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Volume 26, Issue 7
Displaying 1-17 of 17 articles from this issue
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Article type: Cover
1977 Volume 26 Issue 7 Pages Cover37-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (43K) -
Article type: Cover
1977 Volume 26 Issue 7 Pages Cover38-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (43K) -
Article type: Bibliography
1977 Volume 26 Issue 7 Pages Misc9-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
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Tomio AkiyamaArticle type: Article
1977 Volume 26 Issue 7 Pages 521-526,563
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSNinety-eight patients with atopic dermatitis were examined for specific IgE antibodies by RAST. A higher number of positive RAST reactions was found in patients with higher serum IgE value and with coexisting asthma and/or allergic rhinitis. The positive RAST reactions against mite and house dust was found in many of those patients and in about one half of even patients with atopic dermatitis only. The comparisons between intradermal tests and RAST were made with various allergens and the mite extract showed the best agreement between these two tests.View full abstractDownload PDF (739K) -
Shinichi Aotsuka, Masako Okawa, Kenji Ikebe, Ryuichi Yokohari, Yasuoki ...Article type: Article
1977 Volume 26 Issue 7 Pages 527-533,563
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe sensitivity and the specificity of the Millipore filter assay for the detection of antibodies to double stranded (ds) DNA depends very much on the reaction conditions. The interaction between ds DNA and anti-ds DNA is inhibited when ionic strength and pH are increased. Double stranded DNA is bound by inactivated normal sera at ionic strength lower than 0.11 M Tris-HCl buffer (pH 7.6) and at physiological ionic strength when the pH is lower than 7.2. The binding of ds DNA by fresh normal sera takes place in 0.15 M Tris-HCl buffer (pH 7.6). Such binding mainly due to Clq is reduced by heating sera for 120 minutes at 56℃.View full abstractDownload PDF (881K) -
Susumu Miyake, Seizo Yamana, Koji Nishiya, Tadashi OfujiArticle type: Article
1977 Volume 26 Issue 7 Pages 534-541,563-56
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSMacrophage localization in the site of immune response has been investigated using FITC-labelled anti-macrophage antibody. The specificity of anti-macrophage sera which have been applied so far, has not always been critically evaluated, resulting from the cross reactivity with other cell components. In the present work, rabbit anti-guinea pig serum (AMS) which specifically reacts with guinea pig peritoneal macrophage has been successfully prepared by the absorption with various organs, such as red blood cells, spleen non-adherent cells and kidney homogenate. Specificity was examined by immunofluorescent technique and immunodiffusion. In addition, macrophage specific antigen was further investigated by the sucrose gradient technique, by which macrophages were fractionated into crude nuclear fraction (M1), crude mitochondrial fraction (M3), crude microsomal fraction (M5) and their supernatant (M4). Each of these fractions was tested by immunodiffusion against AMS before and after absorption. AMS before absorption revealed numerous precipitine lines against M1, M3, M5 and M4. In contrast, absorbed AMS demonstrated only one precipitine line against M3 and M5. Precipitine line seen in M3 and M5 was fused. These data, therefore strongly suggested that the absorbed AMS gained high specificity against macrophage specific antigen which localized in the crude mitochondrial and microsomal fractions.View full abstractDownload PDF (1542K) -
Masato Nakayama, Seizo Yamana, Hideki Matsueda, Kaname Ono, Tadashi Of ...Article type: Article
1977 Volume 26 Issue 7 Pages 542-547,564
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPHA-dependent cell mediated cytotoxicity (PDCC) and antibody dependent cell mediated cytotoxicity (ADCC) were applied to assess the effector activity of the lymphocytes in the patient with lung cancer. For ADCC, ^<51>Chromium-labelled Chang cells, and peripheral mononulear cells, separated by Conray-Ficoll sedimentation method were mixed. To it, rabbit anti-Chang cell antibody diluted 10^<-5> was added and radioactivity in the supernatant obtained after incubation was counted. Activity of ADCC was expressed as % release. For PDCC, peripheral mononuclear cells were incubated with PHA-P 30μg/ml for 24 hours and then, ^<51>Cr-labelled cells were added for further 24 hour incubation. Radioactivities of the supernatant were counted to be expressed as % release as an activity of PDCC. PDCC activity was low in the cancer group. ADCC tests revealed no significant difference in the mean value of the cancer group compared with that of normal persons. The cancer group, however, revealed large variations in ADCC and could be classified into three groups, i.e., high, medium and low response groups. The present data, therefor suggested that lymphocyte functions in the patient with lung cancer could be reduced and altered as measured by ADCC and PDCC.View full abstractDownload PDF (771K) -
