All issues
Volume 31, Issue 1
Displaying 1-13 of 13 articles from this issue
- |<
- <
- 1
- >
- >|
-
Article type: Cover
1982 Volume 31 Issue 1 Pages Cover1-
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K) -
Article type: Cover
1982 Volume 31 Issue 1 Pages Cover2-
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (38K) -
Article type: Bibliography
1982 Volume 31 Issue 1 Pages Misc1-
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (356K) -
Sankei Nishma, Hayao Araki, Hiromi Kaizuka, Shunjiro KoizumiArticle type: Article
1982 Volume 31 Issue 1 Pages 1-8
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSInstead of a bicycle ergometer in the first study, a treadmill was used in this study to produce exercise-load of 6km/h, 10%, 6min. Seventy-one asthmatic and 26 healthy children were subjected to examine relation between their pre-load severity of asthma and the change of ventilatory function in EIB. The results were as follows: 1. No significant correlations were found between the grade of asthmatic symptoms in pre-exercise term and the severity of EIB, although, there has been a definite correlation using a bicycle erogometer. 2. The study suggested that the standard critical values by using a treadmill should be over 10% fall in FVC, over 15% fall in FEV_1, over 25% fall in PEFR, over 30% fall in V_<50>, over 35% fall in MMF, and over 45% fall in V_<25>. 3. Using a treadmill to make exercise -load, FEV_1 was the sensitive parameter of ventilatory function to detect positive EIB, and using the FEV_1 and V_<50> in combination to detect positive EIB, 91.5% of asthmatic cases were interpreted as positive among those who responded to exercise-load. 4. The severe the asthma, the more difficult it was for the child to keep the speed and load indicated on the treadmill. From the above results, now it is apparent that the bicycle ergometer method is more adequate for quantitative analysis of EIB in relation to the severity of pre-exercise asthmatic symptoms.View full abstractDownload PDF (933K) -
Susumu Sugai, Susumu Konda, Masaki Yamamoto, Masumi Nawate, Sadao Tsuk ...Article type: Article
1982 Volume 31 Issue 1 Pages 9-17
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA Japanese female with DNA autosensitivity, manifesting chronic bleeding skin ulcers and spontaneous painful ecchymoses of the extremities, nosebleed, hematemesis, rectal and uterine bleeding, hematuria, aphthae, and bronchial asthma is reported. Rejection of autologous skin grafts on the bleeding ulcers occurred on seven occasions over a 12-year period. Painful, tender erythematous swelling and ecchymoses identical with spontaneous ecchymoses were produced by intradermal injections of lysed autologous leukocytes and calf thymus DNA. In vitro incubation of either substance with DNase or chloroquine sulfate abolished these skin reactions. Passive cutaneous anaphylaxis (PCA) test using calf thymus DNA, prodcuced a hemorrhagic cutaneous reaction with blueing. Chloroquine sulfate therapy resulted in the complete suppression of bleeding from all different sites and of the asthma attacks.View full abstractDownload PDF (1410K) -
Hiroshi Yasueda, Yasuo Yui, Haruhisa Mita, Takaharu Shimizu, Takao Shi ...Article type: Article
1982 Volume 31 Issue 1 Pages 18-28
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA solid phase radioimmunoassay using radiolabeled protein A from staphylococcus aureus has been developed to measure IgG antibody to sugi basic protein (SBP) in sera of sugi sensitive patients. The backgroud counts due to non-specific adsorption of serum IgG on solid phase were minimized by the use of glass rod as solid phase. The values of anti SBP content of 25 human sera obtained with this assay correlated highly (r=0.980, p<0.001) with those obtained with double antibody radioimmunoassay using radiolabeled SBP. This assay could be applied to IgG quantitation for crude allergen extracts as well as purified antigens. The procedure of this assay, using glass rod as solid phase, is as simple as using paper disc as solid phase in RAST. These results indicate that ^<125>I-protein A solid phase radioimmunoassay using glass rod as solid phase may be applicable for measurement of IgG antibodies to many kinds of antigens which are clinically important.View full abstractDownload PDF (1339K) -
Hidenori FujiwaraArticle type: Article
1982 Volume 31 Issue 1 Pages 29-37
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRecently it was reported that chemical mediators such as histamine or bradykinin in the IgE-mediated allergic reactions not only inhibit the release of histamine from target cells, but also inhibit the delayed type allergic reaction or cell-mediated immune response. The effects of chemical mediators such as histamine, brdykinin, serotonin or acetylcholine on antigen or mitogens (Con A, PHA, LPS)-induced lymphocyte proliferation in the IgE mediated allergic reaction were studied. The results obtained were as follows: 1) Antigen-induced lymphocyte proliferation was inhibited by treatment with histamine (10^<-4>-10^<-5>M) or bradykinin (10^<-5>M). But it was also significantly inhibited by treatment with serotonin or acetylcholine. 2) Lymphocyte proliferation indeced by mitogen (Con A, PHA) was slightly inhibited by treatment with 10^<-4>M serotonin, but no inhibitory effect was observed by treatment with acetylcholine. 3) Inhibitory effect of histamine or bradykinin against lymphocyte proliferation induced by antigen or mitogen (Con A) was not blocked by pretreatment with H_1-antagonist (chlorpheniramine), but fairly well blocked by pretreatment with H_2-antagonist(cimetidine). These results suggest that the inhibition of lymphocyte activation by histamine or bradykinin may mediated through a H_2 receptor on lymphocytes and that immediated hypersensitivity reactions may affect subsequent expression of cell-mediated immune reactions.View full abstractDownload PDF (1072K) -
