Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 30, Issue 4
Displaying 1-11 of 11 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1981 Volume 30 Issue 4 Pages Cover18-
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Cover18
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1981 Volume 30 Issue 4 Pages Cover19-
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Cover19
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1981 Volume 30 Issue 4 Pages Misc7-
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Misc7
    JOURNAL FREE ACCESS
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  • INHIBITING EFFECT ON PCA REACTION DUE TO BSA CAUSED BY ALLERGIC REACTIONS BY THE COMMON ANTIGENIC FACTOR BETWEEN MYCOBACTERIUM AND CORYNEBACTERIUM
    Yoshinobu Yamamoto
    Article type: Article
    1981 Volume 30 Issue 4 Pages 177-182
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.177
    JOURNAL FREE ACCESS
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    It has previously been reported that the interference phenomenon between two different antigen-antibody reactions in vivo occurring simultaneously was observed and also that the common antigenic factor between M. tuberculosis(AOYAMA-B) and C. equi(Ko-85) was elucidated serologically both in vitro and in vivo. In the present report, the interference between the allergic reactions caused by two different antigen-antibody systems was studied in guinea pigs sensitized with cells of M. tuberculosis(AOYAMA-B). Certain allergic reactions of the Arthus type elicited by a common antigenic factor between M. tuberculosis(AOYAMA-B) and C. equi(Ko-85) inhibited the passive cutaneous anaphylaxis(PCA) induced by bovine serum albumin(BSA) and anti-BSA rabbit serum. The PCA reaction caused by BSA system on animals sensitized with M. tuberculosis was also inhibited by simultaneous intravenous challenge of BSA and the CP fraction as evidenced by definite reduction of PCA titer due to BSA antigen-antibody system.
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  • IMMUNOLOGICAL STUDY OF IgA DEFICIENCY DURING ANTICONVULSALT THERAPY IN EPILEPTIC PATIENTS : 1.Surface Markers of Peripheral Blood Lymphocytes and IgA Production by PWM-Stimulated Lymphocytes
    Hiroshi Matsuoka, Junichi Okada, Shinpei Torii, Michiko Matsuoka, Chiz ...
    Article type: Article
    1981 Volume 30 Issue 4 Pages 183-189
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.183
    JOURNAL FREE ACCESS
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    The nature of the IgA deficiency in epileptic patients during anticonvulsant therapy was investigated. First, circulating T and B cells were assessed by surface markers in 10 epileptic patients and in a patient with primary IgA deficiency. The number of surface IgA bearing cells was within normal range, which suggested that the defects were present on the terminal differentiation of B cells. Therefore, the capacity of differentiation into immunoglobulin(Ig) producing cells was studied by lymphocyte cultures with pokeweed mitogen(PWM) stimulation. Cytoplasmic Ig was stained by immunofluorescence technique and the release of Ig into the culture supernatant was determined by radioimmunoassay. The results indicated that there were two groups according to the defects observed. The first group, consisting of 2 epileptic patients, showed IgA synthesis in cytoplasma without any release of IgA into the supernatant. The second group, comprised of 8 epileptic patients and a primary IgA deficiency patient, was found to fail to synthesize IgA. Thus, the IgA deficiency in these patients is seem to be a heterogeneous disease caused by at least two different defects in the process of the terminal differentiation of B cells.
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  • THE CLINICAL EFFECT OF SUSTAINED-RELEASE THEOPHYLLINE(T_<HEO>-D_<UR>) FOR ASTHMATIC CHILDREN AND SERUM THEOPHYLLINE LEVEL
    Takuro Masaki, Hiroko Sekine, Toshikazu Nagakura, Yoji Iikura, Yusuke ...
    Article type: Article
    1981 Volume 30 Issue 4 Pages 190-196
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.190
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    The "Theo-Dur"(sustained-release theophylline) was given twice a day(12 mg/kg/day) for a week to 59 asthmatic children. A week later, the theophylline concentration in the blood was in the range from 5 to 17 μg/ml. In these levels of theophylline concentration, the asthmatic symptoms were alleviated in 80% of severe cases, in 84% of moderate cases, and in 90% of mild cases, respectively. Pulmonary function(FVC, FEV_<1.0>, PFR) was improved significantly a week after treatment. The safety range of the theophylline concentration should be aimed at 15 μg/ml or less. If one is set the "steady state" at more than 15 μg/ml, it is necessary to monitor the levels of theophylline concentration. The application of Theo-Dur for the prevention of asthma attack(around the clock treatment) which was given twice a day(12 mg/kg/day) for 24 hours was successful in maintaining 5 μg/ml or higher levels of theophylline concentration and proved a satisfactory clinical improvement.