Motohiro Kurosawa, Toshikazu Nemoto, Hideo Aoki, Masashi Inazawa, Aiko ...Article type: Article
1977 Volume 26 Issue 7 Pages 548-553,564-56
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRecently, the action of prostaglandins on allergic reactions are noted by many investigators. Experiments were performed to study the action of prostaglandins on histamine release from sensitized rat's peritoneal mast cells by the antigen. The following results were obtained. 1) PGE_1, in doses of 0.1, 1, 10μg/ml, inhibited histamine release from sensitized rat's mast cells by the antigen. 2) PGE_2 or PGF_<2α>, 0.1μg/ml, did not affect histamine release and in a dose of 1μg/ml, inhibited that slightly, but not significantly. Whereas, they inhibited histamine release significantly in a dose of 10μg/ml. 3) Mixture of PGE_2 and PGF_<2α> in a dose of 0.1μg/ml, enhanced histamine release and at a mixture ratio of 5:5 PGE_2 and PGF_<2α>, the potentiation of histamine release seemed to be the greatest.View full abstractDownload PDF (857K) -
Tohru TakayamaArticle type: Article
1977 Volume 26 Issue 7 Pages 554-562,565
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSChildren who wheeze slightly but distinctly at night or dawn without subjective and objective signs of dyspnea were diagnosed as having incipient asthma. Allergic studies were carried out on 131 such cases, and the following have been the conclusions. 1) The peak age of occurrence was 6 years, which agrees well with that of the typical bronchial asthma. 2) The sex ratio also agrees with that of the typical bronchial asthma. 3) There was no difference in the frequency of positive history for allergy in the patients and their families when compared with that in allergic bronchitis, but it was lower than that in the typycal bronchial asthma (p<0.01). 4) High-pitched ronchi were less frequently heard as compared with the typical bronchial asthma, but it was more frequent that in allergic bronchitis (p<0.01). 5) The frequency of positive response to adrenaline was not different from that in the typical bronchial asthma, but was higher than that in allergic bronchitis (p<0.05). The frequency of a drop in FEV_1 was all the same results. 6) No difference was noted between the three groups in the frequency of positive increase in eosinophils in peripheral blood. The absolute increase in eosinophils was not different from that in allergic bronchitis but was smaller when compared with the typical bronchial asthma (p<0.01). 7) The serum level of IgE was greater than 700 unit/ml in 15 out of 25 (60%), and the comparable figure for allergic bronchitis was 50%; the difference was not significant. 8) The frequency of positive skin test against house dust was not different from that in the typical bronchial asthma but was higher than that in allergic bronchitis (p<0.01). With 5 other inhalant antigens, no difference was obtained. 9) There was no difference among the three groups in the frequency of increase in eosinophils in nasal smear and washed sputum. 10) An acoustic analysis of wheezing demonstrated low-pitched wheezing with big amplitudes below 2000c/s and high-pitched wheezing with 2000-8000c/s in stadium acmes of the typical bronchial asthma. In contrast, low-pitched wheezing with small amplitudes below 2000c/s was the predominant featuer in bronchitis.View full abstractDownload PDF (1332K) -
Article type: Bibliography
1977 Volume 26 Issue 7 Pages 563-565
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1977 Volume 26 Issue 7 Pages 566-567
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 7 Pages 568-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 7 Pages 569-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1977 Volume 26 Issue 7 Pages 569-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (58K) -
Article type: Appendix
1977 Volume 26 Issue 7 Pages 570-572
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
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Article type: Cover
1977 Volume 26 Issue 7 Pages Cover39-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Cover
1977 Volume 26 Issue 7 Pages Cover40-
Published: July 30, 1977
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K)
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