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Volume 25, Issue 5
Displaying 1-16 of 16 articles from this issue
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Article type: Cover
1976 Volume 25 Issue 5 Pages Cover29-
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Cover
1976 Volume 25 Issue 5 Pages Cover30-
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (44K) -
Article type: Bibliography
1976 Volume 25 Issue 5 Pages Misc7-
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
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Tadao Morito, Kiyoaki Tanimoto, Yoshimi Hashimoto, Yoshihiko Horiuchi, ...Article type: Article
1976 Volume 25 Issue 5 Pages 433-440,482
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSOne of B-cell specific alloantigens controlled by the gene locus in I-region of H-2 complexes was recently disclosed to be detectable by serological methods in mice. The antigens are called Ia-antigen (I-region associated antigen), and thought to be Ir-gene products. It was recently suggested that the antigen is identical or closely related to Fc-receptor on B-lymphocytes in mice. In human, even the presence of Ia-antigen is uncertain but it is possible that anti HLA sera may contain anti Ia like activities. In the present study, twelve anti HLA sera were used for the inhibition of Fc rosette formation and some of them imhibited the rosette formation without any relation of HLA type specificities of antisera and HLA haplotypes of used lymphocytes. The antisera retained most of inhibitory activities after the absorption with type-corresponding T-lymphocytes. Reduction and alkylation or sedimentation by ultracentrifugation of the anti HLA sera resulted in no marked reduction of the activities. These results indicated that the activity is independent from either immune complexes nature or anti HLA activity, and that it is B-cell specific and closely related to Fc receptor suggesting anti-Ia like activity in mice. It is well established that β_2 microglobulins compose a part of the HLA antigen molecule. Rabbit antiserum to human β_2-microglobulin markedly and uniformly inhibited the Fc-rosette formation, despite the different HLA type sources of lymphocytes. This suggested us that Fc-receptors have close relation with β_2-microglobulin and that a part of their molecules might be conposed of β_2-microglobulins like HLA antigens.View full abstractDownload PDF (1065K) -
Yukinobu Ichikawa, Kenji Koriyama, Yasunari Nakata, Shigeru Arimori, A ...Article type: Article
1976 Volume 25 Issue 5 Pages 441-446,482-48
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSeveral evaluating methods such as Schirmer test, measurements of salivary flow, parotid sialography, corneal stainings with fluorescein or rose bengal, and histological studies of salivary glands have been used for the diagnosis of Sjogren's syndrome. These methods were compared with histological appearances of sublingual salivary glands obrained from twenty-three patients. Moderate or massive lymphocyte infiltrations were always demonstrated in salivary glands of patients showing more severe figures than S Ib, namely punctate pattern sialographically. It was revealed, however, that these lymphocyte infiltrations might be found in salivary glands of patients with normal sialographic appearances. Schirmer test and salivary flow had few diagnostic values as well as complaints of xerostomia or xerophtalmia. Enlargements of salivary glands, keratoconjunctivitis sicca, arthritis and serological abnormalities were frequently found in patients with massive lymphocyte infiltration. Of our 23 patients undergone sublingual biopsies, 18 patients were diagnosed as Sjogren's syndrome according to the objective evidences of salivary or lacrimal gland involvements. Nine patients (50%) of them were Sjogren's syndrome alone, 8 patients had the manifestations of rheumatoid arthritis, systemic lupus erythematodes or myasthenia gravis, and one patient was associated with malignant lymphoma.View full abstractDownload PDF (1557K) -
Ryuzo Tomidokoro, Hiroshi Tamura, Makoto Takami, Shigeru Tomizawa, Hir ...Article type: Article
1976 Volume 25 Issue 5 Pages 447-451,483
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to make clinical investigations of focal infection, accurate diagnosis of infectious foci is very important. Hitherto humoral antibodies against streptococcal products, such as serum ASO (S-ASO), have been widely used as diagnostic indicators for streptococcosis, which is thought to be a main cause of focal infection. However, it is well known that a low level of such humoral antibodies does not necessarily exclude streptococcosis. Consequently, it has been important for us to establish new diagnostic methods which have different significance and can offset the faults of humoral antibody determinations. One of these is a new method established to measure the ASO activity in human blood leucocytes (C-ASO) by a modified Rantz-Randall method. Using this test, C-ASO titers were measured in 15 patients with scarlet fever throughout its clinical course. Results obtained were as follows: 1) C-ASO titers was found to be already very high in the first week of the illness, but significantly dropped in the second week when the acute symptoms disappeared. 2) C-ASO titers in all cases reached significantly high levels in comparison with the levels in healthy controls. 3) S-ASO titers were low during the first week, started to rapidly elevate and then reached a peak in the third or fourth week. 4) Temporary elevation of C-ASO in patients with scarlet fever during its acute stage suggests that similar elevations of C-ASO in those with other streptococcosis or focal infections during their clinical courses might have some etiologic significance.View full abstractDownload PDF (655K) -
