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Volume 30, Issue 11
Displaying 1-16 of 16 articles from this issue
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Article type: Cover
1981 Volume 30 Issue 11 Pages Cover7-
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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Article type: Cover
1981 Volume 30 Issue 11 Pages Cover8-
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (45K) -
Article type: Bibliography
1981 Volume 30 Issue 11 Pages Misc3-
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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Zoltan OvaryArticle type: Article
1981 Volume 30 Issue 11 Pages 1005-1014
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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Klaus EichmannArticle type: Article
1981 Volume 30 Issue 11 Pages 1015-1023
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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Kazunori Hirokawa, Junichi YataArticle type: Article
1981 Volume 30 Issue 11 Pages 1024-1031
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSeveral problems involved in Ig production from various human T-and nonT-cell combinations stimulated with pokeweed mitogen were studied. 1) Ig production was markedly suppressed when T-cells were added to nonT-cells in excess of the optimal proportion. This suppression of Ig production seemed to be caused by the Mitomyscin C (MMC)-sensitive IgG-Fc receptor negative T-cells. 2) The allogeneic combinations of T-and nonT-cells sometimes produced little Ig as compared with autologous combinations. Most of such allogeneic restriction in helper function was resolved by treating T-cells with MMC. 3) Among T-and nonT-cells combinations which showed allogeneic restriction, there were combinations such that T-cells did not help allogeneic B-cells but in which B-cells could be helped by T-cells from the partner. The restriction usually occurred only in particular combinations. However, there were some exceptional cases as follows. B-cells from a certain individual could not be helped by most of the allogeneic T-cells from several partners, while T-cells from some other individuals did not help allogeneic B-cells from most of the partners. 4) The following method is tentatively recommended from the above observations. (1) To select the B-cells which are helped by T-cells from various allogeneic partners. (2) To use MMC-treated T-cells when native T-cells do not show helper effect. (3) To make it sure that the result of autologous combination is concordant with allogeneic combination.View full abstractDownload PDF (963K) -
Yasuo Arai, Keijiro Nitta, Takao Shida, Hiromasa ShiodaArticle type: Article
1981 Volume 30 Issue 11 Pages 1032-1041
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAnti-asthmatic effects and drug tolerance of selective β_2-adrenergic stimulants were studied in experimental conditions. 1. The reproducibility of bronchoconstriction was satisfastory in guinea-pigs sensitized by ovalbumin when experimental asthma was provoked by inhalation five times within a time span of 40 hrs. 2. Subcutateous injection of salbutamol 4000μg/kg, terbutaline 1000μg/kg or fenoterol 1000μg/kg inhibited the experimental asthma by about 80% (Impedane was measured before and 15 min after ovalbumin exposure). 3. The inhibitory effect on experimental asthma was reduced after repeated subcutaneous injections (10times) of salbutamol, terbutaline or fenoterol at the equivalent effective doses at 30 min intervals. 4. The reduction of the inhibitory effect was most remarkable in the case of terbutaline, followed by salbutamol. The use of fenoterol showed only a slight reduction. 5. The reduction of the inhibitory effect on bronchial constriction caused by repeated administration was recovered after 18 hrs interval.View full abstractDownload PDF (1137K) -
Motohiro Kurosawa, Toshikazu Nemoto, Tetsuji Tanaka, Ryuzo Fueki, Sets ...Article type: Article
1981 Volume 30 Issue 11 Pages 1042-1051
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA 15-year-old female was diagnosed as an allergic bronchopulmonaty aspergillosis based on Patterson's criteria for the disease, namely episodic bronchial obstruction, peripheral blood eosinophilia, immediate skin reactivity to Aspergillus antigen, precipitating antibodies against Aspergillus antigen, elevated serum IgE concentrations, history of pulmonary infiltrates, central bronchiectasis and so on. The patient was the eldest daughter of a brewer and it was assumed that she was exposed to a greater number of Aspergillus spores than would be usual under normal conditions. She had had episodic wheezing and pulmonary infiltrates at almost the same seasons in the past three years and it was suggested that this was due to high exposure of Aspergillus spores during that time. But from the results of the investigation of her family history, the present researchers believe that atopic host susceptibility will be more important in the pathogenesis of this disease than such enviromental factors. There were good correlations between the clinical findings on the patient and total IgE level, the specific IgE and IgG antibodies against. Aspergillus antigen. But total IgG and IgA levels were lower than normal during the course of this study. The patient was successfully treated with 5-fluorocytosine without the administration of glucocorticoid.View full abstractDownload PDF (1901K) -
Keiko HoshiArticle type: Article
1981 Volume 30 Issue 11 Pages 1052-1059
