cases of bronchial asthma might be blunted at least in response to aminophylline administration.View full abstractDownload PDF (1422K) -
Koji Ito, Yasuyuki Sano, Yutaka Morita, Terumasa Miyamoto, Yoshihiko H ...Article type: Article
1976 Volume 25 Issue 12 Pages 815-822,847-84
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSHouse dust is the main causative allergen of asthma in our country and hyposensitization treatment with house dust is widely used for immunotherapy of asthma. However, there are few reports about changes of serum antibodies during the treatment. It has been reported in pollinosis that total IgE and IgE antibodies increased at first and decreased thereafter, and IgG antibodies increased during hyposensitisation with pollen antigen. We examined whether or not these phenomena occur in patients sensitive to house dust and mite. Patients sensitive to both mite and house dust were separated to two groups. One group was treated with extract of house dust, and another group was treated with extract of mite. IgE, IgE antibodies and IgG antibodies were estimated during the treatments. As the major allergen in house dust is thought to be derived from mite, mite was used as antigen for estimation of antibodies in all treated individuals. In the group treated with mite, four of six individuals showed increase of IgE antibodies. IgE antibodies decreased in one patient and did not change in another patient. In the group treated with house dust, only one individual showed increase of IgE antibodies. Other individuals showed no change or showed only slight decrease. IgG antibodies increased in one of 5 individuals treated with mite, and in one of six individuals treated with house dust. IgE level changed variously in the cases. No paralellism was found between the changes of IgE level and titer of IgE antibodies. All treated patients showed improvement of symptoms. Therefore, the study of histamine release from leucocytes also should be done.View full abstractDownload PDF (1187K) -
Eisuke Kojima, Kazumi Kanda, Masahiro Kasai, Hirotaka Shinoda, Tsutomu ...Article type: Article
1976 Volume 25 Issue 12 Pages 823-828,848
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effects of KH-125 in combination with nonsteroidal antiinflammatory agents were evaluated on adjuvant arthritis as a model of rheumatoid arthritis. In the prophylactic experiment on adjuvant arthritis, the combined effect of KH-125 with aspirin, phenylbutazone and indomethacin was considered to be additive. The possibility to decrease toxicities of both KH-125 and nonsteroidal antiinflammatory agents by reducing dosages was also suggested.View full abstractDownload PDF (687K) -
Yasuhiko Tamada, Masaru Ohashi, Toshio Kobayashi, Takato Yoshida, Kyoj ...Article type: Article
1976 Volume 25 Issue 12 Pages 829-836,848-84
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSNC mice, bred from Japanese fancy mice by Kondo, show erythema and relative deficiency of hair on face, head and pinna. The symptom becomes usually around 5 months after birth and the most of affected mice died around one and half year. The detail observation on the skin lesion was done, the histopathological and hematological examinations were carried out in the NC mice. 1) In males the skin lesion began 3 to 4 months (average 3.6 months) after birth and the occurence of the disease was 90% in observed mice, on the other hand, in females the beginning of the skin lesion ranged in more broad age (average 4.5 months) and the occurrence of the disease was 60-70% in observed mice. 2) In serious skin lesions, erosion and ulcer occur. Histopathological examination of the skin lesions showed epidermal atrophy, hydropic degeneration of the basal cells and vasodilatation in the dermis. Simultaneously with skin eruption, depletion of lymphocytes were noted especially around post capillary venules in the lymph node and around central artery in the spleen, plasma cellular and reticulum cellular proliferation were observed and almost entive lymphocytes populations were gradually replaced by these cells. But the thymus did not so much change with aging. In aged mice, glomerulonephritis appeared. 3) Leukopenia was observed in the young mice (30-40 days). 60-70 percent of mice observed, showed anemia from 5-6 months of age. Based on the symptom observed in this experiment, it can be supposed that the NC mice have some immunological disorder.View full abstractDownload PDF (2778K) -
Teruaki SekineArticle type: Article
1976 Volume 25 Issue 12 Pages 837-842,849
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSImmune-adherence reaction (IA) has been described as a specific immunological reaction wherein microorganisms or other particulate antigen sensitized with antibody and complement become attached to the surface of primates erythrocytes, nonprimates platelets, macrophages or B-lymphocytes. The principle behind the IA reaction is the adherence of the C3b fragments generated by the activation of C3 with IA receptor on the surface of such cells. Until now IA was observed as an agglutination reaction of particulate antigen and target cells under a microscope or as an agglutination pattern at the bottom of a test tube, wherein quantitative and kinetic analysis of IA reaction was difficult. The following method of employing radio iodinated bovine serum albumin as an antigen has made such detailed investigations feasible. To avoid precipitation of antigen-antibody complex at low speed centrifugation prior to the participation of complement and human erythrocytes, low concentrations of antigen (less than 200 ng/ml) were used with their optimal concentration of antibody. When more than 50 ng/ml of antigen was used, the reaction reached a peak within 3 minutes at 37℃ while with 20 ng/ml, it required 60 minutes. In teraction of antigen-antibody-complement complex and human erythrocytes reached a peak within 15 minutes at 37℃ while at 0℃ it required longer than 60 minutes, indicating that this reaction was temperature dependent. Under these conditions, precipitation of antigen without complement was under 4%.View full abstractDownload PDF (851K) -
Yoshiro Katoh, Yoshifuji MatsumotoArticle type: Article
1976 Volume 25 Issue 12 Pages 843-846,849-85
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA new method to detect the Fc receptor of T-lymphocytes was applied to the normal peripheral human lymphocytes. The method was as follows: the lymphocytes were isolated by Ficoll-Conray gradient method. Washed lymphocytes were formed rosettes with sheep red blood cells (SRBC) in the plastic tube at 37℃ for 15 minutes and the cells were spun for 5 minutes at 1000 rpm. They were left at 0℃ for 60 minutes. The cells were gently resuspended and mixed with chicken red blood cells (CRBC), which were coated with heat aggregated human IgG_1 by means of treating the CRBC with tannic acid. Human IgG_1 was isolated from a myeloma protein. After incubating the cells suspension at 37℃ for 15 minutes and spun for 5 minutes at 500 rpm, they were then left at room temparature for 60 minutes. The cells were gently resuspended by shaking the pellet. Two hundreds lymphocytes were counted. The percentage of double rosette-forming cells with SRBC and CRBC was evaluated, a rossete being defined as a lymphocytes surrounded at least by three SRBC and two CRBC. Human lymphocytes did not form spontaneous rosettes with uncoated CRBC, moreover, double rossete-formation of T-lymphocytes with coated CRBC were blocked by adding free heat aggregated IgG_1. From these points double resette-forming lymphocytes with SRBC and CRBC would be T-lymphocytes bearing Fc receptors. Normal human blood contains 3.3±2.1% of double rosette-forming lymphocytes.View full abstractDownload PDF (673K) -
Article type: Bibliography
1976 Volume 25 Issue 12 Pages 847-850
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 12 Pages 851-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 12 Pages 852-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 12 Pages 853-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Index
1976 Volume 25 Issue 12 Pages 855-860
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 12 Pages 861-864
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Cover
1976 Volume 25 Issue 12 Pages Cover15-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (40K) -
Article type: Cover
1976 Volume 25 Issue 12 Pages Cover16-
Published: December 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (40K)
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