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Volume 28, Issue 1
Displaying 1-12 of 12 articles from this issue
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Article type: Cover
1979 Volume 28 Issue 1 Pages Cover1-
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (31K) -
Article type: Cover
1979 Volume 28 Issue 1 Pages Cover2-
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (31K) -
Article type: Bibliography
1979 Volume 28 Issue 1 Pages Misc1-
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (258K) -
Shigeko Inokuma, Terumasa MiyamotoArticle type: Article
1979 Volume 28 Issue 1 Pages 1-6
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSCase 1: 40 yr-old male. After working for 7 years covering type with gum arabic solution, the patient contracted rhinitis. One year later, the rhinitis subsided but asthma began. No attacks occured on his off days. Prick skin test, inhalation provocation test, RAST and precipitin test by gum arabic were positive. A high IgE level and eosinophilia were noted. A change to another job in the factory and the usage of bronchodilators or disodium cromoglycate relieved his symptoms. Case 2: 48 yr-old female. After working for 6 years in an office retailing gum arabic, rhinitis began. Prick skin test and nasal provacation test by gum arabic were positive. IgE level was within normal limits and mild eosinophilia was noted. The attacks were controlled well by an anti-histamine. Among 11 workers in this retailing office, 9 including case 2 were examined by prick test and questionnaire. Four of the 9 were positive by prick test. Three out of 4 had rhinitis and another had urticaria. This high indicence of positive skin test was statistically signifficant as compared with normal or atopic patients. Gum arabic is suggested to be one of the important inhalative antigens in occupational atopic allergy.View full abstractDownload PDF (985K) -
Shunichi KumagaiArticle type: Article
1979 Volume 28 Issue 1 Pages 7-14
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSImmune complexes in sera of patients with SLE were detected by ADCC inhibition. Chang cells and normal peripheral lymphocytes were used as the target and effector cells, respectively. ADCC was almost linearly inhibited by human aggregated IgG added to the medium. When ovalbumin and rabbit anti-ovalbumin antibody were added in equivalent doses to the test medium, ADCC was also inhibited at concentrations between 0.03 μg/ml and 30 μg/ml. Ten fold diluted sera of patients with active SLE inhibited ADCC by 47.2±8.0% (mean±SE), whereas normals were inhibited by it to a far lesser degree. The degree of inhibition did not correlate with the titer of anti-DNA antibody. Sera which obtained a higher anti-DNA antibody titer after DNase digestion were considered to contain DNA-anti-DNA complexes (DNA complex) and exhibited a significantly strong inhibition of ADCC. Inhibition of ADCC significantly increased when DNA complexes were produced in vitro by adding native-DNA to the SLE serum. ADCC was surely inhibited by DNA complexes though it was also affected by other factors including rheumatoid factor, aggregated IgG and steroid hormones.View full abstractDownload PDF (945K) -
Hiroshi InabaArticle type: Article
1979 Volume 28 Issue 1 Pages 15-21
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe respiratory function of 10 asthmatic children showing bronchoconstriction by master two step test (24×/min, 6 min) and 8 normal school children was compared while pool swimming. The respiratory function of 27 asthmatic children and 5 normal healthy adlescents was also compared while sea swimming. In short distance (100m) pool swimming, there were only small changes in %PFR, %FVC, %FEV_<1.0>, -2.9%, -3.8%, , -7.0%, mean decrease respectively after 5 min of swimming. None of the asthmatic children were provoked into an asthmatic attack. In long distance pool swimming, the asthmatic children's respiratory function showed small changes in %PFR, %FEV_<1.0>, -4.8%, -9.5% mean decrease respectively after swimming. Two patients had slight wheezing, but this diminished after 5 min. Sea swimming, consisted of 15 min of swimming and 10 min of rest repeated 4 times. The %PFR of asthmatic children showed a 6.5% increase immediately after swimming and was still 5.1% elevated 2 hours later. Five patients out of 27, suffered slight asthmatic attacks, including 2 patients with severe bronchial asthma who showed prolonged wheezing lasting longer than 2 hours. In conclusion, swimming is an eminently suitable method of physical training for asthmatic children. But we must consider the patients' age, physical capacity and the severity of disease at the beginning of long term, regular swimming training.View full abstractDownload PDF (927K) -
Sunao TsukamotoArticle type: Article
1979 Volume 28 Issue 1 Pages 22-30
