Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
Volume 28, Issue 10
Displaying 1-11 of 11 articles from this issue
  • Article type: Cover
    1979 Volume 28 Issue 10 Pages Cover4-
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Article type: Cover
    1979 Volume 28 Issue 10 Pages Cover5-
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (34K)
  • Article type: Bibliography
    1979 Volume 28 Issue 10 Pages Misc2-
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Isamu Kimura, Shoso Yamamoto, Takuso Yamura
    Article type: Article
    1979 Volume 28 Issue 10 Pages 717-722
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    In vitro antigen-induced release of eosinophil chemotactic factor of anaphylaxis (ECF-A) -like substance was studied using skin slices from guinea pigs sensitized with egg albumin. 500μm thick slices of abdominal skin were incubated in the antigen solution at 37℃ for 20 min. Assay of eosinophil chemotactic factor in the supernatants of the reaction mixtures was carried out using an eosinophil suspension from guinea-pig. The supernatants produced significant migration of the eosinophils through the Millipore filter, and significant histamine release was also observed in the suspernatants. The release of the eosinophil chemotactic factor was Ca^<++>-dependent, and the factor was dialysable. These facts suggest that the eosinophil chemotactic factor in the supernantants may be ECF-A-like substance and histamine was observed in in vitro anaphylactic reactions in guinea-pig skin.
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  • Tomohiko Ohno, Yoshiki Kawabata, Nobuhiko Tamaki, Jiro Inui, Kikukazu ...
    Article type: Article
    1979 Volume 28 Issue 10 Pages 723-731
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Human ultrafiltrated leukocyte extracts (ULE) were separated on Sephadex G-10 column chromatography, and the effect of their fractions on leukocyte random locomotion was investigated by the modified Boyden chamber method. The fraction of the second optical density peak (OD-2) has significant leukocyte random locomotion inhibition activity. Furthermore, the OD-2 peak of ultrafiltrated mononuclear cell extracts (U-MN-E) has more intensive optical density and more significant cell locomotion inhibition activity than that of ultrafiltrated PMN extracts (U-PMN-E), suggesting that inhibition activity, which was effective on human PMN, monomuclear cells and guinea pig PMN, may be derived from mononuclear cells and/or platelets. It is suggested that the active component has a direct action on the locomotion of cells without interaction with mononuclear cells and/or lymphokines.
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  • Futoshi Yamazaki, Mizuo Mizuno, Takao Shida, Takaharu Shimizu
    Article type: Article
    1979 Volume 28 Issue 10 Pages 732-737
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    The atomospheric dispersion number of the causative pollen grains of Japanese cedar pollinosis has a sharp fluctuation with the year and the number of the patients varies conspicuously as well. In this study, the actral dispersed pollen numbers were compared with the results of detailed examination of meteorological factor on the season of differenciation of flower buds for the aim of earlier prediction of the dispersion number of Cryptomeria japonica (C. japonica) pollen grains.The results were as followa; 1) The total pollen dispersion number of C. japonica increased markedly for the next year when the mean temperature in July was high 1℃ or more compared with the monthly normals. 2) In case the mean temperature in July was higher than the monthly normals within 1℃, the total pollen dispersion number of C. japonica increased for the next year, while it sharply decreased when the mean temperature was lower than the monthly normals. 3) The total pollen disperision number of C. japonica increased remarkably for the next year if the mean temperature in July for the year when the total pollen dispersion number was low, was higher than the monthly normals within 1℃. 4) The total pollen dispersion number had any correlation neither with the precipitation in July for the previous year nor with the rainy conditions during the season of the pollen dispersion. It was, therefore, concluded from the above-mentioned investigation that the mean temperature in July had a decisive influence upon the total number of pollen dispersion of C. japonica for the next year.