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe have developed an ELISA based on a solid phase sandwich method for measuring total serum IgE levels and specific IgE antibodies. Polystyrene beads coated with anti-human IgE rabbit γ-globulin and the anti-IgE γ-globulin labelled with peroxidase were used. For the measurement of specific IgE antibodies, either the beads coated with mite allergens or paper discs of RAST kit (Pharmacia) were used. The minimum and maximum concentration of IgE measurable by this ELISA were 25 and 1600 units/ml, respectively. Concentration of IgE measured by the ELISA gave a linear correlation coefficient of 0.99 with that determined by a conventional radioimmunoassay (RIST, Pharmacia). The levels of specigfic IgE antibodies measured by the ELISA using either beads or paper discs were well correlated with those by RAST. The procedure of ELISA was simpler and safer than that of RIA. Their results suggest that our ELISA is more useful than RIA for measuring total and specific IgE in the basic as well as clinical studies.View full abstractDownload PDF (947K) -
Kiminobu Minagawa, Takateru OkadaArticle type: Article
1981 Volume 30 Issue 11 Pages 1060-1070
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBasophil suspensions partially enriched from whole blood from allergic patients by gravity sedimentation with dextrose-dextran and allergen or anti-IgE-containing buffers were separately pre-equilibrated at 37℃ and then mixed together in equivolume ratios. In the experiments of suboptimal desensitization, the suboptimal concentrations of allergen or anti-IgE were fractionally added in five equal aliquots every 15 minutes and after an additional two hours of preincubation the cells were challenged with optimal concentrations of allergen or anti-IgE. For the purpose of induction of subthreshold desensitization, the anti-IgE was fractionally added in twelve equal aliquots every 30 minutes and the cells were allowed to preincubate for an additional two hours after the final addition of anti-IgE before challenge. Desensitized cells remained completely unresponsive to challenge with optimal concentrations of allergen or anti-IgE for at least 30 hours. The specificity of cell desensitization was non-specific in the case of donors involved in this study. The possibility is considered that very slight in vivo cell-desensitization occurs naturally on exposure to allergens in our environment.View full abstractDownload PDF (1489K) -
Shigeko Inokuma, Satoshi Sasaki, Toshiro Shibuya, Kunioki ArakiArticle type: Article
1981 Volume 30 Issue 11 Pages 1071-1076
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA case with tropical eosinophilia was reported; the cause was suspected to be an infection of Dirofilaria immitis (D.i.). The case was a 31 year-old male student studying anthropology. He had stayed in Malaysia for approximately one year beginning in August, 1978, living with the natives in a jungle, where there were many dogs and mosquitoes. The patient had begun to suffer from cough with stridor and dyspnea before dawn, begining in February, 1979. Even after he returned to Japan in August of 1979, the patient's symptoms had continued, and he visited our clinic in April, 1980. Several inguinal lymphnodes were palpated bilaterally. Peripheral blood eosinophile count was 3655/mm^3, IgE was 7850ng/ml, precipitation test in agarose gel was positive against antigens from D.i., Toxocara canis and Asaris suum, complement fixation test, ELISA and RAST count against D.i. antigen were >1:160 (control<1:10), >1:1280 (control<1:40) and 331.5 (control 33.9), respectively. No abnormality was seen in chest X-ray film. The attacks of wheezing and dyspnea were controlled satisfactorily by β_2-stimulant. Within several days after the administration of diethylcarbamazine citrate in June, the patient recovered completely without β_2-stimulant. Eosinophile count decreased to 700, and antibody titer for complement fixation test decreased to 1:80 in December, 1980.View full abstractDownload PDF (1134K) -
Toshiyuki Aoki, Masuko Fujita, Higashi Kushimoto, Tamio HorikoArticle type: Article
1981 Volume 30 Issue 11 Pages 1077-1083
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTwenty patients with actute urticaria of less than 2 weeks' duration were carefully questioned as whether any particular events had occurred before the urticaria had appeared. These patients were followed up for 3 months. Sixteen patients had experienced some of the following symptoms: a cough, sneezing, sore throat, headache, malaise, fever, chill, nausea, stomachache and diarrhea, mostly of short duration. The onset of these symptoms was noted in the period between 14 days before and 6 days after the appearance of urticaria. Only 4 patients had taking medicine when the urticaria appeared and 2 patients thought that food they had eaten might be the cause of the urticaria, but 5 of these patients had also experienced some of abovementioned symptoms. There were 2 patients who had not noticed any particular events associated with the onset of urticaria. All patients were given antihistamines but 3 did not take them. In 9 patients out of the 20, the urticaria cleared within 4 days after onset, in 6 between 6-9 days, and in 4 between 11-39 days, but in 1 patient the disease persisted for longer than 3 months. These results seem to suggest that the main cause of acute urticaria is infections, of which acute upper respiratory disease is the most common, and that in most cases the urticaria claers in a relatively short period.View full abstractDownload PDF (967K) -
Article type: Appendix
1981 Volume 30 Issue 11 Pages 1085-1092
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1981 Volume 30 Issue 11 Pages 1093-1094
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1981 Volume 30 Issue 11 Pages 1095-1098
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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Article type: Cover
1981 Volume 30 Issue 11 Pages Cover9-
Published: November 30, 1981
Released on J-STAGE: February 10, 2017
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