Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 27, Issue 5
Displaying 1-13 of 13 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 5 Pages Cover21-
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover21
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 5 Pages Cover22-
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover22
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1978 Volume 27 Issue 5 Pages Misc7-
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Misc7
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  • The changes in the Complement System in Immunoglobulin in Disorders
    Kuniko Mori, Kiyoshi Takatsuki
    Article type: Article
    1978 Volume 27 Issue 5 Pages 481-493,539
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.481
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    The changes in the complement system were studied in 146 cases with immunoglobulin disorders, including 80 with multiple myeloma(30 with IgG, 22 with IgA, 6 with IgD, 20 with Bence Jones protein and 2 with nonsecretory myeloma), 14 with primary macroglobulinemia, 5 with other monoclonal gammopathy, 20 with hypogammaglobulinemia and 27 with polyclonal hypergammaglobulinemia. CH_<50> was determined by modified Mayer's method, β_<1C>/β_<1A> and β_<1E> globulins were by single radial immunodiffusion. C1, C2, C4 and C3-9 hemolytic activities were determined by the use of their respective intermediate cells in the selected cases. The results were as follows. 1) The level of β_<1E> globulin was low in IgG myeloma, primary macroglobulinemia, polyclonal hypergammaglobulinemia and high in IgA, IgD and BJP myelomas and secondary hypogammaglobulinemia. A reciprocal correlation was observed between β_<1E> globulin and IgG or IgM levels. 2) The values of β_<1E> globulin determined by radial immunodiffusion showed a good parallelism to the C4 hemolytic activity. 3) There was no correlation between the C4 activity and CH_<50>. 4) The increase of β_<1E> globulin in the disease states was more remarkable than that of β_<1C>/β_<1A> globulin. It is postulated that complement, particularly C4, may be consumed by IgG and IgM, whether normal or monoclonal, in their catabolic processes. Therefore, high C4 levels in some cases may attribute to the decreased consumption of C4 due to low levels of IgG and IgM.
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  • Observation of Keyhole Limpet Hemocyanin(KLH)-Binding T Cells by Scanning Electron Microscopy
    Tateo Matsuzawa
    Article type: Article
    1978 Volume 27 Issue 5 Pages 494-503,540
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.494
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    Lethally irradiated mice were reconstituted with normal thymocytes followed by an intraperitoneal immunization with keyhole limpet hemocyanin(KLH). Spleen cells of these mice were harvested 7 days after the immunization and regarded as the'educated'T lymphocytes. The cells were incubated with the associated form of KLH(M.W.approximately 7,000,000) at 37℃ for 30 min. KLH-binding cells were examined by a scanning electron microscopy. About one to two per cent of the educated T cells bound KLH molecules which were observed as syrindrical particles attached to the smooth hemisphere of cell membrane but not on microvilli. Uneducated T cells treated with KLH in a similar manner contained almost negligible number of antigen-binding cells. The treatment of antigen-binding cells with anti-Thy-1 alloantiserum and complement produced numerous holes on the cell membrane, indicating that the cells binding KLH in this system were Thy-1 antigen positive(T cells). The antigen-binding T cells were slightly larger in size(ca. 5μ in diameter)than antigen-binding B cells(approximately 4 μ in diameter). The number of KLH molecules bound to T cells was generally much smaller than that on B cells. This binding of KLH molecules to T cells was temparature dependent, and only a small number of KLH molecules was found to bind to T cell membrane at 0℃. No cap formation was observed in the antigen-binding T cells even after incubation at 37℃ for 30 min.
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  • Studies on Effects of Drugs on Guinea-Pig Tracheal Smooth Muscle : II. Actions of Prostaglandins under Various Experimental Conditions
    Hideo Aoki
    Article type: Article
    1978 Volume 27 Issue 5 Pages 504-511,540
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.504
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    Recently, several reports have been devoted to the relationships existing between prostaglandins and bronchial asthma, but physiological roles of prostaglandins on respiratory smooth muscle have not been established. Experiments were performed to study the actions of prostaglandins(PGs)on tracheal smooth muscle in various experimental conditions using tracheal spiral from guinea-pigs. The following results were obtained. 1) Under weakly stretched conditions of the spiral or at the low concentrations of the drug, PGE_2 contracted the spiral with a dose-independent fashion, but relaxed it under strongly stretched condition of the spiral and at the higher concentrations of the drug with a dose-dependent fashion. 2) In contrast, PGE_1 always relaxed and PGF_<2α> always contracted the trachea in a concentration-related manner at the same concentrations and the stretching as did PGE_2.
