Serum anti-Dermatophagoides farinae specific IgE (specific IgE) and total IgE were measured monthly or bimonthly during a period of one to four years in sixty-two mite sensitive asthmatic children from 2-13 years of age. The clinical course was faborable in more than 50% of children under 5, and all over 6, years, when their seasonal fluctuations in serum specific IgE levels were shown. On the other hand, the clinical course was unfavorable in most children under 5, and all over 6, years, when their serum specific IgE levels showed irregular fluctuation, although a similar pattern of fluctration was also observed in about 40% of children over 6 years with a favorable course. In almost all cases with regular seasonal fluctuation in serum specific IgE levels, a similar synchronous pattern of fluctuation in serum total IgE levels, half shown. However, among asthmatic children with irregular fluctuation in serum specific IgE levels, half showed irregular, and the other half regular, seasonal fluctuation in serum total IgE levels. In children over 6 years old with an unfavorable clinical course, the fluctuation in both specific and total IgE levels was irregular. No correlation existed between clinical severity and fluctuations in either the pattern or level of serum total IgE, or in the serum specific IgE levels There was also no appreciable relationship between fluctuation in specific IgE levels and method of treatment. Therefore, it might be suggested that fluctuations in specific IgE levels of these asthmatic children were more affected by individual intrinsic factors than extrinsic (enviromnental) factors.
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