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Volume 29, Issue 11
Displaying 1-11 of 11 articles from this issue
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Article type: Cover
1980 Volume 29 Issue 11 Pages Cover7-
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (29K) -
Article type: Cover
1980 Volume 29 Issue 11 Pages Cover8-
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (29K) -
Article type: Bibliography
1980 Volume 29 Issue 11 Pages Misc3-
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (238K) -
Masahide Minoda, Masayoshi Nishida, Atsushi Horiuchi, Junichi IwamuraArticle type: Article
1980 Volume 29 Issue 11 Pages 935-940
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA subpopulation of mouse thymus and spleen lymphocytes can bind with autologous erythrocytes forming rosettes. The number of this autologous rosette forming cells(ARFC)is abnormally high in the spleens of nude mice(211 per 10^4 cells), and it is suggested that ARFC may be T-cell precursors. We report here the effect of immunopotentiators, such as thymus extract, levamisole and methyl-B_<12> on the number of ARFC in the spleens of nude mice. Control nude mice treated with BSA showed of ARFC: 198(n=4)per 10^4 cells. Spleen cells treated with anti-Thy-1+C or anti-BAT+C, before rosette assay, showed a decrease in number of ARFC: 145 and 62. Thymus extract treated group showed decrease in numbers of ARFC: 52 and maximal decrease were obtained with a dose of 33 mg/kg at 48 hr after treatment. Maximal decrease of ARFC in the levamisole and the methyl-B_<12>-treated groups, 79 and 94, were obtained with a dose of 1.25 mg/kg, 6.25 mg/kg at 24 hr after treatment respectively. These results suggested that ARFC belong to immature T-cell subset, and thymus extract, levamisole and methy-B_<12> can mature the T cell precursors.View full abstractDownload PDF (882K) -
Masaaki Honda, Tsuyoshi Sakane, Katsutoshi Moriyama, Tokugoro Tsunemat ...Article type: Article
1980 Volume 29 Issue 11 Pages 941-949
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDetermination of human peripheral blood lymphocyte subpopulations was performed by the use of mixed rosette assay, by which every lymphocyte is able to be classified into a sheep erythrocyte(SRBC)rosette-forming cell or T cell population, an immunobead rosette-forming cell or B cell population, a both cell population and a null cell population. SRBC rosette-negative lymphocytes have been demonstrated to be divided into two populations by direct immunofluorescence; those with the presence of membrane-intrinsic or membrane-stable immuno-globulin(Ig)molecules, and those with membrane-labile IgG molecules which are removed by the incubation at 37℃ before staining. Although immunobeads could react with membrane-stable Ig molecules, but not either with membrane-labile IgG molecules or with Fc receptors, the preincubation of lymphocyte preparations at 37℃ was necessary for the precise determination of T cells and null cells. That is, immune complex or any Ig that might be passively absorbed to the Fc receptors of some of the T cells could inhibit the rosette-formation with SRBC. So far, our study with this mixed rosette assay method disclosed that the mean values and their standard errors of T cells, B cells, both cells, and null cells in peripheral blood lymphocytes obtained from 20 normal subjects were 71.2±2.4%, 12.3±1.1%, 2.3±0.4%, and 14.2±2.1%, respectively. Further study was done in order to well define the characteristics of null cell population. This populaiton lacked the readily detectable C3 receptors which are present of B cells, and every null cell had dense receptors for the Fc portion of IgG. Thus, it seems that null cells determined in this study are equivalent to L lymphocytes.View full abstractDownload PDF (1619K) -
Morihiro Ohara, Minoru Nanamiya, Naoe Yoshida, Shuko Suzuki, Kozo Onam ...Article type: Article
1980 Volume 29 Issue 11 Pages 950-955
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn vitro production of pregnancy-associated α_2-glycoprotein(PAG)from peripheral lymphocytes and lymphocytes or granurocytes in joint fluid of rheumatoid patients were studied. Amounts of PAG produced from 2×10^6 cells/ml cultured with estrogen at a concentration of 4 mg/ml were measured by radioimmunoassay. PAG on the cells estimated by binding of ^<125>I-labeled anti-PAG antibody to the cells and estimation of PAG excreted into the culture medium was by solid phase radioimmunoassay. The mean amount of PAG produced in the culture medium from peripheral lymphocytes of 3 normal subjects was 4.5 units, whereas those that produced in the case of 3 rheumatoid patients was 6.1 units. The PAG was produced similarly from lymphocytes and granulocytes in joint fluid of rheumatoid patients. The amounts were 4.0 units in the case of lymphocytes and 4.5 units in granulocytes.View full abstractDownload PDF (682K) -
