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Volume 26, Issue 4
Displaying 1-13 of 13 articles from this issue
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Article type: Cover
1977 Volume 26 Issue 4 Pages Cover25-
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (41K) -
Article type: Cover
1977 Volume 26 Issue 4 Pages Cover26-
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (41K) -
Article type: Bibliography
1977 Volume 26 Issue 4 Pages Misc6-
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (234K) -
Takao NishimuraArticle type: Article
1977 Volume 26 Issue 4 Pages 369-377,414
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe antibodies to native DNA (N-DNA) were detected in the sera of patients with systemic rheumatic diseases by the ammonium sulfate method using N-DNA combined with actinomycin D (^3H) in vitro. The serum level of the antibodies was represented by the per centage of DNA binding activity. The high DNA binding activities were limited to the sera of patients with clinically active systemic lupus erythematosus (SLE). The clinical improvement was accompanied by their reductions to the normal range. The shaggy unclear immunofluorescent patterns were produced by the sera with high DNA binding activities. The most patiens with high DNA bindings had low levels of serum complement and tended to have the active renal disease, simultaneously. When the DNA binding activities were compared before and after the treatment of the sera with DNase, there were significant increases in the activities in 5 out of 30 sera of patients with SLE after the digestion with DNase. When those sera were fractionated by the methylated albumin kieselguhr chromatography, two small peaks were observed at the elution buffer of 0.6 molarity of sodium chloride. One of those was a peak of N-DNA and the other one was presumably the peak of soluble DNA-anti DNA complexes. These findings strongly suggest that the detection of the antibodies to native DNA by ammonium sulfate method provide a diagnostic and therapeutic aid to the management of the patients with systemic lupus erythematosus. In addition DNA-anti DNA complexes might be formed in some sera of patients with SLE and prepare the way for the development of renal disease.View full abstractDownload PDF (1109K) -
Kentaro Higuchi, Shunji Nakagawa, Mitsue KatsudaArticle type: Article
1977 Volume 26 Issue 4 Pages 378-384,414-41
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn our previous report were stated the results of the survey on atmospheric pollens in West-Japan carried out in co-operation with our associates during 3 years in Kyushu area and one year in Cugoku and Shikoku areas. In this report the authors descibed some interesting cases with the pollinosis of Dalmatian chrysanthemum in the Inland Sea are, pollinosis of Boemeria nipponivea (Urticaceae) in Nagasaki and pollinosis of Fragaria chiloensis (strawberry) in Fukuoka, that were found in the West Japan through the above-mentioned investigation. In addition to this, the authors could advocate the need of investgation to the antigenicity of the following pollnens: Casuarina equisetifolia in Okinawa; Cosmosbipinnatus, Ginkgo biloba, Fugus Crenata (beach) and Juglandaceae (walnut) in other areas. As to the frequency order of positive reaction to the intracutaneous test with pollen extracts carried out to the allergic patients who were examined at the Examination Center of the Kyushu University Hospital, allergic rhinitis was the highest, which was followed by asthma-loke disorders.View full abstractDownload PDF (1542K) -
Kazuhide Banno, Tetsuro YoshimuraArticle type: Article
1977 Volume 26 Issue 4 Pages 385-391,415
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis experiment was an attempt to investigate the influence of N-(3′, 4′-dimethoxycinnamoyl) anthranilic acid (N-5′) on the synthesis, release and degradation of histamine, and following results were obtained. 1) N-5′only at a concentration of 1000μM showed about 58% inhibition on histamine formation mediated by crude gastric histidine decarboxylase of rats. However, the enzyme activity was unaffected by an I.p. injection of N-5′at a dose of 200mg/kg or less. 2) N-5′at concentrations of 100 and 1000μM showed a significant inhibition (about 51 and 95%, respectively) of the histamine release from peritoneal cells mediated by HTA, while the drug did not affect the spontaneous histamine release and that by compound 48/80 at a concentration sufficient to elicit an inhibition of the allergic histamine release. 3) N-5′only at a concentration of 1000μM showed about 44% inhibition on histamine degradation mediated by crude histaminase from rat duodenum. 4) Histamine levels in whole blood, peritoneal cells, lung, trachea and spleen of rat were hardly changed by an oral administration of N-5′at a dose of 600mg/kg or less.View full abstractDownload PDF (906K) -