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  • METHACHOLINE HYPERREACTIVITY AND DSCG TREATMENT
    Yoshiro Kano
    Article type: Article
    1981 Volume 30 Issue 4 Pages 197-205
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.197
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    Methacholine inhalation tests, serum level of IgE, eosinophilic counts and skin tests were studied in asthmatic children to know the efficacy of DSCG treatment. 1)Among 21 DSCG treated children with asthma, whose methacholine reactivity were measured sequentially for one year, significant fluctuations were noted and the methacholine reactivity was closely correlated with changing severity of asthma before DSCG treatment. Methacholine reactivity was significantly improved after one year of DSCG treatment, but serum level of IgE, eosinophilic counts and skin tests were not significantly changed. 2)Improved cases could tolerate higher concentrations of methacholine than noneffective cases in 68 asthmatic children who were treated with DSCG for long term, and there was greater tendency of decreased methacholine reactivity in cases with a longer duration without attack. 3)There were no differences between DSCG effective group and non-effective one in terms of IgE levels, eosinophilic counts and skin tests.
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  • IgG_4 AND IMMEDIATE HYPERSENSITIVITY : Presence of IgG_4 in Human Basophil Granulocytes
    Takemasa Nakagawa
    Article type: Article
    1981 Volume 30 Issue 4 Pages 206-212
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.206
    JOURNAL FREE ACCESS
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    Quantification of human basophil degranulation induced by anti-IgE, anti-IgG_4, and by the relevant allergens, was performed in hay fever and bee venom-allergic subjects, using a flow-cytometric system. It was shown that not only anti-IgE and the allergens but also anti-IgG_4 can degranulate basophils in a dose-dependent manner, indicating the presence of IgG_4 in human basophil granulocytes. It was also shown that IgG_4 myeloma proteins as well as a serum containing high IgG_4 antibodies can passively sensitize basophils. In addition, it was shown that reagin-mediated basophil degranulation can be inhibited by passive sensitization with specific IgG_4 antibodies in bee venom hypersensitivity, suggesting that IgG_4 may act as blocking antibodies in such cases.
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  • CLINICAL EVALUTION OF RADIOALLERGOSORBENT TEST IN DIAGNOSIS OF POLLINOSIS
    Yoshinori Wagatsuma, Kaname Togashi, Chie Tobise, Shuzo Matsumoto, Aik ...
    Article type: Article
    1981 Volume 30 Issue 4 Pages 213-221
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.213
    JOURNAL FREE ACCESS
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    The clinical usefulness of radioallergosorbent test(RAST) in diagnosis of pollinosis was evaluated in 149 patients with pollinosis, pollinosis with bronchial asthma and bronchial asthma. The procedure was simple and reliable, and the results were summarized as follows:It is concluded that RAST is a useful and practical diagnostic test of pollinosis. In this experience, the positive reaction was determined by scoring 2 or more of RAST. In intradermal tests, the positive responses to pollen extracts were considered to be significant by using 1:10000 w/v or more of extract-concentration. 1. The agreeable positive results were obtained in either procedures from RAST and intradermal tests, which were 60% of three pollens(birch and oak) and 74.7% of grass pollens(orchard grass and timothy). However, these were rather low with ragweed and wormwood:54% and 47% respectively. 2. Although all of 31 allergens were positively reacted in the provocation tests, the positive reactions were obtained by RAST in 25 of 31 allergens(80.5%). 3. It has not been evaluated that the RAST score was related directly to the total IgE level in sera.
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  • [title in Japanese]
    Article type: Appendix
    1981 Volume 30 Issue 4 Pages 223-226
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.223
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1981 Volume 30 Issue 4 Pages Cover20-
    Published: April 30, 1981
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.30.Cover20
    JOURNAL FREE ACCESS
    Download PDF (774K)
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