Kotaro Ukai, Yasuo Sakakura, Yukiko Itoh, Fumi HamaguchiArticle type: Article
1982 Volume 31 Issue 1 Pages 38-45
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis study was undertaken to ascertain whether nasal mucosal hypersensitivity to histamine and acetylcholine in asthmatic patients could be differentiated from that in nasal allergic patients. Nasal mucosal hypersensitivity to histamine and acetylcholine was measuring in fifty-one petients between the ages of 4 and 16 years with extrinsic asthma (asthma group) and compared with measurements obtained in 54 patients of nasal allergy (nasal allegy group) and 11 control subjects. We observed the following: 1. There was no difference in nasal hypersensitivity to histamine and acetylcholine between children and sdults in the normal group or the nasal allergy group. 2. The threshold for nasal hypersensitivity to histamine and acetylcholine was significantly higher in the asthma group than in the nasal allergy group. 3. There was no significant correlation between forced expiratory volume in one second(FEV_1) and nasal mucosal hypersensitivity in the asthma group, but there was significant inverse correlatiion between these parameters in the mild asthma group with more than 70% FEV_1. It was concluded that the difference in nasal symptoms between the patients with asthma and those with nasal allergy might be explained by the difference in nasal mucosal hypersensitivity.View full abstractDownload PDF (954K) -
Takuzo Nagano, Keisuke KanaoArticle type: Article
1982 Volume 31 Issue 1 Pages 46-50
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA case is reported of a 27-year-old woman who exhibited eczematous lesions of both hands. Soon after she had had contact with raw prawn, she noticed a manifestation of urticaria at the very portions of contact with them. Examination demonstrated that contact urticaria was induced by an allergic reacrion of Coombs I type originating from proteins which thought to adhere to the outside of the prawn crust. In other words, the reagin was found by an epi-and intracutaneous test of raw prawn extract solution, and confirmed by the RAST test. Nevertheless, the antigen is so unstable that its antigenicity seems to undergo a change within a short time.View full abstractDownload PDF (640K) -
Shiro Kasuya, Hiroshi OhtomoArticle type: Article
1982 Volume 31 Issue 1 Pages 51-57
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPeritoneal eosinophilia was induced by repeated intra-peritoneal injections (once a week) of dinitrophenyl-coupled Ascaris suum antigen (DNP-Asc) into strain-13 guinea pigs. After more than 10 shots of antigen, almost constant counts of eosinophils were obtained from the peritoneal cavity following each stimulation of DNP-Asc. Peritoneal eosinophilia was also induced by the injection of DNP-heterologous carrier into DNP-Asc administered animals, so that this response is thought to be hapten-dependent. The influence of sensitized lymphocytes on hapten-dependent eosinophilia was studied. The results were as follows; (1) peritoneal eosinophilia was suppressed by complementary immunization with ovalbumin (OA) or bovine serum albumin emulsified into complete Freund's adjuvant (CFA). On the other hand, no suppression of eosinophilia was observed in complementary immunization with Asc. (2) Complementary immunization with OA emulsified into incomplete Freund's adjuvant did not affect the eosinophilia. (3) Peritoneal eosinophilia was suppressed with application of spleen cells that were collected from OA (with CFA)-immunized animals. (4) Delayed type skin reactions were positive in eosinophilia-suppressed animals. These data suggested that hapten-dependent peritoneal eosinophilia was suppressed by induction or transfer of sensitized lymphocytes in an antigen-non-specific manner.View full abstractDownload PDF (1004K) -
Shinji Motojima, Takeshi Fukuda, Sohei MakinoArticle type: Article
1982 Volume 31 Issue 1 Pages 58-64
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo investigate the mechanism of EIA, we compared the effects of inhibitor of IgE mediated chemical mediator release (azelastine) which also possesses H_1-blocking potency, and H_1-blocker (diphenhydramine). Maximum %fall in FEV_<1.0> of 13 asthmatic patients was 37.2±3.4% (mean±SE) after treadmill exercise. When patients were pretreated with azelastien or diphenhydramine, maximum %fall in FEV_<1.0> was 10.4±2.5% or 24.1±6.7%, respectively. The difference between these two values was statistically significant. %protection by azelastine or diphenhydramine was 64±8% or 40±11%, respectively. This difference between them was statistically significant. This difference was thought due to the fact that azelastine might possess inhibiting potency of chemical mediator release and diphenhydramine dose not. On the other hand, %protection by these two drugs showed significant correlation (r=0.81). This is explained by the fact that azelastine shares H_1-blocking potency with diphenhydramine, resulting in the reduction of EIA. Our observations are consistent with the hypothesis that histamine release is inbolved in the onset of EIA.View full abstractDownload PDF (780K) -
Article type: Appendix
1982 Volume 31 Issue 1 Pages 65-68
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (263K) -
Article type: Cover
1982 Volume 31 Issue 1 Pages Cover3-
Published: January 30, 1982
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (246K)
- |<
- <
- 1
- >
- >|