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  • Immune Response to Lipopolysaccharide : Demonstration and Properties of Suppressor T cell
    Yuichi Gyotoku
    Article type: Article
    1978 Volume 27 Issue 5 Pages 512-520,541
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.512
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    There has been conflicting data concerning the involvement of suppressor T cells in T cell independent antibody response. For this reason, the antibody response of mice immunized with LPE(E.coli)was investigated by assaying the anti-LPS PFGs of spleen. 1) When mice were pretreated with 1 ng LPS before immunization of 1μg LPS, their PFC response to LPS was suppressed. This suppression was the most evident in mice pretreated 3 days before immunization. 2) Since this suppressive effect of pretreatment was abrogated by ALS injection into pretreated mice, it was suggested that the suppression was brought about by sppressor T cells. But, without LPS pretreatment, the participation of suppressor T cells in antibody formation to LPS could not be proved even with the ALS administration. 3) This suppressive phenomenon was observed in two strains of mice: ICR and C3H/He. Ths strict antigen specificity existed in this suppression. 4) The mice immunized after the transfer of educated spleen cells showed suppressed PFC production to LPS. The suppressive ability of educated spleen cells disappeared when these cells were treated with anti-T cell scrum and complement. Therefore, it was conformed that the suppression occured by LPS pretreatment was due to suppressor T cells.
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  • Serum Immunosuppressive Factor(s) in Children with Nephrotic Syndrome : I. Effects of the Serum on Mitogen-Induced Lymphocyte Transformation
    Hiroshi Matsuoka, Atsuo Urisu, Shinpei Torii, Michiko Matsuoka, Shigem ...
    Article type: Article
    1978 Volume 27 Issue 5 Pages 521-530,541-54
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.521
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    We have studied immunological abnormalities of the patients with nephrotic syndrome(NS), in respect with mitogen-induced blastogenesis of their lymphocytes and the effect of the sera on lymphocyte response. Lymphocytes and sera collected from 23 patients with NS aging from 3 to 16 years old, were assayed. And then we have obtained following results. 1) The decreased responsiveness of lymphocytes of NS patients to PHA-M stimulation was shown. 2) Sera from 20 patients before any treatment significantly inhibited PHA-induced transformation of the lymphocytcs from both healthy donors and patients own. 3) The suppression of transformation exhibited by serum in active phase before theraphy disappeared in convalescent phase of the disease. 4) Concanavalin A, pokeweed mitogen-induced lymphocyte transformation were also significantly inhibited by the pretreatment sera during active phase of NS. 5) Even when these sera were supplemented with human albumin or pooled normal serum, this suppressive effect was also observed. It suggested that the inhibitory effect was assumed to be not due to the lack of optimal nutrient capacity, but due to the presence of inhibitor(s) in NS serum. 6) The inhibitory activity was observed in the serum from the patients with any histological finding such as minimal change, proliferative, membranous and sclerosing glomerulonephritis. 7) Significant correlation between the serum inhibitory activity and serum α_2-macroglobulin level was observed.
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  • The Effects of Lipopolysaccharide and other Mitogens on the Immunoglobulin Synthesis by Human Peripheral Blood Lymphocytes Induced by Pokeweed Mitogen
    Toshiro Nakagawa, Junichi Yata
    Article type: Article
    1978 Volume 27 Issue 5 Pages 531-538,542
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.531
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    The effects of bacterial lipopolysaccharide(LPS)and other mitogens on the immunoglobulin-producing response induced by pokeweed mitogen(PWM)were studied. Addition of LPS at the same time as PWM enhanced the appearance of cells possessing cytoplasmic immunoglobulin(C-Ig). This adjuvant effect of LPS could not replace for T cell, and T cell help did not require DNA synthesis for expression. Whereas, LPS treatment of lymphocytes one or two days before the PWM-stimulation rather suppressed the production of C-Ig cells. This suppression was cancelled by addition of untreated T cells. These results indicate that the adjuvant effect of LPS is time-dependent. Both phytohemagglutinin and concanavalin A added at the same time, at various doses, suppressed the generation of C-Ig cells.
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  • [title in Japanese]
    Article type: Bibliography
    1978 Volume 27 Issue 5 Pages 539-542
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.539
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 5 Pages 543-544
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.543
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  • [title in Japanese]
    Article type: Appendix
    1978 Volume 27 Issue 5 Pages 545-549
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.545
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  • [title in Japanese]
    Article type: Cover
    1978 Volume 27 Issue 5 Pages Cover23-
    Published: May 30, 1978
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.27.Cover23
    JOURNAL FREE ACCESS
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