Tsugio Nakazawa, Masahito Inazawa, Setsuo KobayashiArticle type: Article
1980 Volume 29 Issue 11 Pages 956-961
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSImmunological studies were performed on a pair of identical twins, 23-year-old sister; one has konjac bronchial asthma and the other is non-asthmatic who has been exposed to "Maiko", an allergenic substance of konjac bronchial asthma, for past 19 years. 1) Asthmatic twin showed manifest higher airway sensitivity than non-asthmatic did in acethylcholine inhalation test. 2) Sightly but not significantly lower threshold were observed in the asthmatic than that of the non-asthmatic by the intracutaneous test used Ag90. 3) RAST score against Ag90 and Ag40 were 1, 1 respectively in the asthmatic one. These of the non-asthmatic is 1, 0 respectively. 4) IgE globulin was elevated in both cases; 3001 IU in the asthmatic, 1829 in non-asthmatic twin. 5) IgG antibody detected by heterologous guinea-pig PCA reaction showed slight difference in two cases: 1:20 in asthma twin, 1:10 in the non-asthmatic twin. Between these identical twins, there was manifest difference of airway sensitivity, but there was not so manifest difference of ability of antibody production. These results suggest that multifactorial conditions may be needed to induce clinical asthma.View full abstractDownload PDF (713K) -
Noriaki Shinomiya, Junichi YataArticle type: Article
1980 Volume 29 Issue 11 Pages 962-969
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to clarify the regulatory function of T-cells from myasthenia gravis(MG)in the antibody production against acetylcholine receptor antigen(AchR), thymic B-cells and T-cells from MG and peripheral blood(Pbl)B-cells and T-cells from MG or healthy adults in various combinations were cultured in the presence of AchR, and the production of anti-AchR antibody in culture supernatant, antibody forming cells(AFC)and immunoglobulin producing cells(Ig cells)from each culture were estimated. Thymic T-cells from MG helped anti-AchR antibody production from both thymic and Pbl B-cells. No such helper function was observed in Pbl T-cells either from MG or healthy individuals. The helper activity of thymic T-cells seemed to be related to the histology of the thymus. It was clearly demonstrated in the thymus with prominent lymphofollicles but not in the case of epithelial thymoma. The production of antibody from the combination of thymic B and T-cells of MG was suppressed by Pbl T-cells from healthy individuals. Autologus or allogenic Pbl T-cells from MG did not show such suppressor effect, which indicated that the suppressor T-cells in MG patients were defective.View full abstractDownload PDF (1102K) -
Yoshiro Imada, Yukihiro Ago, Hideki Teshima, Shoji Nagata, Yoshihiko M ...Article type: Article
1980 Volume 29 Issue 11 Pages 970-975
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPlasma histamine levels were assayed in three groups of allergic patients and in a healthy control group by the high-speed liquid chromatographic method. In the bronchial asthma group, the mean value of plasma histamine levels was 2.0 ng/ml, and in the urticaria group, it was 2.3 ng/ml. In the control group, the mean value was 1.1 ng/ml. The mean value of the two patient groups mentioned was significantly higher than that of the control group. In the third patient group, the allergic rhinitis patients, the mean value of plasma histamine levels was 1.3 ng//ml. There was no significant difference between the allergic rhinitis group and the control.The relationship between plasma histamine levels and serum IgE titers was studied in the bronchial asthma group. In the high IgE titer group(IgE>700 IU/ml), the mean value of plasma histamine was significantly higher than in the low titer group(400 IU/ml≧IgE). Furthermore, positive significant correlation was found between plasma histamine levels and log IgE titers. These results suggest that IgE titer is one of the factors that influence the plasma histamine levels in the asymptomaic state of bronchial asthma.View full abstractDownload PDF (768K) -
Article type: Appendix
1980 Volume 29 Issue 11 Pages 976-979
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (294K) -
Article type: Cover
1980 Volume 29 Issue 11 Pages Cover9-
Published: November 30, 1980
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (239K)
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