Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 31, Issue 3
Displaying 1-13 of 13 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 3 Pages Cover16-
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover16
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 3 Pages Cover17-
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover17
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1982 Volume 31 Issue 3 Pages Misc6-
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Misc6
    JOURNAL FREE ACCESS
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  • A STUDY ON THE CONTROL OF BLOOD LEVELS OF HISTAMINE BY INTRAVENOUS ADMINISTRATION OF STEROIDS AND SYNTHETIC ADTH IN PATIENTS WITH BRONCHIAL ASTHMA
    Mikio Matsui
    Article type: Article
    1982 Volume 31 Issue 3 Pages 141-150
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.141
    JOURNAL FREE ACCESS
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    An investigation was made of changes in histamine levels of whole blood and plasma, as well as in basophil and eosinophil counts, following intravenous administration of 4mg dexamethasone, 500mg hydrocortisone or 0.25mg synthetic ACTH in healthy subjects and in patients with bronchial asthma during asymptomatic period. Blood levels of histamine were determined by the assay method of Shore as modified by Komatsu, basophil and eosinophil counts were obtained by the simultaneous counting method of Kimura. The histamine levels of whole blood and plasma and basophil and eosinophil counts all decreased to their maximum extent in 6 to 12 hours after the intravenous administration of 4mg dexamethasone or 500mg hydrocortisone. Following a 0.25mg intravenous dose of synthetic ACTH, plasma histamine only was diminished in 1 to 6 hours. Decrements of these 4 parameters were greatest with dexamethasone, followed by hydrocortisone and synthetic ACTH in that descending order of effectiveness. The study thus demonstrated that intravenous administration of steroids and synthetic ACTH were effective in control of blood histamine levels, basophil and eosinophil counts in asthmatic patients.
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  • EXPERIMENTAL STUDY OF SPECIFIC HYPOSENSITIZATION
    Masahito Inazawa, Tohru Nagasawa, Tsugio nakazawa
    Article type: Article
    1982 Volume 31 Issue 3 Pages 151-156
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.151
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    An IgE and IgG antibody producing system was made in BALB/c mice using Maiko antigen, the allergen of Konjac bronchial asthma, with alum. Four weeks after injection of allergen, the mice began to produce reaginic antibody to the allergen and they continued to produce it for at least 4 months. On the other hand, IgG antibody levels subsided gradually and dropped to half within a month. In order to clarify the mechanism of specific hyposensitization serial antigen injections were done on this "on going" IgE and IgG producing system. IgE antibody levels did not subside, but, on the contrary, seemed to go up as a result of these injections. As for IgG antibody, the longer the mice received the antigen and the more of it they received, the more IgG antibody they produced. It seems that this experimental system may contribute to clarification of the mechanism of specific hyposensitization therapy.
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  • STUDIES ON CONCANAVALIN A-INDUCED SUPPRESSOR CELL FUNCTION AND SOLUBLE IMMUNE SUPPRESSOR SUPERNATANT FROM CONCANAVALIN A-INDUCED SUPPRESSOR CELLS IN HEALTHY DONORS AND PATINETS WITH CHRONIC ACTIVE RHEUMATOID ARTHRITIS
    Kazuo Kobayashi
    Article type: Article
    1982 Volume 31 Issue 3 Pages 157-165
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.157
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    Concanavalin A (Con A) -induced suppressor cell function and soluble immune suppressor supernatant (SISS) elaborated from Con A-activated suppressor cells were examined, using peripheral blood mononuclear cells (PBMC) from five healthy individuals and 9 patients with chronic active rheumatoid arthritis (RA). The results were as follows: 1)Physicochemical properties of SISS from healthy donors included the following: a)It was heat stable at 56℃, 30 min; b)It was heat labile at 80℃, 30 min; and c)It was inactivated by trypsin treatment. These findings indicate that there is SISS activity in protein fraction. 2)Biological characteristics of SISS from normal subjects revealed that: a)SISS activity was mainly produced from T cell containing fraction, such as PBMC and T cell fractions; b)SISS was a mediator on T-T interaction; and c)Mitomycin C inhibited SISS production at inducing phase of Con A-stimulated suppressor, but betamethasone suppressed SISS elaboration both at before and after generating stage. 3)In patients with chronic active RA, the following abnormalities were observed: a)Con A-activated T cell exhibited sufficient suppressor cell function; b)SISS from Con A-activated T cell had slight suppressor activity to autologous PBMC proliferative response; but c)Con A-induced non-T cell function had no suppressor cell activity and SISS activity to autologous cells. Loss of suppressor activity in Con A-preincubated non-T cell was not caused by impaired production of suppressor factor but by decreased sensitivity of RA-responder cells to SISS. These results indicate that there are suppressor cell dysfunction, impaired production of SISS from T cell fraction and decreased responder cell sensitivity to suppressor signal in patients with chronic active RA.