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  • Shotaro Mitsui, Morio Sudo, Takeshi Bando, Kisaburo Akasaka
    Article type: Article
    1979 Volume 28 Issue 10 Pages 738-746
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    This study is based on 250 asthmatics, 134 males and 116 females, 119 under 15 and 131 over 16 years of age, who received nonspecific therapy in 19 medical facilities in the North-east district of Japan. 1) Gold therapy was used in 44 cases over 29 years of age. The improvement was 66% in paroxysmal type and 25% in chronic type. The improvement was 20.5% by 3 month and 47.7% by 6 month reatment. 2) Vaccination therapy was used in 33 cases. The improvement was 27.3% by 3 month and 45.5% by 6 month treatment. Further, 64% of patients under 15 years of age, 88% of mild asthma, 54% of paroxysmal type and 67% of atopic type were improved. 3) Histamine mixed γ-globulin therapy was used in 34 cases. The improvement was greater in mild attack (91%) and in atopic type (81%). Yet, there was no difference between paroxysmal type (69%) and chronic type (75%) in the improvement rate. The improvement by 3 month treatment was 64.7%, and no further improvement was noted by more than 3 month treatment. 4) Disodium cromoglycate was administered in 44 cases. The improvement was 90% in mild asthma, 71% in paroxysmal type, 86% in atopic type and 71% in cases under 15 years of age. The improvement by 3 month treatment was 47.7%, and no difference in improvement between 3 month and more than 3 month treatment was found. 5) Disodium cromoglycate in combination with hyposensitization therapy was used in 78 cases. The improvement was 88% in mild asthma, 84% in moderate severe asthma, 84% inparoxysmal and 88% in atopic type. Further, the improvement by 3 month treatment was the highest (66.7%) in contrast to the other therapies.
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  • Tetsuo Horiuchi
    Article type: Article
    1979 Volume 28 Issue 10 Pages 747-757
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Venous blood lymphocytes from normal donors and patients with autoimmune diseases were UV-irradiated and 10μCi/ml ^3H-TdR and 10^<-2>M hydroxyurea was immediately added to determine unscheduled DNA synthesis by incorporated radioactivity. Between T and B cells from normal subjects, there was no difference in DNA repair, while in those from T and B cell type CLL it was markedly decreased. In most SLE patients and some patients with RA, PSS and malignant lymphoma, DNA repair was moderately decreased. Autoradiographic grain count distribution on lymphocytec nuclei of SLE patients showed a slightly lower count than normal. Serum from SLE patients showed no inhibitory effect on the repair of lymphocytes from normal subjects.
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  • Katsuji Nakamura
    Article type: Article
    1979 Volume 28 Issue 10 Pages 758-773
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Serum anti-Dermatophagoides farinae specific IgE (specific IgE) and total IgE were measured monthly or bimonthly during a period of one to four years in sixty-two mite sensitive asthmatic children from 2-13 years of age. The clinical course was faborable in more than 50% of children under 5, and all over 6, years, when their seasonal fluctuations in serum specific IgE levels were shown. On the other hand, the clinical course was unfavorable in most children under 5, and all over 6, years, when their serum specific IgE levels showed irregular fluctuation, although a similar pattern of fluctration was also observed in about 40% of children over 6 years with a favorable course. In almost all cases with regular seasonal fluctuation in serum specific IgE levels, a similar synchronous pattern of fluctuation in serum total IgE levels, half shown. However, among asthmatic children with irregular fluctuation in serum specific IgE levels, half showed irregular, and the other half regular, seasonal fluctuation in serum total IgE levels. In children over 6 years old with an unfavorable clinical course, the fluctuation in both specific and total IgE levels was irregular. No correlation existed between clinical severity and fluctuations in either the pattern or level of serum total IgE, or in the serum specific IgE levels There was also no appreciable relationship between fluctuation in specific IgE levels and method of treatment. Therefore, it might be suggested that fluctuations in specific IgE levels of these asthmatic children were more affected by individual intrinsic factors than extrinsic (enviromnental) factors.
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  • Article type: Appendix
    1979 Volume 28 Issue 10 Pages 774-777
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
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  • Article type: Cover
    1979 Volume 28 Issue 10 Pages Cover6-
    Published: October 30, 1979
    Released on J-STAGE: February 10, 2017
    JOURNAL FREE ACCESS
    Download PDF (156K)
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