Japanese Journal of Allergology

[title in Japanese]

Article type: Cover
1980 Volume 29 Issue 5 Pages Cover22-
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.Cover22

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[title in Japanese]

Article type: Cover
1980 Volume 29 Issue 5 Pages Cover23-
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.Cover23

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[title in Japanese]

Article type: Bibliography
1980 Volume 29 Issue 5 Pages Misc8-
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.Misc8

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CLINICAL PHARMACOLOGY OF THEOPHYLLINE : 2. Clinical Application of Theophylline pharmacokinetics

Yukio Horai, Takashi Ishizaki, Junzaburo Kabe, Makoto Watanabe

Article type: Article
1980 Volume 29 Issue 5 Pages 203-210
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.203

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The validity and predictability of theophylline pharmacokinetics obtained from the initial i.v. loading were examined for the optimization of oral theophylline therapy in 40 asthmatics and 7 congesve heart failure (CHF) patients. Based on individual disposition data, adjusted dosage regimens were undertaken for each patient and the predicted plasma theopylline concentrations were compared to those actually measured by a high pressure liquid chromatography (HPLC). No significant difference of the apparent volume of distribution was found between the two groups. However, the elimination half-life (17.4±1.7hr, mean±SEM) and plasma clearance (0.016±0.001l/kg/hr) in CHF patients differed significantly (p<0.01) from those of patients with uncomplicated bronchial asthma. Out pharmacokinetic data indicated that a loading dose of aminophylline (4.5-5.0mg/kg), followed by a maintenance dose (0.46 and 0.20mg/kg/hr, iv.infusion rate), is the recommended regimen for asthmatic and CHF patients (cardiac asthma), respectively. The predicted concentrations at steady-state for attaining the therapeutic range of 8-20μg/ml were consistent with the observed levels and the predicted ability for maintaining this therapeutic range was achieved in 74% of the examined patients. We conclude that for optimization of theophylline therapy, an understanding of the clinical pharmacokinetic principles is necessary and this approach may lead to more rational dosage regimen adjustments of theophylline.

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FUNDAMENTAL STUDY ON THE POTENTIATING ROLE OF MONOCYTES IN THE MITOGENIC RESPONSE OF T CELLS AND ITS APPLICATION TO CANCER PATIENTS

Yuuji Hinoda, Masayuki Arashi, Yasuo Moriya, Shigeru Takada, Akira Yac ...

Article type: Article
1980 Volume 29 Issue 5 Pages 211-216
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.211

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Fundamental studies on the effect of monocytes on mitogen induced T cell blastogenesis were carried out and its applicability for evaluating the monocyte function in cancer patients was examined. The response of T cells to PHA, Con A, and PPD was dependent on monocytes in that order. The response of T cells to a suboptimal dose (3μg/ml) was more dependent on monocytes than that to an optimal dose (15μg/ml). Allogeneic monocytes were as effective as autologous monocytes in potentiating T cell response to PHA. Co-culture experiments suggested that the monocyte function of potentiating T cell response to a suboptimal dose of PHA decreased in patients with gastric cancer.

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BEHCET'S DISEASE AND INFECTION ALLERGY : 2. Titer of Bacterial Agglutination and Immunopathological Findings of the Lesions

Fumio Kaneko, Manabu Sudo, Hiromi Hosono, Yusho Miura, Masaki Ohguchi

Article type: Article
1980 Volume 29 Issue 5 Pages 217-226
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.217

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We previously demonstrated the presence of strong reactivities in delayed hypersensitivity against streptococcal vaccines (Hollister-Stiers Lab., U.S.A.) including Lancefield's group D (St.D) in patients with Behcet's disease. In the present investigations, to study humoral immunity relating to bacteriae and immunopathological findings of the lesions have been made in 20 patients with Behcet's disease. The results obtained were as follows: 1) In the patients, serum titer of bacterial agglutination revealed relatively high against vaccines of St.vividans and St.faecalis composed of α- and γ-hemolytic St.D (Hollister-Stiers Lab.), while titers against vaccine of St.pyogenes (β-hemolytic group A) were low in comparison with normal controls. 2) High level of serum IgA was noticed in the patients and also IgD was high level in some cases. 3) Direct immunofluorescent technique using antiserum to St.D (bactoFA Streptococcus group D, Difco Lab., U.S.A.) showed specific fluorescence on surface of the ulcer in the oral and genital lesions and at infiltrates in and around the dilated capillaries of the cutaneous and occular lesions. Deposits of immunoglobulins and complement components were also found in some cases. These results may suggest that immunological reactions against the substance related to St.D are present in the various lesions of patients with Bechcet's disease.

