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Volume 29, Issue 1
Displaying 1-11 of 11 articles from this issue
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Article type: Cover
1980 Volume 29 Issue 1 Pages Cover1-
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (29K) -
Article type: Cover
1980 Volume 29 Issue 1 Pages Cover2-
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (29K) -
Article type: Bibliography
1980 Volume 29 Issue 1 Pages Misc1-
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (277K) -
Toshisada Kimura, Hiroko Tutumi, Masamichi Tazawa, Akihiro MorikawaArticle type: Article
1980 Volume 29 Issue 1 Pages 1-9
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe double injection test was used to titrate the blocking antibody. 1) The blocking antibody titer range, measured by the direct double injection test, was between 1:1 to 1:1024 in 72 asthmatic cases. 2) The results of blocking antibody titers that were carried out on 18 asthmatic patients by the direct and the direct double injection test disclosed that the latter is superior to the formor.3) The blocking antibody titers obtained by the direct double injection and the indirect double injection test on 7 asthmatic children were almost equal. 4) The blocking antibody titers obtained by the indirect double injection and the absorption test on 5 asthmatic children were almost equal. These results indicate that measurement of blocking antibody by the double injection test is easy to perform and offers clinical advantages.View full abstractDownload PDF (1183K) -
Shuji SuzukiArticle type: Article
1980 Volume 29 Issue 1 Pages 10-15
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe establishment of an animal model, with which the systemic symptoms and cutaneous signs of human penicillin (Pc) allergy (Type I) can be reproduced by a Pc preparation, led us to perform in vitro and in vivo studies to analyze the antigenicity of a Pc preparation. Guinea pigs were immunized with PcG-Ascaris extract conjugate in Al(OH)_3 gel. In tracheas or lungs removed from guinea pigs that had been passively sensitized with the antiserum obtained from immunized animals, anaphylactic contractions or histamine releases were induced in vitro by addition of a PcG preparation. These results show that the PcG preparation has sufficient eliciting power to evoke anaphylactic reactions. The substances responsible for the antigenicity are thought to be macromolecular, since removal from the preparation of the fraction containing macromolecular impurities by the gel filtration reduced the antigenicity. As a discrepancy existed between the reactivity of the sensitized tracheas against BPO-protein and that against the PcG preparation, antigenic determinants other than benzylpenicilloy may be mainly responsible for the positive anaphylactic reactions.View full abstractDownload PDF (790K) -
Shuhei Takemura, Tadahiro Hotta, Naoyuki Matsumura, Koichi Watanabe, T ...Article type: Article
1980 Volume 29 Issue 1 Pages 16-20
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA decrease in the hemolytic complement level due to activation of the classical complement pathway when samples are exposed to a cold environment has been designated "cold activation of complement (CAC)" in vitro. CAC has been observed in chromic liver diseases in which about 50% of the patients revealed serum cryglobulin, while the rest of the patients had no detectable cryoglobulin. To demonstrate the mechanism of CAC, and to investigate the factor in sera without cryoglobulin, the anticomplement activity assay was performed at 4℃ or at 37℃. In all cases with CAC, Irrespective of the presence or absence of cryoglobulin, the sera showed much higher anticomplement activity at 4℃ than that at 37℃. Our findings suggest that the factors responsible for CAC are; (1) cryoglobulin, and (ii) in patients without cryoglobulin, a soluble cryoglobulin-like substance.View full abstractDownload PDF (683K) -
Yoshiaki Inagaki, Akira Kanai, Masanori Yamada, Masami Yoshida, Masano ...Article type: Article
1980 Volume 29 Issue 1 Pages 21-29
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn 118 children with bronchial asthma, inhalation tests with histamine and house dust extract were carried out 1) The levels of respiratory threshold of histamine were less than 78×2^7μg in 97% of the asthmatics and 78×2^7μg or more in non-asthmatics. 2) In the inhalation tests with house dust extract, comparing the positive with the negative group (p<0.005), the higher the decreases of FEV_<1.0> (r=0.42, p<0.005), the lower the levels of the respiratory thresholds of histamine.3) Regarding the late response in the inhalation rests with house dust extract, lower levels of respiratory thresholds of histamine were revealed in the positive than the negative group (0.01<p<0.025). Regarding the early response, the greater the decreases of FEV_<1.0>, the higher the frequency of positive responses on the late response examined (0.01<p<0.025). 4) In patients with earlier onset of asthma (r=0.28, 0.01<p<0.025) and longer periods of asthma (r=0.34, p<0.005), lower levels of respiratory thresholds of histamine were obtained. 5)Severe asthmatics showed lower levels of respiratory thresholds of histamine as compared to moderate or mild asthmatics (p<0.005). 6) The levels of respiratory threshold of histamine were not remarkably affected by hyposensitization with house dust extract nor did they correlate with the clinical course.View full abstractDownload PDF (1046K) -
Yasuo Yui, Takao ShidaArticle type: Article
1980 Volume 29 Issue 1 Pages 30-40
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBasic RAST studies using polyacrylamide gel were carried out to detect specific IgE antibody to sugi (Japanese cedar) pollen antigen. This method was applied for polysaccharide antigen. 1) Experimental error was within 10% and nonspecific trapping of radioactivity seemed to be smaller than in the paper disc method. 2) There was a close correlation between the RAST results when results obrained by thepolyacrylamide gel method and the paper disc method were compared. The correlation coefficient was 0.95. This was highly significant (p<0.01). These results indicate that antigen-containing polyacrylamide gel is useful as a solid phase for RAST. 3) Polyacrylamide gel was applied to detect IgE antibody to mannan extracted from Candida albicans. Mannan was trapped in gel. High radioactivity was obtained by RAST in only one of 10 cases. The results of RAST to mannan were correlated with the results of the PK reaction. This suggests that mannan may not be major allergen of Candida Albicans.View full abstractDownload PDF (1297K) -
Mitsuru FurukawaArticle type: Article
1980 Volume 29 Issue 1 Pages 41-47
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAllergic activities of four purified antigens of "Maiko", Ag40D-1, Ag40D-2, Ag40D-3 and Ag40D-4, were compared using the PK test and RAST in three konnyaku asthmatic patient sera. The PK test showed the following strong activity, Ag40D-2>Ag40D-3≧Ag40D-4>Ag40D-1. The RAST direct test showed different results in the 3 patient sera, while the RAST inhibition test showed that Ag40D-3>Ag40D-4>Ag40D-1>Ag40D-2, in 2 sera. One serum showed. Ag40D-4>Ag40D-3>Ag40D-1>Ag40D-2. Also the RAST inhivition test and the in vitro neutralization test using the PK test of Ag40D-2 and Ag40D-3 was done under same conditions. The results were the same; Ag40D-3 showed stronger activity than Ag40D-2.View full abstractDownload PDF (801K) -
Article type: Appendix
1980 Volume 29 Issue 1 Pages 48-
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (309K) -
Article type: Cover
1980 Volume 29 Issue 1 Pages Cover3-
Published: January 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (217K)
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