Yasuo Horiuchi, Tsuneo Tsuruhara, Takeyuki SugaharaArticle type: Article
1977 Volume 26 Issue 4 Pages 392-398,415-41
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSExperiments were carried out on 11 asthmatic children aged between 11 and 15 years. Each subject inhaled an aerosol of PGE (as triethanolamine salt) generated from a 10μg/ml solution, from a pressure cycled ventilator (Bennet) adjusted to nebulized on inspiration only. The dosage of used PGE was 10-20μg. Measurements of FEV_1 and respiratory resistance were taken before and 15 minutes after inhalation. Blood histamine levels and plasma cAMP levels were measured before and 30 minutes after inhalation. There were no change in the FEV_1 but a decrease in respiratory resistance following the inharation, though eldery subjects noticed slight irritation of upper respiratory tract. The inhalation of PGE_1 resulted in a significantly fall in mean blood levels of histamine. This was associated with an increase of plasma cAMP levels. Mean blood histamine level before and after inhalation was 0.045±0.013 and 0.039±0.009 (μg/ml). Mean plasma cAMP level of the same sample was 4.3±3.6 and 16.7±22.6 (p mol/ml).View full abstractDownload PDF (946K) -
Shuji SuzukiArticle type: Article
1977 Volume 26 Issue 4 Pages 399-404,416
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn vitro passive sensitization of guinea pig tracheal rings with homocytotropic antibodies was demonstrated. The passive tracheal anaphylaxis (PTA) reactions were expressed by values on four parameters. Each parameter was thermo-dependent. At 37℃, under low oxygen supply, the following were observed: Latent periods, which were lacking in curves induced by histamine paralleled reversedly with antigen doses at a given antiserum dilution. The contracting phases were within a narrow range (1′44″±0.22″) irrespective of concetrations of antiserum and antigen. Antigen doses had a trend to parallel with heights of contraction peak at a given antiserum dose and vice versa. Γ_1 antibody masked the activity of reaginic antibody. Contractions induced by antigen fell to the baseline aroud 15 minutes after the challenge while curves induced by histamine had T1/2 values (the period elapsing between the time of challenge and the point at which relaxation phase falls to half of the contraction peak) far over 15 minutes. Increased oxygen supply elongated T1/2 values remarlably through abolishing the later portion of the relaxation. The meaning of each parameter and the applicability of PTA reactions were shortly discussed.View full abstractDownload PDF (912K) -
Toshitada TakemoriArticle type: Article
1977 Volume 26 Issue 4 Pages 405-413,416
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDifferential suppressive effect of carrier specific suppressor T cell was examined in primary and adoptive secondary antibody responses. The suppressor T cell, when it was given in the early stage of primary immunization (day 0 to 2), induced a strong suppression of IgG antibody response with little effect on IgM antibody response. If the same cell was given later (on day 3), the effect was mainly directed to the pre-existing IgM antibody response resulting in the early termination of antibody response, while IgG antibody response was only slightly suppressed. The suppression of adoptive secondary antibody response was considerably less than that observed in primary antibody response. It was further found that under the influences of the suppressor T cell the maturation of antibody avidity was greatly suppressed. This was shown by the fact that the number of antibody-forming cells producing high avidity antibody was selectively reduced in the presence of suppressor T cell leaving the number of low avidity antibody-producing cells unaffected. Suppressor T cell induced by immunization with the mixture of antigen and Freund's complete adjuvant could suppress the adoptive secondary IgE antibody response as well as IgG antibody response, but those induced without Freund's adjuvant could not suppress IgE antibody response. These results indicate that the suppressor T cell exerts differential suppressive effects depending on 1) the stage of differentiation of B cells after antigenic stimulation 2) the immunoglobulin class of produced antibody 3) avidity of antibody to be produced by B cells.View full abstractDownload PDF (1330K) -
Article type: Bibliography
1977 Volume 26 Issue 4 Pages 414-416
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 4 Pages 417-419
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Cover
1977 Volume 26 Issue 4 Pages Cover27-
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (47K) -
Article type: Cover
1977 Volume 26 Issue 4 Pages Cover28-
Published: April 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (47K)
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