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Volume 26, Issue 10
Displaying 1-13 of 13 articles from this issue
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Article type: Cover
1977 Volume 26 Issue 10 Pages Cover5-
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Cover
1977 Volume 26 Issue 10 Pages Cover6-
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Bibliography
1977 Volume 26 Issue 10 Pages Misc2-
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
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IgE in Anaphylactoid Purpura and Acute Febrile Muco-Cutaneous Lymphnode Syndrome(Kawasaki's Disease)Susumu Furukawa, Minoru BabaArticle type: Article
1977 Volume 26 Issue 10 Pages 681-686,724
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSerum IgE levels in anaphylactoid purpura (AnP) and acute febrile muco-cutaneous lymphnode syndrome (MCLS) were measured by one step method of radioactive single radial immunodiffusion technique. In 20 patients of AnP at 2 to 9 years of age and 16 patients of MCLS at 1 to 9 years of age before steroid therapy, serum IgE levels were measured at respective acute stage. The results were as follows. 1) In AnP before steroid therapy, serum IgE level was inversely correlated to days from onset and duration after preceding infection. 2) In MCLS of non-steroid therapy, serum IgE levels decreased with the transition but on relapsed cases serum IgE levels increased. 3) The cases of high serum IgE level in AnP and MCLS were in the tendency of showing low level of thrombocytes. As Cochrance suggested in immune complex diseases, it might be considered that IgE is responsible for the beginning of AnP and MCLS. It is of interest in both diseases to consider the relationship between serum IgE levels and thrombocytes.View full abstractDownload PDF (610K) -
Yukinobu Ichikawa, Kenji Koriyama, Hideto Sakai, Shigeru ArimoriArticle type: Article
1977 Volume 26 Issue 10 Pages 687-693,724
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWistar rats were immunized with the microsomal or soluble fraction obtained from homologous submaxillary gland. Freund's complete adjuvant, and a mixture of B. pertussis vaccine and diphtheria toxoid were used as adjuvants. After immunization with the microsomal fraction, dense infiltration of mononuclear leukocytes with the formation of scattered focuses developed in their submaxillary glands. These mononuclear cell infiltrations emerged prior to the appearance of degenerative and/or obstractive changes of ducts as well as periductal fibrotic changes. These cell infiltrations diminished after the development of those degenerative changes. The mononuclear cells infiltrating in the glands were assumed to be T-cells (thymus derived cells) because of the absence of Fc and complement receptors on their cell surface. Humoral antibodies against the immunogens could not be detected in the sera of rats immunized with the microsomal or soluble fraction by any of the methods such as precipitation, agglutination and complement fixation. The presence of sensitized lymphocytes in their circulation was proved by the significant increase of 3^H-thymidine incorporation when they were stimulated with the microsomal fraction. Therefore, it is suggested that cellular immunity is the major mechanism in development of autoimmune sialadenitis.View full abstractDownload PDF (1502K) -
Yukinobu Ichikawa, Yozo Shimizu, Kenji Koriyama, Shigeru ArimoriArticle type: Article
1977 Volume 26 Issue 10 Pages 694-701,725
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSGuinea-pigs immunized with rat sarcolemma mixed with Freund's complete adjuvant developed myositic changes such as mononuclear cell infiltration, degeneration of muscle fibers, muscle atrophy including type I and type II muscle fibers, and swelling of motor end-plate. Transient elevation of serum GOT was observed in immunized animals, however, no significant difference was demonstrated between guinea-pigs immunized with rat sarcolemma and with adjuvant alone. The level of serum CPK in these animals was poorly reflected the process of immunization and the pathological changes. Electromyographic studies in immunized guinea-pigs, using direct supra-maximal tetanic stimulation on surgically exposed sciatic nerve, could not demonstrate so-called waning phenomenon of muscle action potentials. Complement fixing anti-rat sarcolemmal antibody was demonstrated in sera of guinea-pigs immunized with rat sarcolemma, but not in sera of guinea-pigs immunized with adjuvant alone. This complement fixing antibody was proved to be specific to rat sarcolemma because of the absence of the cross reactivities with sarcoplasmic reticulum, red cell ghost and liver extract obtained from rat. It was demonstrated that dissolved rat sarcolemma with alkaline water, sodium dodecyl sulfate, sodium deoxycholate or urea, had lost their reactivity with complement fixing antibody, probably due to the modifications of its antigenic structure. Transfer experiments of myositis and delayed type skin reaction to normal guinea-pigs, using the peritoneal exdative cells the lymphnode or spleen cells separated from immunized animals, was not successful yet.View full abstractDownload PDF (2075K) -
Sadaomi UchidaArticle type: Article
1977 Volume 26 Issue 10 Pages 702-708,725-72
