Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 30, Issue 1
Displaying 1-13 of 13 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1981 Volume 30 Issue 1 Pages Cover1-
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Cover1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1981 Volume 30 Issue 1 Pages Cover2-
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Cover2
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1981 Volume 30 Issue 1 Pages Misc1-
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Misc1
    JOURNAL FREE ACCESS
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  • EFFECT OF NEURAMINIDASE ON ANAPHYLACTIC CONTRACTION OF GUINEA PIG TAENIA COLI : (II) Mechanisms of the Inhibitory Actions of Neuraminidase on Anaphylactic Contraction
    Kazuhiro Shichinobe, Tadao Okamura, Kazumasa Nakama
    Article type: Article
    1981 Volume 30 Issue 1 Pages 1-7
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.1
    JOURNAL FREE ACCESS
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    The modes of the inhibitory actions of neuraminidase, phosphplipase A and C on anaphylactic contraction of guinea pig taenia colis were investigated by means of the Magnus apparatus and enzyme labeled antibody method. Reaction sites of the peroxidase labeled antibody and antigen located on the surface of the tissues from sensitized taenia coli. After treatment with neuraminidase, the anaphylactic contraction disappeared but the histamine contraction was still observed. After the treatment with neuraminidase, no reaction sites on the tissue surface existed, while after phospholipase A and C treatment, they remained observable. The above described results were discussed, whether it relates movement of Ca^++, or not on cell membrane.
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  • A CASE OF ULCERRATIVE CILITIS TREATED SUCCESSFULLY WITH N-(3', 4'-DIMETHOXYCINNAMOYL) ANTERANILIC ACID(N'-5')
    Motohiro Kurosawa, Toshikazu Nemoto, Tetsuji Tanaka, Ryuzo Fueki, Sets ...
    Article type: Article
    1981 Volume 30 Issue 1 Pages 8-15
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.8
    JOURNAL FREE ACCESS
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    A 23-year-old female was diagnosed as an ulcerative colitis case (proctitis type) based on her present history, barium enema, sigmoidoscopy and so on. In the immunological study, serum IgA and CH50 levels were slightly lowered from normal levels. The percent ratio of T and B cells in peripheral blood lymphocytes was normal and PPD and PHA skin tests were normal positive. Skin tests to several inhalant and food antigens, significant release was observed with only milk and house dust antigens. This histamine release was inhibited with N-5' and DSCG pre-treatment, but the inhibition per cent with N-5' was greater than that with DSCG. Although they were not improved with salicylazosulfapyridine and betamethasonum suppository treatment, clinical symptoms were improved following N-5' administration. Thereafter, with N-5' treatment exclusively, her condition stabilized without the medication of salicylazosulfapyridine and the ulcer od rectum found by sigmoidoscopy disappeared. The patient was also complicated by pustulosis intestinal problems in disease. After the administration of N-5', the level of serum IgA remained lower while that of CH50 returned to normal. The skin test with house dust antigen only showed positive reaction, but no significant histamine release from peripheral leukocytes was observed. Our observations suggest that, in this case, the immediate allergic reaction to milk antigen might play some role in development of the colitis.
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  • ASPIRIN HYPERSENSITIVITY IN NINE CASES AND CROSSREACTIVITY WITH ARTIFICIAL DYES-CHILD ASTHMA AND CHRONIC URTICARIA
    Yukio Kitajima, Makoto Ushiyama
    Article type: Article
    1981 Volume 30 Issue 1 Pages 16-24
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.16
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    In this report, patients 8 to 15 years old were taken up. Out of 27 cases which 18 cases which 18 cases were admitted to the hospital for asthma. 7 cases of urticaria and 2 cases with asthma and urticaria who did not show benefit to antihistamine; 9 aspirin sensitive child patients have been reported through identification of etiologies by reduced 20% or greater fall in FEV_1.0 or PFR, or urticaria following inhalation or sublingual testing with aspirin and artificial dyes. Six out of nine patients were sensitive to aspirin and tartrazine, and one patient was sensitive to aspirin, tartrazine and blue 2. Three patients have suffered from asthma, four patients from urticaria and one patient from asthma and urticaria. Four patients had the history of drug eruption and another four patients had aspirin sensitive family background. Four patients have been worried with nasal symptoms, but had no nasal polyposis. Eosinophiles in the nasal smear were found in 5 cases out of 7 cases. Blood eosinophilia was found in 2 cases. IgE levels in the serum were within normal range. After avoidance of aspirin and artificial dyes, the above mentioned symptoms of these patients have been well controlled.