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRosette formation has been reported to be characteristic of both unsensitized sheep red blood cells (SRBC) with human thymus dependent lymphocytes (T cells) and unsensitized rabbit red blood cells (RRBC) with guinea pig thymus dependent lymphocytes (T cells). However, the precise mechanism of these phenomena has not yet been clearly analyzed. The present study was undertaken to isolate and characterize the SRBC ligand for human T lymphocytes and the RRBC ligand for guinea pig T lymphocytes. SRBC and RRBC membranes were extracted with 0.1 mM ethylendiaminetetraacetate (EDTA), pH 8.0, and were further solubilized by the addition of Triton X-100. The soluble membrane extract was separated by affinity chromatography on a Con A-Sepharose 4B column. Eluates were designated SRBC-ME (Con A) and RRBC-ME (Con A), respectively. On polyacrylamide gel electrophoresis (pH 8.9), SRBC-ME (Con A) showed a single Amido black staining, PAS positive band. RRBC-ME (Con A) exhibited two bands, also stained with Amido black and PAS. The biological activities of SRBC-ME (Con A) and RRBC-ME (Con A) were assessed by SRBC rosette and RRBC rosette inhibition assay. SRBC-ME (Con A) inhibited SRBC rosette formation, 50% inhibition requiring approximately 100 μg/ml. SRBC-ME (Con A), however, did not affect RRBC rosette formation even at higher concentrations. RRBC-ME (Con A) inhibited RRBC rosette formation. 25 μg/ml of RRBC-ME (Con A) caused a 50% inhibition of RRBC rosette formation, but did not affect SRBC rosette formation. RRBC-ME (Con A) pretreated with guinea pig thymocyte extract did not inhibit rosette formation between RRBC and guinea pig T cells. From these physico-chemical studies it is suggested that the ligand extracted from erythrocytes membranes and effecting T cell rosette formation might be a glycoprotein.View full abstractDownload PDF (1216K) -
Shinichi Ito, Hironao MomoiArticle type: Article
1979 Volume 28 Issue 1 Pages 31-39
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSince animal and human experiments have shown insulin impurities to be highly immunogenic causing the formation of IgG antibody, we studied the allergenic potency of the three components of crystalline bovine insulin (a-, b-component and specially separated (SS)-Insulin) and determined the immunologic properties of IgE antibodies by means of PCA reactions. In rats immunized with a-component in combination with Bordetella pertussis and A1(OH)_3, gel, high levels of specific IgE antibodies were demonstrated, while SS-Insulin produced almost no specific IgE antibodies. Specific IgE antibodies against a-component cross-reacted with b-component and to a lesser degree with SS-Insulin. B-component specific antibodies cross-reacted with a-component and to a lesser degree with SS-Insulin. In PCA inhibition tests, the inhibitory effect of SS-Insulin was found to be markedly lower than that of either a-component or b-components, indicating that the PCA reaction is allergen-specific and that SS-Insulin is less immunoreactive than the other two components.View full abstractDownload PDF (718K) -
Mitsuru Furukawa, Tsugio Nakazawa, Setsuo Kobayashi, Kumiko SatoArticle type: Article
1979 Volume 28 Issue 1 Pages 40-47
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESS"Konnyaku asthma", primarily indigenious to Japan, is an occupational disease caused by inhalation of a dust called "Maiko". The dust is a by-product of the milling of the tuberous roots of Amorphophalus konjac, used to produce "konnyaku", a grey, jelly-like foodstuff, much used by the Japanese people. We have already reported that Ag40, an antigen precipitated from the water soluble fraction of "Maiko" by 40% saturated ammonium sulfate, had the most potent reactivity against the reagin of konnyaku asthmatic patients. In this work, Ag40 was further fractionated using 15% polyacrylamide gel electrophoresis into four fractions. One of these, designated Ag40D-2, elicited the most intensive reaction in the PK test. Reelectrophoresis of Ag40D-2 showed one band which stained with Amido black 10B and slightly stained with PAS. SDS-polyacrylamide gel electrophoresis of Ag40D-2 revealed the molecular weight of the antigen to be about 24 thousand. Ag40D-2 was composed of sixteen amino acids. Half-cystine, tryptophan and hexosamine, however, were not detected in it. The ratio of acidic amino acids to basic amino acids was 3.7 to 1.View full abstractDownload PDF (1496K) -
Article type: Appendix
1979 Volume 28 Issue 1 Pages 48-49
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1979 Volume 28 Issue 1 Pages 51-
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (285K) -
Article type: Cover
1979 Volume 28 Issue 1 Pages Cover3-
Published: January 30, 1979
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (173K)
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