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to determine whether or not childhood bronchial diseases are allergic in etiology, cytological analyses were carried out of the nasal smears taken from healthy children and of the nasal smears and sputa from the children suffering from allergic bronchitis, bronchial asthma and acute bronchitis. The following are the results and conclusions. 1) In healty children, no discernible differences were noted in nasal smears with different ages (0 to 12 years of age). 2) Not only eosinophils but goblet cells also were found to be important in the diagnosis of nasal allergy. 3) Analyses of nasal smears in bronchial diseases showed the allergic findings-increased eosinophils and goblet cells in the nasal smears-in 86.3% of the patients with asthma and in 74.8% of those with allergic bronchitis. 4) No differences were noted in the allergic findings of nasal smears between the asthmatic attack and the interim stage; in allergic bronchitis, the allergic findings were more frequently detected during the symptomatic stage than in the asymptomatic interim stage. 5) Eosinophilia in sputum was found in 88.8% of the patients with bronchial asthma and in 89.1% in allergic bronchitis. 6) Eosinophilia both in nasal smear and in sputum was observed in 66.0% of the cases of bronchial asthma and in 43.6% in allergic bronchitis, but no close relationship was demonstrated between the two measures. However, the results indicated that even if there was no eosinophilia in nasal smear it would not exclude the possibility of eosinophilia in sputum, and that eosinophilia in nasal smears is highly suggestive of eosinophilia in sputa. 7) In the examination of lower respiratory tract allergy, cytological study of the sputum is of great value in the diagnosis, but repeated examinations of nasal smears are also of value from the practical point of view as an auxiliary mesure for the diagnosis.View full abstractDownload PDF (1066K) -
Osamu Abe, Toshikazu Nemoto, Setsuo KobayashiArticle type: Article
1977 Volume 26 Issue 10 Pages 709-715,726
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThese experiments were carried out to investigate the intraassay variance, the recovery tests and the enough incubation in the time in IgE paper radioimmunosorbent test (PRIST). The correlation of the IgE values obtained with PRIST and RIST was also studied. In Japan, IgE values with IgE PRIST in healthy adults and asthmatic patients have not been reported. Therefore sera from 20 healthy adults and sera from 45 patients with asthma were analysed by IgE PRIST kits. And following results were obtained. 1) Intraassay Variance: The coefficients of variation (CV) at three different IgE levels(1234.4, 384.0 and 8.6 unit/ml) were 10.1, 3.0 and 17.4% (N=6). 2) Dilution tests by this method showed that IgE cocentration as low as about 0.5 unit/ml could be measured. The recovery rate in diluted (64 times) serum (expected level:0.6unit/ml) showed 68.8%. When 0.05ml of serum (484.8 unit/ml) was added to various cocentrations (50, 10, 2, 1 and 0.5 unit/0.95ml) of IgE standard solutions the recovery rates were 83.8, 101.2, 113.2, 102, 8 and 85.0%. 3) The enough first incubation time on the uptake of IgE by antibody coated paper discs was over 150 minutes, the enough second incubation time on the uptake of <125>^I-anti IgE was about 24 hours. 4) The IgE level by PRIST was 86% of that by RIST. 5) Healthy adults were found to have a mean value of 25.7 unit/ml and a standard deviation of 27.3 unit/ml in serum IgE level. 6) Asthmatic patients were found to have a mean value of 230.0 unit/ml and a standard deviation of 308.8 unit/ml in serum IgE level.View full abstractDownload PDF (812K) -
Yutaka Morita, Yasuko Matsumoto, Terumasa Miyamoto, Yoshihiko HoriuchiArticle type: Article
1977 Volume 26 Issue 10 Pages 716-723,727
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA sensitive and specific, single isotopic enzymatic assay for histamine is described. This method is based on the convertion of histamine to [<14>^C]-methylhistamine by incubation with S-adenosyl-L-methionine-[<14>^C] methyl and histamine-N-methyltransferase. This assay could detect as little as 3.9 ng of histamine. It was observed that compound 48/80 has the inhibitory effect to the isotopic enzymatic assay. Concanavalin A(Con A)-induced histamine release from cells of subjects with extrinsic asthema, intrinsic asthma or urticaria, and normal individuals was examined utilizing the single isotopic enzymatic assay for histamine. Maximum histamine release by Con A occurred with 0.9 to 4.5 μg/ml. The mean percentage of maximum histamine release by Con A from cells of donors with extrinsic asthma was 36 (±19.3)% while that from cells of normal individuals was 21.4 (±23.7)%. However, there was no significant difference between these two groups. The mean percentages of Con A-induced histamine release from leukocytes of individuals with intrinsic asthma, and urticaria were 14.4 (±8.7)%, and 8.9 (±8.7)%, respectively. The histamine release by Con A was not correlated with IgE level in the plasma (r=0.35).View full abstractDownload PDF (900K) -
Article type: Bibliography
1977 Volume 26 Issue 10 Pages 724-727
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 10 Pages 728-
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Cover
1977 Volume 26 Issue 10 Pages Cover7-
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K) -
Article type: Cover
1977 Volume 26 Issue 10 Pages Cover8-
Published: October 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K)
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