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  • GRANULE LYSIS OF HUMAN EOSINOPHIL BY THE INTERACTION WITH IMMUNE COMPLEXES : Electron Microscope Study
    Yoshiharu Ogami
    Article type: Article
    1981 Volume 30 Issue 1 Pages 25-32
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.25
    JOURNAL FREE ACCESS
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    In order to elucidate the specific function of eosinophil, the reaction of specific human eosinophilic granules to various immuno-complexes was investigated systematically by electron microscope. The eosinophils were incubated with immuno-complexes such as IgE, IgG, IgA, IgM, C3 and albumin at 37℃ for 1 hour. Characteristic changes were observed in IgE, IgG and C3 immuno-complex. Morphologically, coarsening of granular matrix, appearance of tubular structures and vacuolation, namely granule lysis, were characteristic. It may be considered that these morphological changes are relative to the release of granular content, which are packed in tubular structures. As content decreases, the tubular structures will appear and finally vacuolation will be performed. If the supposition that the reaction of eosinophil to IgE complex specifically is correct, it would be very convenient in elucidating the function of complex. It the receptor for IgE, IgG and C3 exist in eosinophil, the mechanism of this response is fully explained. However, further studies are indispensable because the existence of receptors for IgE unlike those for IgG and C3 are now in dispute.
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  • EFFECT OF METOPROLOL, A NEW β_1-SELECTIVE BLOCKING AGENT, ON PULMONARY FUNCTION OF PATIENTS WITH BRONCHIAL ASTHMA : Possibility of the Clinical use of Metoprolol in Patients with Bronchial Asthma
    Junzaburo Kabe, Yoshio Sakamoto, Sohei Makino, Takeshi Fukuda
    Article type: Article
    1981 Volume 30 Issue 1 Pages 33-44
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.33
    JOURNAL FREE ACCESS
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    The present study was designed to confirm whether or not the concurrent administration of terbutaline and metoprolol, a new cardio (β_1)-selective blocking agent, might (1) increase the respiratory tract hypersensivity of asthma patients, and (2) give rise to deterioration of pulmonary function in these patients. The results obtained in this study were as follows. 1) In comparison with the respiratory tract hypersensivity for the patients with bronchial asthma when any drugs were not given, the sensitivity increased when terbutaline and propranolol were given concurrently. When terbutaline and metoprolol were given, it did not increase in any patients. 2) After 11 patients with bronchial asthma first received terbutaline alone for 7 days and then terbutaline and metoprolol concurrently for 7 days, the patients were monitored for changes in pulmonary function. An increase was observed in FEV_1.0 and VC in both of these two conditions, and no significant difference was observed between them. However, in one of three severely ill patients, both FEV_1.0 and VC were suppressed by metoprolol. 3) A significatly greater decrease in both pulse rate and blood pressure was observed after the concurrent administration of terbutaline and metoprolol than after the administration of terbutaline alone. 4) The number of asthmatic and wheezing episodes did not increase during the term of concurrent metoprolol administration, as compared with the period during which terbutaline alone was administered.
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  • THE EFFECTS OF IMMUNOTHERAPY ON HUMORAL AND CELLULAR RESPONSES IN PATIENTS WITH HOUSE DUST SENSITIVE ASTHMA
    Shiko Furukawa, Masao Negishi, Terumi Takahashi
    Article type: Article
    1981 Volume 30 Issue 1 Pages 45-51
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.45
    JOURNAL FREE ACCESS
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    In order to investigate the mechanism of specific immunotherapy, in vitro lymphocyte proliferative responses to house dust (HD) antigen, house dust mite antigen and PHA-P were examined in 61 patients with bronchial asthma. Further, allergic antibodies, such as specific IgE and total IgE in the patients'sera were measured using RAST and RIST. The results were as follows; 1) There was a good correlation between the proliferative responses of cultured lymphocytes from asthmatic patients to HD and HD mite antigen (γ=0.8036, p<0.01), suggesting that the mine contained in HD would be a major allergenic component. This HD stimulated lymphocyte responses were specific, since lymphocyte reactivity to PHA-P showed the same level responses with that of normal subjects. 2) HD sensitive patients showed statistically higher lymphocyte stimulation index (SI) than normal control subjects. 3) Along the time course of immunotherapy, SI tended to show gradually lower values. 4) The lymphocyte proliferative responses to HD antigen were proved significantly low in values. ents with excellent improvement compared with the patients who showed no improvement. From the above results, the reduction of lymphocyte response through immunotherapy seems to be associated with a good clinical improvement. Furthermore, it is indicated that the measurement of SI would help to evaluate the effect of immunotherapy.
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  • [title in Japanese]
    Article type: Appendix
    1981 Volume 30 Issue 1 Pages 53-
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.53
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1981 Volume 30 Issue 1 Pages 54-
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.54
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1981 Volume 30 Issue 1 Pages 55-58
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.55
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1981 Volume 30 Issue 1 Pages Cover3-
    Published: January 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Cover3
    JOURNAL FREE ACCESS
    Download PDF (260K)
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