Ikuro Kimura, Yoshiro Tanizaki, Katsuyoshi Saito, Kiyoshi Takahashi, N ...Article type: Article
1976 Volume 25 Issue 5 Pages 452-456,484
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA total of seventy three samples of sputum from nineteen patients with bronchial asthma were examined for the presence of basophils and eosinophils. The skin vesicle test was performed at the same time on nine cases. The results were obtained as follows: 1. Basophils were found in the sputum of the patients with bronchial asthma. The appearance of basophils was especially high in cases with severe refractory bronchial asthma with low serum IgE levels. The counts of basophils in sputum were higher at the end of attack. 2. The appearance of basophils of sputum was accompanied by many eosinophils in sputum. The presence of basophils in the sputum was related to the number of peripheral blood basophils. 3. The skin vesicle test exudate of severe refractory patients with bronchial asthma with sputum basophils, though in a few cases, seemed to reveal a higher frequency of basophils than eosinophils. 4. These results suggests that basophils move from the blood stream into the bronchial tissues during the acute phase of the asthmatic attack.View full abstractDownload PDF (714K) -
Hiroshi Tamura, Hideo Ishibashi, Makoto Takami, [in Japanese], Takayos ...Article type: Article
1976 Volume 25 Issue 5 Pages 457-465,484
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSFifty-two food allergens were determined by elimination and trial ingestion diets on 25 cases of chronic urticaria. They were soybean in 17, egg in 16 and cow's milk in 12 items (S:E:M=1.4:1.3:1.0), indicating the importance of soybean as offending allergens in chronic urticaria. Total IgE values as well as specific IgE values to β-lactglobulin, ovalbumin, rice and soybean were normal in 11 patients with chronic urticaria due to food allergy, except in 1 patient shown positive RAST score to rice and soybean.View full abstractDownload PDF (1259K) -
Suetsugu Mue, Tadao Ise, Shunsuke Suzuki, Shigeki Shibahara, Makoto Ta ...Article type: Article
1976 Volume 25 Issue 5 Pages 466-472,484-48
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe conductance of the total repiratory system (G) fo monkeys (Crab eating monkeys, Japanese monkeys, Pig-tailed monkeys and Taiwan monkeys) was measured by the forced 3Hz oscillation method using an endotracheal tube. There were no significant changes in G of monkeys after treating with propranolol. Inhalation of methacholine and histamine caused the slight decrease in G of monkeys irrespective of the propranolol treatment. Prior to the propranolol administration, the intravenous injection of methacholine (50-200μg per kg body weight) and histamine (30-50μg) caused bradycardia or convulsive reaction in the monkeys, but only slight changes in G. However, after propranolol, even a small dose of methacholine (50-60μg) given intravenously caused a marked decrease in G. There was no significant difference of the bronchial response to the intravenous injection of histamine due to the treatment with propranolol.View full abstractDownload PDF (1020K) -
Kenji EtooArticle type: Article
1976 Volume 25 Issue 5 Pages 473-481,485
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe present report was intended to examine a immunological mechanism of liver cell damage in chronic liver diseases which might be induced by humoral antibody and/or cellular immunity. With regard to humoral antibody, anti-liver cell membrane antibodies were examined by immuneadherence method, using isolated rat's liver cells, human red blood cells (O type. Ph+ve) and human complement (AB type. Ph+ve). Regarding cellular immunity, the pupolation of T and B lymphocyte in peripheral blood and macrophage migration inhibition test against a human liver homogenate (supernatant) obtained by necropsy were examined. The population of T lymphocyte decreased and that of B lymphocyte increased in chronic hepatitis (active form) as compared with normal subjects. Anti-liver cell membrane antibody was found in 80% of chronic hepatitis and macrophage migration inhibition was observed in 72% of chronic hepatitis (active form). Moreover, the peripheral blood lymphocytes formed rosettes with isolated rat's liver cells which were sensitized with anti-liver cell membrane antibody combined with or without human complement. The percentage of their rosette-forming liver cells was found to the extent of 8% in the former and 16% in the latter. It is possible to conclude from these results that the immunological cohesion of anti-liver cell membrane antibodies, complements and lymphocytes on the surface of liver cell is considered to be important for the further development of liver cell injury in chronic aggressive hepatitis.View full abstractDownload PDF (1514K) -
Article type: Bibliography
1976 Volume 25 Issue 5 Pages 483-485
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 5 Pages 486-
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 5 Pages 487-
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1976 Volume 25 Issue 5 Pages 488-489
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
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Article type: Cover
1976 Volume 25 Issue 5 Pages Cover31-
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (39K) -
Article type: Cover
1976 Volume 25 Issue 5 Pages Cover32-
Published: May 30, 1976
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (39K)
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