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  • ON THE ROLE OF CELL-MEDIATED IMMUNITY IN EXPERIMENTAL NEPHRITIS OF MICE ARISING FROM STREPTOCOCCAL INFECTION
    Naoaki Hayama
    Article type: Article
    1982 Volume 31 Issue 3 Pages 166-174
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.166
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    Using female BALB/c mice, 8 weeks of age, and group A streptococcus, Type 3 (strain B 930/24/3), experimental studies were carried out. Mice were divided into two groups; to one of the groups, heat-killed bacteria (2×10^8/ml) were injected intravenously (i.v. group) and to the other one, living cells (2×10^8/ml) were inoculated subcutaneously (s.c. group). The protein components and C-polysaccharide extracted from streptococcal cell walls were used as antigens. The humoral antibody titers against these antigens were measured by passive hemagglutination technique, and the delayed-type hypersensitivity (DTH) of the sensitized mice was tested by foodpad reaction. The production of humoral antibody was found in the sera of the i.v. group, but DTH was not induced in mice of this group. In mice of the s.c. group, the DTH to streptococcal protein components was positive and the antibody titers against these antigens were of at low levels. However, pathological changes of kidney were not observed in either the i.v. or the s.c. group. The lymphocytes obtained from the s.c. group were transferred into the i.v. group, and then the fragments of ultrasonic distrupture of heat-killed bacteria (transfer group) were injected intravenously to the mice. On light microscopic findings on these mice, the glomerulus showed segmental hypercellularity with proliferation of mesangial matrix, and in electron microscopic findings, the glomerulus showed swelling of endothelium and proliferation of mesangial matrix. The lymphocytes treated with anti-thymocyte serum and complement were transferred into the i.v. group. However, the pathological changes in the glomerulus were not observed in these mice. These findings suggest that pathological changes in experimental nephritis of mice may be induced by interaction of humoral and cellular immunity.
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  • PROGNOSIS OF BRONCHIAL ASTHMA : A Follow up Study of University Freshmen with Asthmatic History
    Shoji Nagata, Yukihiro Ago, Hideki Teshima, Yoshiro Imada
    Article type: Article
    1982 Volume 31 Issue 3 Pages 175-180
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.175
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    Out of 8055 university freshmen in the period from 1972 to 1975, 45 asthmatics (asthmatic group) and 57 students who had become asymptomatic for more than three years despite histories of childhood asthma (remission group), were selected and underwent medical examinations. A follow up study was carried out 4 years later, and 80.4 percent of the subjects responded to the questionnaires. The results were as follows: 1)Out of 31 subjects in the asthmatic group, 11 had become free of attacks for 4 years till they graduated, whereas of the 51 students in the remission group, 7 had relapsed. The relapses occurred significantly less after in the cases whose asymptomatic periods had been more than 4 years before the medical examinations (p<0.01). 2)There were no significant differences between the subjects who had been free of attacks and those who had had attacks during the 4 years after the medical examinations, with regard to the family allergic dispositions, sensitivity on skin tests, serum IgE levels and anti-mite IgE antibody titers (RAST). 3)The incidence of subjects who had asthmatic symptoms during the 4 years after the medical examinations was significantly higher in the cases whose respiratory threshold to acetylcholine was lower than 2700 μg/ml than in the cases with higher threshold (p<0.01). These results suggest that long-term remission can occur not infrequently after puberty and that bronchial responsiveness is an important factor in terms of the prognosis of childhood asthma.
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  • REGULATION OF HUMAN IgE PRODUCTION IN VITRO : I. IgE Production by Peripheral Blood Lymphocytes and its B Cell Tolerance
    Itsuo Iwamoto, Yasushi Nawata, Takao Yanagisawa, Shoji Yoshida, Takaki ...
    Article type: Article
    1982 Volume 31 Issue 3 Pages 181-187
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.181
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    The mechanisms of IgE production in atopics were studied in vitro. Peripheral blood B cells of atopic patients spontaneously produced IgE protein and specific IgE antibody in vitro in the absence of antigen and T cell help. By in vitro 24 hr precultivation of these B cells with antigen, specific IgE antibody production was suppressed, indicating the induction of specific IgE B cell tolerance. No suppressor cell activity was detected in this antigen-induced IgE antibody unresponsiveness.
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  • CLINICAL STUDY ON AUTOIMMUNE DISEASES ASSOCIATED WITH PNEUMOCONIOSES
    Isamu Ebihara
    Article type: Article
    1982 Volume 31 Issue 3 Pages 189-199
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.189
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    Three of 76 patients with pneumoconiosis were found to be autoimmune diseases. The prevalence rate of autoimmune diseases in pneumoconiosis ranged up to about 4%. It seemed to be strikingly high. Then, to evaluate the relationship between pneumoconiosis and autoimmune disease, autoantibodies and serum immunoglobulin levels in 71 patients with various pneumoconiosis (typical silicosis, pyrite lung with atypical silicosis, asbestosis and other pn.) were examined. The results revealed that the prevalence rate of positive autoantibodies and increased polyclonal gammaglobulin levels (IgA and IgG) was significantly higher in pneumoconiotic patients than in patients with COLD. The appearance of immunological abnormalities in patients with pneumoconiosis seemed to be caused by adjuvant effect of inhaled dusts. These results suggest that dust inhalation itself may play an important role in the development of autoimmune diseases.
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  • [title in Japanese]
    Article type: Appendix
    1982 Volume 31 Issue 3 Pages 201-
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.201
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  • [title in Japanese]
    Article type: Appendix
    1982 Volume 31 Issue 3 Pages 203-206
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.203
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 3 Pages Cover18-
    Published: March 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover18
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