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EFFECT OF CHINESE DRUG ("SHOHSEIRYU-TO") ON NASAL ALLERGY : Part 1. The Changes of IgE, Histamine and cAMP Levels in Blood Induced by Treatment with "SHOHSEIRYU-TO"

Kazuo Kuriyama, Kohtaro Baba, Yuji Okusawa, Ichiro Furuuchi

Article type: Article
1980 Volume 29 Issue 5 Pages 227-235
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.227

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Controlled studies in nasal allergy have shown that an on average, 70% of the patients improved after specific or non-specific hyposensitization. We orally administered "SHOHSEIRYU-TO" to 29 patients with house dust nasal allergy who were unresponsive to specific hyposensitization. The dosage was 5.0g per day and was administered for 3 consecutive weeks. The drug efficacy rate was higher in subjective symptoms than in objective signs. Serum IgE levels ranged from 216 to 6060 unit/ml and 303 to 4920 unit/ml with a mean of 2767.1±1973.4 and 1642.2±1183.5 unit/ml, respectively. Mean±SD of relative concentration by RAST scores was 2.0±1.4 score/ml and 1.0±0.9 score/ml. There was a significant difference between before and after administration (p<0.01) both in IgE levels and RAST scores in sera. Mean of blood histamine levels and plasma cAMP levels before administration were ranged from 0.022μg/ml to 0.082μg/ml and 0.9p mol/ml to 22.4p mol/ml with a mean of 0.0482±0.0178μg/ml and 6.96±6.18p mol/ml, and their levels after administration were ranged from 0.014μg/ml to 0.074μg/ml and 1.0p mol/ml to 21.8p mol/ml with a mean of 0.0349±0.0138μg/ml and 11.35±6.68p mol/ml, respectively. Decrease of histamine level in blood and increase of cAMP level in plasma were significantly correlated (p<0.01). Although the mechanism of the Chinese drugs underlying the clinical effect is not completely clarified, these results suggest that some of the Chinese drugs would be effective in nasal allergy.

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INFLUENCE OF CATALYTIC SCAVENGERS OF OXYGEN INTERMEDIATES ON RELEASE OF LYSOSOMAL ENZYMES AND PHAGOCYTOSIS : Investigation by Dose Response on the Presence of New Pathways Oxygen Intermediates

Yukie Niwa

Article type: Article
1980 Volume 29 Issue 5 Pages 236-242
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.236

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The extent of non-lethal release of lysosomal enzymes from phagocytosing neutrophils is suppressed by an increase in oxygen intermediates generated by stimulated neutrophils. We report that catalytic scavengers quenching these oxygen by-products improve the decreased enzyme release and that the degree of improvement is dependent on the scavenger types and on the dose response. The effects of 5 catalytic scavengers of the oxidative metabolites on the secretion of lysosomal enzymes and phagocytosis were assessed using the dose response by incubating normal human neutrophils with zymosan, ^<14>C-inulin and various ^1O^2 alone raised the release of α-mannosidase, β-glucuronidase and lysozymes in accordance with their concentrations, without enhancing the secretion of LDH, and lowered phagocytosis inversely proportional to their concentrations. Mannitol which quenches OH alone was slightly effective on the increase of these enzymes and decrease of phagocytosis, whereas catalase which scavenges the H_2O_2 was almost ineffective. On the other hand, superoxide dismutase (SOD) which converts O_2-to H_2O_2, at low concentrations (150-300U/ml) rather inhibited, while at higher concentration (above 600U/ml), it potentiated, enzyme release. Superoxide dismutase at low concentrations enhanced, while at higher concentrations it lowered phagocytosis.

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POLYETHYLENE GLYCOL PRECIPITATION AND GEL FILTRATION TECHNIQUE FOR DETECTING COMPLEXED IgE

Susumu Furukawa, Masaharu Tsuda, Chiyuki Abe, Keiko Maeda

Article type: Article
1980 Volume 29 Issue 5 Pages 243-246
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.243

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Polyethylene glycol (PEG) precipitation and the gel filtration technique were used to detect complexed IgE. The precipitation rate of ^<125>I-IgE and ^<125>I-aaggregaated IgE with different PEG concentration were measured. The precipitation rate of ^<125>I-IgE with 4% PEG was low, but that of ^<125>I-aggregated IgE was very high. Serum from a patient with lupoid hepatitis complicated by insect allergy was fractionated by Sephacryl S-300 gel filtration at neutral pH. Two peaks of IgE in monomeric and complexed or aggregated form were demonstrated. The precipitation rate of monomeric IgE with 4% PEG was low but that of complexed or aggregated IgE was very high. These results suggest that circulating complexed IgE may exist in some patients and that the fraction including complexed IgE can be measured by the 4% PEG precipitation technique.

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[title in Japanese]

Article type: Appendix
1980 Volume 29 Issue 5 Pages 247-250
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.247

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[title in Japanese]

[in Japanese]

Article type: Article
1980 Volume 29 Issue 5 Pages 251-
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.251

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[title in Japanese]

Article type: Appendix
1980 Volume 29 Issue 5 Pages 253-256
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.253

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[title in Japanese]

Article type: Cover
1980 Volume 29 Issue 5 Pages Cover24-
Published: May 30, 1980
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.29.Cover24

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